Metabolic risk factors of lung damage in coal miners caused by dust

Background: and aim Finding metabolic risk factors for the development of lung damage in coal miners is one of the research priorities, as long as it can improve understanding of the pathogenesis of the target organs damage development due to occupational dust. Considering that the burden of occupational diseases is significant, there remains a need for these professions, and as there is no etiological treatment, the relevance of such studies is undeniable. Methods: This research analyzed the intermediates of purine metabolism, RNA, DNA, OMP and acid soluble fractions in the blood plasma of coal miners, depending on the length of service in dusty conditions and the influence of all factors on combined outcomes (diseases). Results: The median levels of guanine, adenine, hypoxanthine, xanthine and uric acid have a common significant trend with a decrease in median values of underground experience up to 3 years and an increase in the group of 5 or more years’ experience. During the underground experience from 3 to 5 years, the activity of xanthine oxidase increased, catalyzing the oxidation of xanthine to uric acid and then decreased. Statistically significant changes depending on the length of service were found for ASF and RNA. Conclusions: According to logistic regression data, the underground experience of 7–10 years, RNA and xanthine had a statistically significant effect on the disease's development in coal miners. Longtime underground experience increases the chance of a coal miner developing a combined outcome by 8.6 times. The predictive capability of the presented model was 85.4%.