The role of insulin resistance in blood glucose level changes in rats after cardiopulmonary resuscitation

The role of insulin resistance in blood glucose level changes in rats after cardiopulmonary resuscitation | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 18 September 2025 V1 Latest version Share on The role of insulin resistance in blood glucose level changes in rats after cardiopulmonary resuscitation Authors : Enming Lu , Qi Zhuo , Youhua Zhang , and Qingming Lin [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.175817359.97535509/v1 114 views 60 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background: In-hospital hyperglycemia is common among patients after cardiac arrest (CA) and cardiopulmonary resuscitation (CPR). It is not clear whether insulin resistance exists in these patients. This article explores the changing patterns of blood glucose levels in rats after CA/CPR and the possible mechanisms of action. Methods: Ten SD rats were randomly divided into the SHAM operation group (SHAM group) and the experimental group (CA/CPR group) according to the random number table method, with 5 rats in each group. In the SHAM group, CA was not induced except for general surgeries, and intraperitoneal glucose tolerance tests were conducted after the operation. The experimental group induced CA in rats by asphyxiation. CPR was performed 6 minutes later, and intraperitoneal glucose tolerance test was conducted 10 minutes after the restoration of spontaneous circulation (ROSC). The blood glucose and serum insulin levels at fasting, 0.5 hours, 1 hour, 2 hours and 3 hours were measured respectively. And calculate the Matsuda indices of the two groups. Rat pancreatic tissues were taken for HE staining to observe the islet morphology and analyze the number of islet β cells. Results: Compared with the SHAM group, the fasting blood glucose in the CA/CPR group increased, and the post-glucose loading blood glucose significantly increased (all P < 0.05); Serum insulin significantly increased on an empty stomach and after glucose loading (all P < 0.05). The Matsuda index in the CA/CPR group decreased significantly (P < 0.05). The number and morphology of islet β cells in the SHAM group and the CA/CPR group showed no obvious abnormalities. Conclusion : Hyperglycemia exists in rats after CA/CPR, and insulin resistance plays an important role. Supplementary Material File (main document.doc) Download 12.53 MB Information & Authors Information Version history V1 Version 1 18 September 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Authors Affiliations Enming Lu Shengli Clinical Medical College of Fujian Medical University View all articles by this author Qi Zhuo Shengli Clinical Medical College of Fujian Medical University View all articles by this author Youhua Zhang Shengli Clinical Medical College of Fujian Medical University View all articles by this author Qingming Lin [email protected] Shengli Clinical Medical College of Fujian Medical University View all articles by this author Metrics & Citations Metrics Article Usage 114 views 60 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Enming Lu, Qi Zhuo, Youhua Zhang, et al. The role of insulin resistance in blood glucose level changes in rats after cardiopulmonary resuscitation. Authorea . 18 September 2025. DOI: https://doi.org/10.22541/au.175817359.97535509/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. 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