The relationship between prognosis and temporal muscle thickness in 102 patients with primary glioblastoma:real-world evidence

Temporal muscle thickness measured on 3D MRI has recently been linked to prognosis in glioblastoma patients and may serve as an independent prognostic indicator. This single-center study looked at temporal muscle thickness and prognosis in patients with primary glioblastoma. Overall survival was the major study outcome. For a retrospective analysis from 2010 to 2020, clinical data from 102 patients with glioblastoma at the Department of Oncology Radiotherapy of the First Affiliated Hospital of Dalian Medical University were gathered. Of these, 55 cases from 2016 to 2020 included glioblastoma molecular typing data, which were analyzed separately.TMT was measured using improved T1-weighted magnetic resonance imaging at the time of GBM diagnosis. The overall survival (OS) of the patients was calculated using the Kaplan-Meier technique, the differences between the groups were assessed using the log-rank test, and the clinical outcomes of the two groups were compared using the Cox proportional risk model and multifactorial analysis. In 102 patients, the median TMT was 6.775 mm (range 4.95–10.45). Patients were grouped according to median TMT, and those in the TMT > median group had a considerably longer median overall survival (23.0 months) than those in the TMT median group (P 0.001; Log-rank test). Data from 55 cases containing molecular staging of glioblastoma alone were analyzed, and the median overall survival of patients in the TMT > median group (17.5 months) was significantly increased compared with the median overall survival of patients in the ≤ median group (9 months) (P < 0.001; Log-rank test). We can concluded that TMT can serve as an independent predictor of survival prognosis in patients with primary GBM, as well as in the era of molecular typing.