Serum copeptin and zinc-α2-glycoprotein levels are novel biomarkers of tolvaptan treatment in decompensated cirrhotic patients with ascites.

Serum copeptin and zinc-α2-glycoprotein levels are novel biomarkers of tolvaptan treatment in decompensated cirrhotic patients with ascites. | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research article Serum copeptin and zinc-α2-glycoprotein levels are novel biomarkers of tolvaptan treatment in decompensated cirrhotic patients with ascites. Ryuta Shigefuku, Motoh Iwasa, Akiko Eguchi, Mina Tempaku, Yasuyuki Tamai, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-52252/v2 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 01 Nov, 2021 Read the published version in Internal Medicine → Version 2 posted You are reading this latest preprint version Show more versions Abstract Background: The efficacy of tolvaptan, an orally active vasopressin V2-receptor antagonist, has recently been reported in patients with massive ascites unresponsive to conventional diuretics. However, the effect of tolvaptan varies among patients. Recently, the prognostic role of tolvaptan response in decompensated liver cirrhosis (LC) has started to attract more attention. Our aim is to elucidate predictive factors using serum copeptin (vasopressin precursor), zinc-α2-glycoprotein (ZAG), cystatin C (renal biomarker), neutrophil gelatinase-associated lipocalin (NGAL) and liver-type fatty acid-binding protein (L-FABP) that portend a good response to tolvaptan in LC patients with ascites. Methods: We enrolled 113 LC patients and divided into tolvaptan treatment group and non-treatment group. Tolvaptan (3.75 or 7.5 mg/day) was administrated to 38 LC patients with ascites and a follow-up assessment occurred after a 7-day tolvaptan treatment regimen. Results: We revealed predictive ability for kidney and/or liver damage in serum copeptin, ZAG, cystatin C, NGAL and L-FABP levels in all patients. Post 7-day tolvaptan treatment, 19 patients lost more than 1.5 kg of their body weight (Responders), while 19 patients did not change their body weight significantly (Non-responders). Basal blood urea nitrogen (BUN) (p=0.0014), serum copeptin (p=0.0265) and serum ZAG levels (p=0.0142) were significantly higher in the Non-responders. BUN (odds ratio 7.43, p=0.0306), copeptin (odds ratio 9.12, p=0.0136) and ZAG (odds ratio 7.43, p=0.0306) were determined to be predictive factors of drug responsiveness using multivariate logistic regression analysis. Conclusion: Serum BUN, copeptin and ZAG levels predict patient response to tolvaptan even when measured prior to treatment. Gastroenterology & Hepatology copeptin zinc-α2-glycoprotein (ZAG) tolvaptan liver cirrhosis ascites Figures Figure 1 Figure 2 Background Arginine vasopressin (AVP) is a potent antidiuretic hormone in the human body. Despite the clinical relevance of AVP in maintaining fluid balance and vascular tone, measurement of the mature form of AVP is difficult due to small size (9 amino acids), short half-life, and its ability to bind platelets 1 . Copeptin, a 39-amino acid glycopeptide that comprises the C-terminal part of the AVP precursor, was found to be a stable and sensitive surrogate marker for AVP release 2 . Current reports have demonstrated that a high serum copeptin concentration predicts survival hospitalized liver cirrhosis (LC) patients, independent of liver-specific scoring systems 3 , suggesting that copeptin has the potential to be a biomarker of disease progression and prognosis in LC 4 . Zinc-alpha-2-glycoperotein (ZAG) is a 41-kDa glycoprotein synthesized by epithelial cells and adipocytes and plays a role in lipid metabolism, cell cycling and cancer progression. Serum ZAG levels has been reported as a biomarker of renal injury and can predict mortality in hemodialysis patients 5 . However, these changes in serum ZAG levels have not been reported in LC patients with ascites. There are several established markers of renal function, such as serum cystatin C, neutrophil gelatinase-associated lipocalin (NGAL), and liver-type fatty acid binding protein (L-FABP). Urea NGAL is established as a clinical biomarker for acute renal injury 6 based on NGAL function of a kidney protector 7 . Urine L-FABP levels derived from proximal tubular epithelial cells are elevated in renal tubular injury episodes and are therefore used as an established marker of several kidney diseases, including acute kidney injury and chronic kidney diseases 8 . We have reported that serum NGAL and serum L-FABP levels are prognostic factors for survival in chronic liver diseases 9,10 . Ascites is the most frequent complication of LC and refractory ascites has a negative prognostic implication in the natural progression of LC. Tolvaptan is a novel, orally administered, selective vasopressin V 2 -receptor antagonist that downregulates the expression of aquaporin-2 in the renal collecting duct. Current research has uncovered a promising role for tolvaptan as an add-on treatment in patients with hepatic ascites resistant to furosemide and/or spironolactone, as it is able to decrease body weight and alleviate edema 11,12 . However, the effect of tolvaptan is highly variable among patients with approximately one half of the patient cohort responding to the drug 11 . Blood urea nitrogen (BUN) 11 and C-reactive protein (CRP) 12 are recognized for differentiating diagnoses between Responders and Non-responders for tolvaptan, but these factors are insufficient, thus additional biomarkers are needed. Recently, in addition to the aforementioned studies, several studies have also reported Responders to tolvaptan led to improvement of long-term survival rates in cirrhotic patients with ascites 13,14 . Therefore, the aim of this study is to assess the correlation between the efficacy of tolvaptan and treatment related factors, including serum copeptin, ZAG, cystatin C, NGAL and L-FABP levels in LC patients with ascites. Methods Human samples The study protocol was approved by the Clinical Research Ethics Review Committee of Mie University Hospital. This study was performed retrospectively on stored samples, and patients could opt out of their data. In this study, we enrolled 113 LC patients (69 males and 44 females) with a median age of 68.0 (60.0-75.0) years who could be analyzed between November 2013 and September 2016 at Mie University hospital. Patients positive for hepatitis B surface antigen were diagnosed HBV infection, whereas those positive for anti-hepatitis C virus (HCV) were diagnosed HCV infection. Alcoholic cirrhosis defined as the presence of alcohol consumption >60 g/day. Nonalcoholic steatohepatitis was diagnosed based on pathological findings or fatty liver without any other evident causes of chronic liver diseases (viral, autoimmune, genetic, etc.). We divided the 113 LC patients into three groups: without ascites group (n=46), with ascites non-treatment group (n=22) and with ascites treatment group (n=45) (Table 1). LC was diagnosed based on morphologic changes of the liver such as hypertrophy of the left lateral and caudate lobes, or atrophy of the right posterior hepatic lobe on ultrasonography and through blood tests, and/or computed tomography, magnetic resonance imaging, FibroScan (Echosens, French) results, and esophageal varix by endoscopy, as is the general protocol. FibroScan cannot be used in individuals with ascites, therefore, it was performed for assessing liver fibrosis mainly in chronic hepatitis or early cirrhosis. The definition of idiopathic portal hypertension/portal-sinusoidal vascular disorder was based on the absence of characteristic cirrhosis and known causes of liver disease. Decompensated cirrhosis was diagnosed as it presents with a series of clinical and laboratory signs, e.g. ascites, encephalopathy, gastrointestinal bleeding, thrombocytopenia or hypoalbuminemia. HCC was diagnosed based on histological findings or typical imaging characteristics. Body mass index (BMI) was calculated as weight (kg)/height (m) squared. BMI was not adjusted for ascites. We provided body composition analysis by measuring the psoas muscle index (PMI) due to the limitations of BMI in patients with ascites. Using cross-sectional CT at the level of transverse process of lumbar vertebra L3, the bilateral psoas muscle area was identified. PMI (cm 2 /m 2 ) was defined by normalizing psoas muscle area (cm 2 )/height (m) squared. Patients who had other malignancies within the past 3 years, spontaneous bacterial peritonitis, hepatic encephalopathy (coma scale score ≥ II), heart failure (the New York Heart Association defined category ≥class II), human immunodeficiency virus infection, pregnancy, or psychiatric problems were deemed to be unsuitable for clinical study. Algorithm for treatment of ascites and definition of responder and non-responder As a general rule, the follow-up examinations included routine physical examinations and biochemical tests and diagnostic imagining studies including ultrasonography. All treatments of ascites were performed following the Japanese practical guidelines for LC in 2015 as possible 15 . Patients with grade 1 mild ascites do not need diuretics and a low sodium diet. For patients with grade 2 moderate ascites, treatment begins with the administration of spironolactone at 25-50 mg /day, then, in the absence of an effect, furosemide is added at 20 mg/day. Tolvaptan was recommended adding on other diuretics including 25-50 mg/day spironolactone and/or 20-40 mg/day furosemide, especially in patients with sustained hyponatremia. We divided the patients into two tolvaptan treatment groups: Responders and Non-responders. The Non-responder group was defined as patients with weight loss of <1.5 kg/week after receiving tolvaptan or performing paracentesis within the first week 12 . All patients continued to take the same prescribed doses of furosemide and spironolactone within the first week 16 . Serum preparation In the without ascites group and with ascites non-treatment group, serum samples were collected when patients showed up at the hospital. In the with ascites treatment group, serum collection was immediately before the administration of tolvaptan. Albumin (g/dL), total bilirubin (mg/dL), sodium (mEq/L), creatinine (mg/dL), BUN (mg/dL), CRP (mg/dL), α-fetoprotein (AFP; ng/mL) and des-γ-carboxy prothrombin (DCP; mAU/mL) were measured. Serum were kept at -80℃ until copeptin (pmol/L), ZAG (μg/dL), cystatin C (mg/dL), NGAL (ng/mL) and L-FABP (ng/mL) measurements, using an automated copeptin immunofluorescent assay kit (Thermo Fisher Scientific Inc., Tokyo) 2 , ZAG enzyme-linked immunosorbent assay (ELISA) kit (BioVendor, Czech Republic), cystatin C ELISA kit (R&D systems, Minneapolis, MN), NGAL ELISA kit (R&D systems, Minneapolis, MN) and high-sensitivity human L-FABP ELISA kit (CMIC Holdings Co., Ltd., Tokyo), respectively. The Child-Pugh score, albumin-bilirubin (ALBI) score 17 , the fibrosis index based on 4 factors (FIB-4) 18 , model for end-stage liver disease (MELD) score, MELD-Na score and estimated glomerular filtration rate (eGFR) with Cockcroft and Modification of Diet in Renal Disease (MDRD) formula were calculated. Statistical analysis All data are expressed as median and range. Data were analyzed using the Mann-Whitney U test in two groups and one-way analysis of variance for comparison of continuous variables. The relationship between serum copeptin, ZAG, cystatin C, NGAL, L-FABP levels and clinical data were examined using Spearman’s rank correlation coefficient. For each continuous variable, the optimal cutoff value that maximized the sum of sensitivity and specificity was selected using receiver operating characteristic (ROC) analysis for survival. A logistic regression analysis was utilized for the multivariate analysis in order to evaluate the relationship between effect of tolvaptan and clinical data. Only variables deemed to be significant (p<0.1) in the univariate analysis were included in the subsequent multivariate analysis. The statistical analyses were performed using JMP software program (SAS Institute, Cary, NC, USA) for univariate and multivariate logistic regression analysis. Differences were considered to be significant at p<0.05. Results Clinical characteristics of patients with or without tolvaptan Cohort creation were summarized in the patient flow (supplementary Figure 1). In this study, we divided the 113 LC patients into 3 groups : without ascites group, with ascites non-treatment group or with ascites treatment group. Table 1 shows the comparison of baseline clinical characteristics and laboratory variables between non-treatment group and treatment group. In the treatment group, AST, total bilirubin, CRP, the Child-Pugh score, ALBI score and FIB4-index were significantly increased, while serum albumin and sodium levels were reduced, suggesting that patients treated with tolvaptan demonstrated more advanced liver diseases. In the treatment group, the dose of diuretics drugs (Furosemide and/or Spironolactone) was significantly higher. In contrast, there were no obvious differences in age, gender, bodyweight, BMI, PMI, prevalence of HCC, ALT, prothrombin time, MELD score, MELD-Na score, creatinine, BUN, eGFR (Cockcroft and MDRD-6), copeptin, ZAG, NGAL, L-FABP and cystatin C between the two groups (Table 1). Correlation of copeptin, ZAG, cystatin C, NGAL and L-FABP to clinical parameters in all patients The correlations between copeptin, ZAG, cystatin C, NGAL or L-FABP and clinical parameters in LC patients were shown in Table 2. Copeptin was strongly correlated with mainly hepatic function including albumin (p=0.0007; Figure 1-D), Child-Pugh score (p<0.0001), ALBI score (p=0.0003) and CRP (p=0.0047; Figure 1-C). In contrast, ZAG was more strongly correlated with renal function including creatinine (p<0.0001), BUN (p<0.0001) and GFR (MDRD-6) (p<0.0001) (Table 2; Figure 1-K and L). In addition, ZAG was correlated with bodyweight (p=0.0092; Figure 1-G), BMI (p=0.0001; Figure 1-H) and CRP (p<0.0001; Figure 1-I). Cystatin C was significantly correlated with age (p=0.0191), renal parameters (creatinine, BUN and eGFR: p<0.0001), copeptin (p=0.0008), NGAL (p<0.0001) and L-FABP (p<0.0001) (Table 2). NGAL and L-FABP were significantly correlated with indicators of both renal function and hepatic function (Table 2). MELD-Na score significantly correlated with all, copeptin (p=0.0008), ZAG (p=0.001), cystatin C (p<0.0001), NGAL (p<0.0001) and L-FABP (p=0.0003). Background comparison between Responders and Non-responders to tolvaptan In this study, we excluded 7 from 45 cases for which tolvaptan efficacy could not be determined because of transferring hospitals, lack of weight data or with other treatment such as albumin transfusion, large volume paracentesis, and cell-free and concentrated ascites reinfusion therapy (Supplementary Figure 1). We enrolled 38 decompensated LC patients with ascites (24 males and 14 females) with a median age of 66.0 (59.5-73.0) years. We divided the 38 patients into two tolvaptan treatment groups: Responders and Non-responders. There were no obvious differences in age, gender, bodyweight, BMI, PMI, presence of HCC, AFP, DCP, dose of diuretic drugs, albumin, total bilirubin, Child-Pugh score, ALBI score, FIB4-index, MELD score/MELD-Na score, creatinine, eGFR, serum sodium, cystatin C, NGAL and L-FABP between the two groups (Table 3; Figure 2-D, E and F). In contrast, BUN, copeptin and ZAG levels were significantly higher in Non-responders when compared to the Responders group (respectively, p=0.0014, p=0.0265, p=0.0142) (Table 3; Figure 2-A, B and C). We further examined except for HCC, because HCC have pro-inflammatory condition. BUN (p=0.015) was significantly higher in Non-responders (n=7) when compared to the Responders (n=8) in patients without HCC. In contrast, copeptin and ZAG levels were not higher in Non-responders in patients without HCC. Predictors contributing to the effect of tolvaptan in treatment for ascites We calculated the cutoff values, area under the ROC curve, sensitivity and specificity of BUN, copeptin and ZAG using ROC analysis. The cutoff values ascertained from our analyses of BUN, copeptin and ZAG were 18.3mg/dL, 10.1pmol/L and 32.4 μg/mL, respectively (Table 4). The contribution of HCC, BUN, copeptin and ZAG were evaluated using multivariate logistic regression analysis. We found serum BUN (odds ratio 7.43, p=0.0306), copeptin (odds ratio 9.12, p=0.0136) and ZAG (odds ratio 7.43, p=0.0306) levels to be the significant predictors contributing to the efficacy of tolvaptan in the treatment for ascites; however, presence of HCC was not selected (Table 4). Discussion In this study, we revealed for the first time that serum copeptin and ZAG levels were significantly increased in the tolvaptan treatment Non-responders group when compared to the Responders group. In addition, we indicated that serum BUN, copeptin and ZAG levels were independent predictors of the overall response to tolvaptan therapy. We further showed that serum creatinine and cystatin C levels were not predictive of patient response to tolvaptan, thus confirming the findings reported by others 11,12 . In LC, arteriolar vasodilation causes underfilling of the systemic arterial vascular space, and the decrease in the effective blood volume leads to a decrease in arterial pressure 19 . Consequently, activation of the renin-angiotensin-aldosterone system, sympathetic nervous system and the release of antidiuretic hormone take place as the body attempts to restore normal blood pressure homeostasis 20 . The main physiological function of AVP is antidiuresis, thereby regulating systemic osmotic pressure. Plasma AVP levels are normally regulated by plasma osmotic pressure and have been found to be elevated in LC patients with ascites, as reported by Pérez-Ayuso RM 21 . However, there has been no study to date exploring whether the effect of tolvaptan is related to plasma AVP or pro-AVP (copeptin) levels in ascites patients. The Non-responder group is considered to be in a state of relative vascular underfilling with an increase in BUN and copeptin, thus suggesting intravascular dehydration 11 . Furthermore, serum copeptin also correlated with multiple factors including renal function and CRP, resulting in copeptin was not only a biomarker of renal function. Although NGAL and L-FABP are useful markers than copeptin for acute-on-chronic liver failure 22 and acute kidney injury 23 , respectively, this study indicated that serum NGAL and L-FABP were not useful in assessing the efficacy of response to tolvaptan in LC patients with ascites. Serum ZAG, it has been determined, is increased in acute kidney injury 24 and in minor kidney injury caused by normo-albuminuric diabetic kidney disease – patients presenting with renal insufficiency, but no significant proteinuria 25 . On the other hand, serum cystatin C accurately reflects renal function, while ZAG reflects lipolysis and renal function. Serum ZAG has been expected as a biomarker for cachexia 26 . Indeed, in this study, ZAG correlated with body weight, BMI and CRP. Bellos also reported that body weight loss and elevated CRP were the predictors for Non-responders to tolvaptan 12 . We assumed that association of serum ZAG with multiple factors including renal function, cachexia (relating to body weight and BMI) and/or inflammation (relating to CRP) led to the result. Based on the evidence outlined above, serum copeptin may reveal the underlying pathological condition of decreased osmotic pressure, intravascular dehydration and inflammation, whereas serum ZAG may reflect minor kidney injury, cachexia and inflammation, suggesting that copeptin and ZAG are independent predictors of patient response to tolvaptan. Although many patients with LC are complicated by HCC, it is not known whether coexistent HCC linked to response to tolvaptan therapy. Recent large-scale post-marketing surveillance study (n=1111) reported that there was no difference in mean of weight reduction by tolvaptan treatment between patients with and without HCC (p=0.2248) 27 . Both the American and European clinical practice guidelines recommended high-dose diuretic treatment against massive ascites 15 . In contrast, the Japanese guideline recommended additional tolvaptan administration for massive ascites. Together, clinical trials involving a large number of patients are needed to determine the timing of tolvaptan initiation. This study has several limitations. This was a retrospective and single-center study with a small sample size and a short follow-up period. Therefore, the confidence intervals of the predictors for tolvaptan treatment of ascites were huge due to a small sample size. Further study using a larger cohort, especially many cirrhotic patients without HCC, is required to investigate the interaction of copeptin, ZAG, and BUN and the possible predictors of patient survival. In conclusion, serum BUN < 18.3 mg/dL, copeptin < 10.1 pmol/L and ZAG < 32.4 μg/ml appear to be good predictors of overall patient response to tolvaptan treatment. Conclusions Serum copeptin, ZAG and BUN levels may be used as novel biomarkers to determine overall response to tolvaptan in patients presenting with LC and ascites. Future study is required to develop a new clinical prediction model using serum copeptin, ZGA and BUN that would help clinicians determine the effectiveness of tolvaptan treatment. Abbreviations LC, liver cirrhosis; ZAG, zinc-α2-glycoprotein; AVP, arginine vasopressin; NGAL, neutrophil gelatinase-associated lipocalin; L-FABP, liver-type fatty acid-binding protein; HCV, hepatitis C virus; BMI, Body mass index, PMI, Psoas muscle index; BUN, blood urea nitrogen; CRP, C-reactive protein; AFP, α-fetoprotein; DCP, des-γ-carboxy prothrombin; ALBI, albumin-bilirubin; FIB-4, fibrosis index based on 4 factors; MELD, Model for end-stage liver disease; eGFR, estimated glomerular filtration rate; MDRD, Modification of Diet in Renal Disease; ROC, receiver operating characteristic Declarations Statement of Ethics The study protocol was approved by the Clinical Research Ethics Review Committee of Mie University Hospital (approval no. H2019-190). This research comply with the guidelines for human studies and should include evidence that the research was conducted ethically in accordance with the World Medical Association Declaration of Helsinki. The subjects (or their parents or legal guardians) have given their written informed consent. Conflict of Interest Statement ( Competing interests ) Authors does not have any conflict of interests, except Motoh Iwasa received a lecture fee from Otsuka Pharmaceutical Co., Ltd, which manufactures tolvaptan. Consent to publish; All authors agree to publish. Availability of data and materials; Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine Funding Sources No external financial support was received. Author’s contributions RS: statistical analysis, data interpretation and drafting the article; MI: study concept, design, data acquisition, data interpretation and drafting the article; AE: sample analyses, data interpretation and critical revision of the article for important intellectual content; MT: sample analyses; YT: sample collection; TS: data analysis; YT: critical revision of the article for important intellectual content; All authors: approval of the final version of the manuscript Acknowledgement ; There was no acknowledgement. References Bolignano D, Cabassi A, Fiaccadori E, Ghigo E, Pasquali R, Peracino A, et al: Copeptin (CTproAVP), a new tool for understanding the role of vasopressin in pathophysiology. Clin Chem Lab Med. 2014;52(10):1447-1456. Morgenthaler NG, Struck J, Alonso C, Bergmann A: Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin. Clin Chem. 2006;52(1):112-119. 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Kidney Int. 1984;26(1):72-80. Belcher JM, Parikh CR, Garcia-Tsao G. Acute kidney injury in patients with cirrhosis: perils and promise. Clin Gastroenterol Hepatol. 2013;11(12):1550-1558. Allegretti AS, Solà E, Ginès P. Clinical application of kidney biomarkers in cirrhosis. Am J Kidney Dis. 2020 Jul 1;S0272-6386(20)30691-0. Sorensen-Zender I, Beneke J, Schmidt BM, Menne J, Haller H, Schmitt R. Zinc-alpha2-glycoprotein in patients with acute and chronic kidney disease. BMC Nephrol. 2013;14:145. Lim SC, Liying DQ, Toy WC, Wong M, Yeoh LY, Tan C,et al: Adipocytokine zinc alpha2 glycoprotein (ZAG) as a novel urinary biomarker for normo-albuminuric diabetic nephropathy. Diabet Med. 2012;29(7):945-949. Bing C, Trayhurn P: New insights into adipose tissue atrophy in cancer cachexia. Proc Nutr Soc 2009;68:385-392. Sakaida I, Terai S, Kurosaki M, Okada M, Hirano T, Fukuta Y. Real-world effectiveness and safety of tolvaptan in liver cirrhosis patients with hepatic edema: results from a post-marketing surveillance study (START study). J Gastroenterol 2020;55(8):800-810. Tables Table 1. Characteristics of 113 liver cirrhotic patients. Parameters All Without ascites With ascites Non-treatment Treatment p † n = 113 n = 46 n = 22 n = 45 Age (years) 68.0 (60.0-75.0) 66.5 (58.0-72.8) 74.0 (66.3-80.8) 68.0 (61.0-76.0) 0.1117 Gender, Male : Female 69 : 44 29 : 17 14 : 8 26 : 19 0.6939 Bodyweight (kg) 58.1 (51.3-66.7) 62.3 (51.3-72.7) 57.0 (53.4-61.6) 56.6 (51.0-63.6) 0.7620 Body mass index (kg/m 2 ) 23.6 (20.8-25.3) 24.0 (22.5-25.8) 22.3 (20.1-25.0) 22.1 (19.5-24.3) 0.7010 Psoas muscle index (cm 2 /m 2 ) 5.6 (4.7-7.0) 6.1 (4.7-7.4) 5.6 (4.8-6.4) 5.2 (4.2-6.2) 0.2651 HCV/HBV/HCV+AL/AL/ NASH /others 56/7/4/23/13/10 28/2/0/10/2/4 11/0/1/3/4/3 17/4/3/10/7/4 - presence of HCC, yes: no 61 : 52 23 : 23 10 : 12 28 : 17 0.6045 Ratio of using diuretic drugs (%) 26 45 100 - Dose of diuretic drugs (n) Tolvaptan (0mg/3.75mg/7.5mg) 68 / 37 / 8 46 / 0 / 0 22 / 0 / 0 0 / 37 / 8 - Furosemide (0mg/10mg/20mg/40mg/80mg) 62/4/28/14/5 40/0/4/2/0 16/1/4/0/1 6/3/20/12/4 <0.0001 Spironolactone (0mg/25mg/50mg/100mg) 55 / 26 / 28 / 4 38 / 4 / 3 / 1 14 / 4 / 3 / 1 3 / 18 / 22 / 2 <0.0001 Grade of ascites (1 / 2 / 3) 37 / 22/ 8 0 / 0 / 0 17 / 2 / 3 20 / 20 / 5 - AST (U/L) 45.0 (31.0-70.0) 37.0 (28.3-54.5) 35.5 (28.0-62.5) 55.0 (42.0-87.0) 0.0014 ALT (U/L) 29.0 (17.0-41.0) 28.0 (17.0-41.8) 29.5 (15.0-34.3) 29.0 (23.0-42.0) 0.2421 Albumin (g/dL) 3.2 (2.8-3.7) 3.6 (3.3-4.1) 3.3 (3.0-3.7) 2.9 (2.6-3.1) 0.0010 Total Bilirubin (mg/dL) 1.2 (0.7-1.9) 1.1 (0.7-1.4) 0.8 (0.7-1.8) 1.5 (0.8-2.7) 0.0210 Prothrombin time (%) 72.0 (60.9-82.4) 75.6 (64.1-84.0) 74.2 (61.5-85.5) 67.4 (55.1-78.4) 0.1297 Child-Pugh score 7.0 (6.0-9.0) 5.5 (5.0-6.8) 7.5 (6.3-9.0) 8.0 (8.0-10.0) 0.0083 ALBI score -1.9 (-2.4- -1.5) -2.4 (-2.6- -1.9) -2.0 (-2.7- -1.3) -1.5 (-1.8- -1.2) 0.0004 FIB4-index 6.3 (3.8-9.3) 5.2 (3.5-7.9) 5.0 (3.7-8.4) 8.0 (5.5-10.6) 0.0343 MELD score 16.0 (14.6-18.2) 15.0 (14.0-16.1) 16.5 (15.8-20.0) 16.9 (15.0-19.3) 0.6643 MELD-Na score 18.3 (15.5-21.5) 15.6 (13.5-17.4) 17.6 (16.5-21.7) 20.3 (18.4-23.5) 0.0557 Creatinine (mg/dL) 0.8 (0.6-1.0) 0.7 (0.6-0.8) 0.9 (0.8-1.1) 0.8 (0.7-1.0) 0.2143 BUN (mg/dL) 15.5 (11.7-22.0) 14.0 (10.0-18.0) 18.0 (13.5-27.2) 18.5 (13.0-25.0) 0.6594 eGFR (mL/min/1.73m 2 ) 69.0 (59.0-104.4) 75.1 (59.3-93.6) 58.8 (34.4-74.5) 61.1 (46.7-87.7) 0.4999 GFR (MDRD-6) ( mL/min) 84.3 (70.4-126.4) 99.6 (80.4-128.2) 75.5 (53.0-95.0) 77.2 (54.0-95.7) 0.5887 Serum sodium (mEq/L) 138 (134-140) 140 (139-141) 138 (136-139) 134 (131-138) 0.00 43 CRP (mg/dL) 0.3 (0.1-1.3) 0.1 (0.0-0.3) 0.2 (0.1-1.0) 1.2 (0.4-3.4) <0.0001 Copeptin (pmol/L) 6.6 (3.6-14.2) 4.2 (2.6-6.7) 8.0 (5.2-15.2) 10.7 (5.4-19.7) 0.5002 ZAG (μg/mL) 29.2 (24.3-37.6) 27.4 (22.5-32.0) 37.9 (26.9-45.6) 32.1 (24.7-41.1) 0.1797 NGAL (ng/mL) 61.0 (30.1-104.2) 30.3 (18.4-53.3) 88.9 (43.9-114.5) 82.9 (54.8-149.8) 0.6595 Cystatin C (mg/dL) 1.1 (0.9-1.3) 1.0 (0.8-1.2) 1.2 (1.0-1.5) 1.1 (0.9-1.4) 0.2854 L-FABP (ng/mL) 8.1 (3.8-13.8) 5.3 (2.2-13.3) 8.4 (3.8-10.8) 9.7 (5.5-19.3) 0.2119 † Mann–Whitney U test (Non-treatment vs. Treatment). HCV, hepatitis C virus; HBV, hepatitis B virus; AL, alcohol; NASH, nonalcoholic steatohepatitis; HCC, hepatocellular carcinoma; AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALBI, albumin-bilirubin; FIB4-index, fibrosis-4; MELD, Model for End-Stage Liver Disease; BUN, blood urea nitrogen; eGFR, estimated glomerular filtration rate; MDRD-6, the 6-variable Modification of Diet in Renal Disease; CRP, C-reactive protein; ZAG, zinc-α2-glycoprotein; NGAL, neutrophil gelatinase-associated lipocalin; L-FABP, Liver-type fatty acid–binding protein. All data are expressed as median (first quartile-third quartile). Table 2. Correlation between serum copeptin, ZAG, cystatin C, NGAL, L-FABP levels and clinical parameters in 113 liver cirrhotic patients. Parameter Copeptin ZAG Cystatin C NGAL L-FABP r p ※ r p ※ r p ※ r p ※ r p ※ Age -0.0127 0.8930 0.1691 0.0734 0.2202 0.0191 0.1902 0.0436 0.0945 0.3194 Gender -0.0623 0.5120 0.1474 0.1191 -0.0729 0.4429 -0.0762 0.4223 0.1380 0.1448 Bodyweight -0.0417 0.6683 -0.2497 0.0092 -0.1195 0.2182 -0.0907 0.3507 -0.1156 0.2336 BMI -0.0504 0.6100 -0.3675 0.0001 -0.0453 0.6460 -0.0796 0.4197 -0.1695 0.0839 PMI -0.1605 0.1070 -0.0610 0.5425 -0.1211 0.2252 -0.0484 0.6293 -0.0676 0.4998 AST 0.1947 0.0388 -0.2462 0.0086 -0.0894 0.3464 0.0226 0.8120 0.3504 0.0001 ALT 0.0521 0.5835 -0.1792 0.0575 -0.0647 0.4959 -0.0707 0.4567 0.4015 < 0.0001 Total bilirubin 0.1580 0.0947 -0.3090 0.0009 -0.1947 0.0388 -0.0392 0.6804 -0.0671 0.4800 Albumin -0.3152 0.0007 -0.0022 0.9819 -0.1280 0.1766 -0.4398 < 0.0001 -0.2312 0.0137 Prothrombin time -0.1141 0.2311 0.2386 0.0113 -0.1582 0.0957 -0.0752 0.4308 -0.0918 0.3357 Creatinine 0.2197 0.0199 0.4322 < 0.0001 0.5714 < 0.0001 0.4085 < 0.0001 0.3497 0.0001 BUN 0.2575 0.0059 0.5037 < 0.0001 0.5074 < 0.0001 0.3703 < 0.0001 0.4430 < 0.0001 eGFR -0.2490 0.0078 -0.3451 0.0002 -0.6086 < 0.0001 -0.4481 < 0.0001 -0.2788 0.0028 GFR (MDRD-6) -0.3018 0.0012 -0.3731 < 0.0001 -0.6077 < 0.0001 -0.4949 < 0.0001 -0.3412 0.0002 Serum sodium -0.1200 0.2181 -0.1232 0.2062 -0.0285 0.7711 -0.2553 0.0080 -0.1790 0.0650 CRP 0.2701 0.0047 0.3677 <0.0001 0.0518 0.5944 0.4291 < 0.0001 0.2281 0.0176 Copeptin - - 0.1969 0.0366 0.3104 0.0008 0.3182 0.0006 0.1709 0.0703 ZAG 0.1969 0.0366 - - 0.2701 0.0038 0.3634 < 0.0001 0.1735 0.0662 Cystatin C 0.3104 0.0008 0.2701 0.0038 - - 0.4913 < 0.0001 0.4468 < 0.0001 NGAL 0.3182 0.0006 0.3634 < 0.0001 0.4913 < 0.0001 - - 0.3105 0.0008 L-FABP 0.1709 0.0703 0.1735 0.0662 0.4468 < 0.0001 0.3105 0.0008 - - Child-Pugh score 0.3819 <0.0001 -0.0271 0.7754 0.1468 0.1208 0.3876 < 0.0001 0.2143 0.0227 ALBI score 0.3366 0.0003 -0.0921 0.3322 0.0656 0.4901 0.3750 < 0.0001 0.2078 0.0272 MELD score 0.3057 0.0010 0.3338 0.0003 0.5595 < 0.0001 0.4498 < 0.0001 0.2839 0.0024 MELD-Na score 0.3187 0.0008 0.3135 0.0010 0.4342 < 0.0001 0.5188 < 0.0001 0.3450 0.0003 ※ Spearman's rank correlation coefficient. BMI, body mass index; PMI, psoas muscle index; AST, aspartate aminotransferase; ALT, alanine aminotransferase; BUN, blood urea nitrogen; eGFR, estimated glomerular filtration rate; MDRD-6, the 6-variable Modification of Diet in Renal Disease; CRP, C-reactive protein; ZAG, zinc-α2-glycoprotein; NGAL, neutrophil gelatinase-associated lipocalin; L-FABP, Liver-type fatty acid–binding protein; ALBI, albumin-bilirubin; MELD, Model for End-Stage Liver Disease. Table 3. Characteristics of patients treated with Tolvaptan. Parameters Responders Non-responders p † n = 19 n = 19 Age (years) 65.0 (60.5-74.0) 68.0 (58.0-73.5) 0.7589 Gender, Male : Female 13 : 6 11 : 8 0.5795 Bodyweight (kg) 61.2 (55.6-64.4) 57.0 (50.9-63.1) 0.4229 Body mass index (kg/m 2 ) 21.9 (19.3-24.8) 22.5 (19.2-24.7) 0.8315 Psoas muscle index (cm 2 /m 2 ) 5.7 (4.5-7.1) 5.3 (4.6-5.9) 0.5534 HCV/HBV/HCV+AL/AL/NASH/others 7/0/2/6/2/2 5/4/1/4/4/1 - presence of HCC, yes: no 11 : 8 12 : 7 0.7862 Dose of diuretic drugs Tolvaptan (3.75 mg/7.5 mg) 15 / 4 17 / 2 0.6976 Furosemide (mg) 20 (5-35) 20 (20-40) 0.8217 Spironolactone (mg) 50 (25-50) 25 (25-50) 0.2548 Albumin (g/dL) 2.9 (2.6-3.1) 2.8 (2.7-3.2) 0.8490 Total Bilirubin (mg/dL) 1.8 (1.2-3.1) 1.4 (0.8-2.3) 0.1361 Child-Pugh score 8.0 (8.0-10.5) 8.0 (7.5-10.0) 0.3679 ALBI score -1.4 (-1.8- -1.1) -1.5 (-1.8 - -1.3) 0.7371 FIB4-index 7.8 (6.3-10.1) 8.3 (5.0-10.4) 0.9534 MELD score 16.6 (15.0-19.5) 17.4 (15.8-20.0) 0.3655 MELD-Na score 20.3 (18.9-22.5) 21.3 (18.0-23.7) 0.9302 Creatinine (mg/dL) 0.8 (0.6-0.9) 0.9 (0.7-1.1) 0.2932 BUN (mg/dL) 13.0 (10.0-19.0) 23.0 (18.8-27.5) 0.0014 eGFR (mL/min/1.73m 2 ) 69.4 (50.2-81.8) 58.2 (45.4-76.6) 0.2093 GFR (MDRD-6) (mL/min) 82.8 (60.1-102.7) 60.2 (51.8-88.6) 0.0904 Serum sodium (mEq/L) 134 (132-137) 135 (132-139) 0.2909 CRP (mg/dL) 1.2 (0.4-2.7) 1.9 (0.4-3.8) 0.5018 Copeptin (pmol/L) 6.6 (4.0-14.0) 14.0 (9.0-27.2) 0.0265 ZAG (μg/mL) 27.4 (23.1-33.2) 37.4 (32.8-44.9) 0.0142 NGAL (ng/mL) 95.1 (59.5-162.0) 82.9 (61.2-140.6) 1.0000 Cystatin C (mg/dL) 1.1 (0.9-1.3) 1.1 (0.8-1.4) 0.9534 L-FABP (ng/mL) 8.5 (4.4-17.5) 11.5 (8.1-17.9) 0.2429 AFP (ng/mL) 9 (5-335) 8 (3-67) 0.4362 DCP (mAU/mL) 498 (39-8039) 2816 (157-9950) 0.5065 † Mann–Whitney U test, HCV, hepatitis C virus; HBV, hepatitis B virus; AL, alcohol; NASH, nonalcoholic steatohepatitis; HCC, hepatocellular carcinoma; ALBI, albumin-bilirubin; FIB4-index, fibrosis-4; MELD, Model for End-Stage Liver Disease; BUN, blood urea nitrogen; eGFR, estimated glomerular filtration rate; MDRD-6, the 6-variable Modification of Diet in Renal Disease; CRP, C-reactive protein; ZAG, zinc-α2-glycoprotein; NGAL, neutrophil gelatinase-associated lipocalin; L-FABP, Liver-type fatty acid–binding protein; AFP, α-fetoprotein; DCP, Des-γ-carboxy prothrombin. Responders were defined as decompensated liver cirrhosis patients in whom tolvaptan was an effective treatment for ascites. All data are expressed as median (first quartile-third quartile). Table 4. Predictors contributing to the effect of Tolvaptan in the treatment for ascites Predictors cutoff ROCAUC Sensitivity Specificity Univariate analysis Multivariate analysis OR 95%CI p § OR 95%CI p § BUN 18.3 0.8047 79 74 10.50 2.54 → 53.39 0.0009 7.43 1.20 → 64.69 0.0306 Copeptin 10.1 0.7119 68 74 6.07 1.57 → 27.02 0.0083 9.12 1.54 → 91.14 0.0136 ZAG 32.4 0.7341 79 74 10.50 2.54 → 53.39 0.0009 7.43 1.20 → 64.69 0.0306 HCC - - - - 1.24 0.34 → 4.69 0.7399 - - - ROCAUC, receiver operating characteristic area under the curve. p § ; Logistic regression analysis; OR, odds ratio; 95%CI, 95% confidence interval BUN, blood urea nitrogen; ZAG, zinc-α2-glycoprotein; HCC, hepatocellular carcinoma. Supplementary Files Suppl.1Patientflow.jpg The patient flow LC, liver cirrhosis; TIPS, transjugular intrahepatic portosystemic shunt; LVP, large volume paracentesis; CART, cell-free and concentrated ascites reinfusion therapy Cite Share Download PDF Status: Published Journal Publication published 01 Nov, 2021 Read the published version in Internal Medicine → Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-52252","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":2954918,"identity":"c6674127-089e-4f81-bbae-d54a1064d992","order_by":0,"name":"Ryuta Shigefuku","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABQklEQVRIie2Rv0rEQBCHJxwkTdR2D8G8wh4B8TBvYrPLwaW52NhYiEYCsQnaRnwJq2B3kcDZ5AFynIVLGsvYRbRw8kcISRBLwXzFkB3y7cwvARgY+IsQyQYwgIJiSyErW9wu+t8vyP3KHBU1hN8qRSkUwiCsWuznvbQ7x3nNWKTTdfoSigc42lFml5m0ONjDS6Qsh+3jlkKfH92pz6J9upnTkMdg3XrCIVJAdFRGYw/kk7ZCuKtv5ZFBNwsIuQvWfYIVFb5MGOxiljJaczEflU+GyjqulGWtXNg45aNHgYQ7KRSLJWo9hVQKw8XkvikU75Q8ZurjuMjiEsuPMQsPyMRWhTv1aCeL5ptplrPDyfVTJMS7a1g3V6bI3oJzDZRZlOSnq/YXQ2TSONTPrKzFX6Yr1lVGWbfX4KxHGRgYGPhffAHTHHdqnn87PgAAAABJRU5ErkJggg==","orcid":"https://orcid.org/0000-0002-6738-4382","institution":"Mie University Graduate School ofMedicine","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Ryuta","middleName":"","lastName":"Shigefuku","suffix":""},{"id":2954919,"identity":"68c3756e-8d9b-4576-bbc6-1e408c66afdb","order_by":1,"name":"Motoh Iwasa","email":"","orcid":"","institution":"Mie University Graduate School of Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Motoh","middleName":"","lastName":"Iwasa","suffix":""},{"id":2954920,"identity":"03366ff2-d47c-4a21-9179-2b6e40698815","order_by":2,"name":"Akiko Eguchi","email":"","orcid":"","institution":"Mie University Graduate School of Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Akiko","middleName":"","lastName":"Eguchi","suffix":""},{"id":2954921,"identity":"588816e9-084d-44a2-a721-feed41705f49","order_by":3,"name":"Mina Tempaku","email":"","orcid":"","institution":"Mie University School of Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Mina","middleName":"","lastName":"Tempaku","suffix":""},{"id":2954922,"identity":"db623f28-cc32-4191-82a3-174f1946e149","order_by":4,"name":"Yasuyuki Tamai","email":"","orcid":"","institution":"Mie University School of Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Yasuyuki","middleName":"","lastName":"Tamai","suffix":""},{"id":2954923,"identity":"dba037f3-6290-4c35-a9b1-85bddf682508","order_by":5,"name":"Tatsuya Suzuki","email":"","orcid":"","institution":"Mie University Graduate School of Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Tatsuya","middleName":"","lastName":"Suzuki","suffix":""},{"id":2954924,"identity":"aee31ece-fc4e-4224-8fdf-e70f1133ea86","order_by":6,"name":"Yoshiyuki Takei","email":"","orcid":"","institution":"Mie University Graduate School of Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Yoshiyuki","middleName":"","lastName":"Takei","suffix":""}],"badges":[],"createdAt":"2020-08-01 11:14:32","currentVersionCode":2,"declarations":"","doi":"10.21203/rs.3.rs-52252/v2","doiUrl":"https://doi.org/10.21203/rs.3.rs-52252/v2","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.2169/internalmedicine.7291-21","type":"published","date":"2021-11-01T22:54:15+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":2811641,"identity":"c8f5ff66-12b3-40b0-9d8f-74bae1472087","added_by":"auto","created_at":"2020-10-06 18:48:51","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":63065,"visible":true,"origin":"","legend":"Serum copeptin levels were correlated with liver and kidney function in patients with cirrhosis. Serum ZAG levels were correlated with bodyweight, BMI and kidney function in patients with cirrhosis. Correlation between serum copeptin levels and Bodyweight (A), BMI (B), CRP (C), albumin (D), creatinine (E) or BUN (F). Correlation between serum ZAG levels and Bodyweight (G), BMI (H), CRP (I), albumin (J), creatinine (K) or BUN (L). ZAG, zinc-α2-glycoprotein; BMI, body mass index; CRP, C-reactive protein; BUN, blood urea nitrogen","description":"","filename":"Figure1.png","url":"https://assets-eu.researchsquare.com/files/rs-52252/v2/02446b6c1ae77b9b5822b485.png"},{"id":2811642,"identity":"28c6c503-78a9-4a56-ab55-5495291f23d5","added_by":"auto","created_at":"2020-10-06 18:48:51","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":23832,"visible":true,"origin":"","legend":"Predictors contributing to the effect of tolvaptan in treatment for ascites. Serum BUN (A), copeptin (B), ZAG (C), cystatin C (D), NGAL (E) and L-FABL (F) levels in the Responder and Non-responder to tolvaptan.\nBUN, blood urea nitrogen; ZAG, zinc-α2-glycoprotein; NGAL, neutrophil gelatinase-associated lipocalin; L-FABP, liver-type fatty acid-binding protein\n","description":"","filename":"Figure2.png","url":"https://assets-eu.researchsquare.com/files/rs-52252/v2/39933092d3397c2423ea5ecc.png"},{"id":15070419,"identity":"97c3fd90-0a23-4380-ad65-28ac35cb08b3","added_by":"auto","created_at":"2021-10-31 22:54:23","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":693564,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-52252/v2/564e55e4-7621-439c-8fda-d688fad30666.pdf"},{"id":2811640,"identity":"b740d094-663e-4991-adee-8e10d7192d99","added_by":"auto","created_at":"2020-10-06 18:48:51","extension":"jpg","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":128062,"visible":true,"origin":"","legend":"The patient flow\nLC, liver cirrhosis; TIPS, transjugular intrahepatic portosystemic shunt; LVP, large volume paracentesis; CART, cell-free and concentrated ascites reinfusion therapy\n","description":"","filename":"Suppl.1Patientflow.jpg","url":"https://assets-eu.researchsquare.com/files/rs-52252/v2/8012dba786abacf40c76c486.jpg"}],"financialInterests":"","formattedTitle":"Serum copeptin and zinc-α2-glycoprotein levels are novel biomarkers of tolvaptan treatment in decompensated cirrhotic patients with ascites.","fulltext":[{"header":"Background","content":"\u003cp\u003eArginine vasopressin (AVP) is a potent antidiuretic hormone in the human body. Despite the clinical relevance of AVP in maintaining fluid balance and vascular tone, measurement of the mature form of AVP is difficult due to small size (9 amino acids), short half-life, and its ability to bind platelets \u003csup\u003e1\u003c/sup\u003e. Copeptin, a 39-amino acid glycopeptide that comprises the C-terminal part of the AVP precursor, was found to be a stable and sensitive surrogate marker for AVP release \u003csup\u003e2\u003c/sup\u003e. Current reports have demonstrated that a high serum copeptin concentration predicts survival hospitalized liver cirrhosis (LC) patients, independent of liver-specific scoring systems \u003csup\u003e3\u003c/sup\u003e, suggesting that copeptin has the potential to be a biomarker of disease progression and prognosis in LC \u003csup\u003e4\u003c/sup\u003e. Zinc-alpha-2-glycoperotein (ZAG) is a 41-kDa glycoprotein synthesized by epithelial cells and adipocytes and plays a role in lipid metabolism, cell cycling and cancer progression. Serum ZAG levels has been reported as a biomarker of renal injury and can predict mortality in hemodialysis patients \u003csup\u003e5\u003c/sup\u003e. However, these changes in serum ZAG levels have not been reported in LC patients with ascites.\u003c/p\u003e\n\u003cp\u003eThere are several established markers of renal function, such as serum cystatin C, neutrophil gelatinase-associated lipocalin (NGAL), and liver-type fatty acid binding protein (L-FABP). Urea NGAL is established as a clinical biomarker for acute renal injury \u003csup\u003e6\u003c/sup\u003e based on NGAL function of a kidney protector \u003csup\u003e7\u003c/sup\u003e. Urine L-FABP levels derived from proximal tubular epithelial cells are elevated in renal tubular injury episodes and are therefore used as an established marker of several kidney diseases, including acute kidney injury and chronic kidney diseases \u003csup\u003e8\u003c/sup\u003e. We have reported that serum NGAL and serum L-FABP levels are prognostic factors for survival in chronic liver diseases \u003csup\u003e9,10\u003c/sup\u003e.\u003c/p\u003e\n\u003cp\u003eAscites is the most frequent complication of LC and refractory ascites has a negative prognostic implication in the natural progression of LC. Tolvaptan is a novel, orally administered, selective vasopressin V\u003csub\u003e2\u003c/sub\u003e-receptor antagonist that downregulates the expression of aquaporin-2 in the renal collecting duct. Current research has uncovered a promising role for tolvaptan as an add-on treatment in patients with hepatic ascites resistant to furosemide and/or spironolactone, as it is able to decrease body weight and alleviate edema \u003csup\u003e11,12\u003c/sup\u003e. However, the effect of tolvaptan is highly variable among patients with approximately one half of the patient cohort responding to the drug \u003csup\u003e11\u003c/sup\u003e. Blood urea nitrogen (BUN) \u003csup\u003e11\u003c/sup\u003e and C-reactive protein (CRP) \u003csup\u003e12\u003c/sup\u003e are recognized for differentiating diagnoses between Responders and Non-responders for tolvaptan, but these factors are insufficient, thus additional biomarkers are needed. Recently, in addition to the aforementioned studies, several studies have also reported Responders to tolvaptan led to improvement of long-term survival rates in cirrhotic patients with ascites \u003csup\u003e13,14\u003c/sup\u003e. Therefore, the aim of this study is to assess the correlation between the efficacy of tolvaptan and treatment related factors, including serum copeptin, ZAG, cystatin C, NGAL and L-FABP levels in LC patients with ascites.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003e\u003cstrong\u003eHuman samples\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe study protocol was approved by the Clinical Research Ethics Review Committee of Mie University Hospital. This study was performed retrospectively on stored samples, and patients could opt out of their data. In this study, we enrolled 113 LC patients (69 males and 44 females) with a median age of 68.0 (60.0-75.0) years who could be analyzed between November 2013 and September 2016 at Mie University hospital. Patients positive for hepatitis B surface antigen were diagnosed HBV infection, whereas those positive for anti-hepatitis C virus (HCV) were diagnosed HCV infection. Alcoholic cirrhosis defined as the presence of alcohol consumption \u0026gt;60 g/day. Nonalcoholic steatohepatitis was diagnosed based on pathological findings or fatty liver without any other evident causes of chronic liver diseases (viral, autoimmune, genetic, etc.). We divided the 113 LC patients into three groups: without ascites group (n=46), with ascites non-treatment group (n=22) and with ascites treatment group (n=45) (Table 1). LC was diagnosed based on morphologic changes of the liver such as hypertrophy of the left lateral and caudate lobes, or atrophy of the right posterior hepatic lobe on ultrasonography and through blood tests, and/or computed tomography, magnetic resonance imaging, FibroScan (Echosens, French) results, and esophageal varix by endoscopy, as is the general protocol. FibroScan cannot be used in individuals with ascites, therefore, it was performed for assessing liver fibrosis mainly in chronic hepatitis or early cirrhosis. The definition of idiopathic portal hypertension/portal-sinusoidal vascular disorder was based on the absence of characteristic cirrhosis and known causes of liver disease. Decompensated cirrhosis was diagnosed as it presents with a series of clinical and laboratory signs, e.g. ascites, encephalopathy, gastrointestinal bleeding, thrombocytopenia or hypoalbuminemia. HCC was diagnosed based on histological findings or typical imaging characteristics. Body mass index (BMI) was calculated as weight (kg)/height (m) squared. BMI was not adjusted for ascites. We provided body composition analysis by measuring the psoas muscle index (PMI) due to the limitations of BMI in patients with ascites. Using cross-sectional CT at the level of transverse process of lumbar vertebra L3, the bilateral psoas muscle area was identified. PMI (cm\u003csup\u003e2\u003c/sup\u003e/m\u003csup\u003e2\u003c/sup\u003e) was defined by normalizing psoas muscle area (cm\u003csup\u003e2\u003c/sup\u003e)/height (m) squared. Patients who had other malignancies within the past 3 years, spontaneous bacterial peritonitis, hepatic encephalopathy (coma scale score\u0026thinsp;\u0026ge;\u0026thinsp;II), heart failure (the New York Heart Association defined category \u0026ge;class II), human immunodeficiency virus infection, pregnancy, or psychiatric problems were deemed to be unsuitable for clinical study.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAlgorithm for treatment of ascites and definition of responder and non-responder\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAs a general rule, the follow-up examinations included routine physical examinations and biochemical tests and diagnostic imagining studies including ultrasonography. All treatments of ascites were performed following the Japanese practical guidelines for LC in 2015 as possible \u003csup\u003e15\u003c/sup\u003e. Patients with grade 1 mild ascites do not need diuretics and a low sodium diet. For patients with grade 2 moderate ascites, treatment begins with the administration of spironolactone at 25-50\u0026thinsp;mg /day, then, in the absence of an effect, furosemide is added at 20 mg/day. Tolvaptan was recommended adding on other diuretics including 25-50\u0026thinsp;mg/day spironolactone and/or 20-40\u0026thinsp;mg/day furosemide, especially in patients with sustained hyponatremia.\u003c/p\u003e\n\u003cp\u003eWe divided the patients into two tolvaptan treatment groups: Responders and Non-responders. The Non-responder group was defined as patients with weight loss of \u0026lt;1.5 kg/week after receiving tolvaptan or performing paracentesis within the first week\u003csup\u003e 12\u003c/sup\u003e. All patients continued to take the same prescribed doses of furosemide and spironolactone within the first week\u003csup\u003e 16\u003c/sup\u003e.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eSerum preparation\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eIn the without ascites group and with ascites non-treatment group, serum samples were collected when patients showed up at the hospital. In the with ascites treatment group, serum collection was immediately before the administration of tolvaptan. Albumin (g/dL), total bilirubin (mg/dL), sodium (mEq/L), creatinine (mg/dL), BUN (mg/dL), CRP (mg/dL), \u0026alpha;-fetoprotein (AFP; ng/mL) and des-\u0026gamma;-carboxy prothrombin (DCP; mAU/mL) were measured. Serum were kept at -80℃ until copeptin (pmol/L), ZAG (\u0026mu;g/dL), cystatin C (mg/dL), NGAL (ng/mL) and L-FABP (ng/mL) measurements, using an automated copeptin immunofluorescent assay kit (Thermo Fisher Scientific Inc., Tokyo) \u003csup\u003e2\u003c/sup\u003e, ZAG enzyme-linked immunosorbent assay (ELISA) kit (BioVendor, Czech Republic), cystatin C ELISA kit (R\u0026amp;D systems, Minneapolis, MN), NGAL ELISA kit (R\u0026amp;D systems, Minneapolis, MN) and high-sensitivity human L-FABP ELISA kit (CMIC Holdings Co., Ltd., Tokyo), respectively. The Child-Pugh score, albumin-bilirubin (ALBI) score \u003csup\u003e17\u003c/sup\u003e, the fibrosis index based on 4 factors (FIB-4) \u003csup\u003e18\u003c/sup\u003e, model for end-stage liver disease (MELD) score, MELD-Na score and estimated glomerular filtration rate (eGFR) with Cockcroft and Modification of Diet in Renal Disease\u0026nbsp;(MDRD) formula were calculated.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatistical analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll data are expressed as median and range. Data were analyzed using the Mann-Whitney \u003cem\u003eU\u003c/em\u003e test in two groups and one-way analysis of variance for comparison of continuous variables. The relationship between serum copeptin, ZAG, cystatin C, NGAL, L-FABP levels and clinical data were examined using Spearman\u0026rsquo;s rank correlation coefficient. For each continuous variable, the optimal cutoff value that maximized the sum of sensitivity and specificity was selected using receiver operating characteristic (ROC) analysis for survival. A logistic regression analysis was utilized for the multivariate analysis in order to evaluate the relationship between effect of tolvaptan and clinical data. Only variables deemed to be significant (p\u0026lt;0.1) in the univariate analysis were included in the subsequent multivariate analysis. The statistical analyses were performed using JMP software program (SAS Institute, Cary, NC, USA) for univariate and multivariate logistic regression analysis. Differences were considered to be significant at p\u0026lt;0.05.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cstrong\u003eClinical characteristics of patients with or without tolvaptan \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eCohort creation were summarized in the patient flow (supplementary Figure 1). In this study, we divided the 113 LC patients into 3 groups : without ascites group, with ascites non-treatment group or with ascites treatment group. Table 1 shows the comparison of baseline clinical characteristics and laboratory variables between non-treatment group and treatment group. In the treatment group, AST, total bilirubin, CRP, the Child-Pugh score, ALBI score and FIB4-index were significantly increased, while serum albumin and sodium levels were reduced, suggesting that patients treated with tolvaptan demonstrated more advanced liver diseases. In the treatment group, the dose of diuretics drugs (Furosemide and/or Spironolactone) was significantly higher. In contrast, there were no obvious differences in age, gender, bodyweight, BMI, PMI, prevalence of HCC, ALT, prothrombin time, MELD score, MELD-Na score, creatinine, BUN, eGFR (Cockcroft and MDRD-6), copeptin, ZAG, NGAL, L-FABP and cystatin C between the two groups (Table 1).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCorrelation of copeptin, ZAG, cystatin C, NGAL and L-FABP to clinical parameters in all patients\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe correlations between copeptin, ZAG, cystatin C, NGAL or L-FABP and clinical parameters in LC patients were shown in Table 2. Copeptin was strongly correlated with mainly hepatic function including albumin (p=0.0007; Figure 1-D), Child-Pugh score (p\u0026lt;0.0001), ALBI score (p=0.0003) and CRP (p=0.0047; Figure 1-C). In contrast, ZAG was more strongly correlated with renal function including creatinine (p\u0026lt;0.0001), BUN (p\u0026lt;0.0001) and GFR (MDRD-6) (p\u0026lt;0.0001) (Table 2; Figure 1-K and L). In addition, ZAG was correlated with bodyweight (p=0.0092; Figure 1-G), BMI (p=0.0001; Figure 1-H) and CRP (p\u0026lt;0.0001; Figure 1-I). Cystatin C was significantly correlated with age (p=0.0191), renal parameters (creatinine, BUN and eGFR: p\u0026lt;0.0001), copeptin (p=0.0008), NGAL (p\u0026lt;0.0001) and L-FABP (p\u0026lt;0.0001) (Table 2). NGAL and L-FABP were significantly correlated with indicators of both renal function and hepatic function (Table 2). MELD-Na score significantly correlated with all, copeptin (p=0.0008), ZAG (p=0.001), cystatin C (p\u0026lt;0.0001), NGAL (p\u0026lt;0.0001) and L-FABP (p=0.0003).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eBackground comparison between Responders and Non-responders to tolvaptan\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eIn this study, we excluded 7 from 45 cases for which tolvaptan efficacy could not be determined because of transferring hospitals, lack of weight data or with other treatment such as albumin transfusion, large volume paracentesis, and cell-free and concentrated ascites reinfusion therapy (Supplementary Figure 1). We enrolled 38 decompensated LC patients with ascites (24 males and 14 females) with a median age of 66.0 (59.5-73.0) years. We divided the 38 patients into two tolvaptan treatment groups: Responders and Non-responders. There were no obvious differences in age, gender, bodyweight, BMI, PMI, presence of HCC, AFP, DCP, dose of diuretic drugs, albumin, total bilirubin, Child-Pugh score, ALBI score, FIB4-index, MELD score/MELD-Na score, creatinine, eGFR, serum sodium, cystatin C, NGAL and L-FABP between the two groups (Table 3; Figure 2-D, E and F). In contrast, BUN, copeptin and ZAG levels were significantly higher in Non-responders when compared to the Responders group (respectively, p=0.0014, p=0.0265, p=0.0142) (Table 3; Figure 2-A, B and C). We further examined except for HCC, because HCC have pro-inflammatory condition. BUN (p=0.015) was significantly higher in Non-responders (n=7) when compared to the Responders (n=8) in patients without HCC. In contrast, copeptin and ZAG levels were not higher in Non-responders in patients without HCC.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePredictors contributing to the effect of tolvaptan in treatment for ascites\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e We calculated the cutoff values, area under the ROC curve, sensitivity and specificity of BUN, copeptin and ZAG using ROC analysis. The cutoff values ascertained from our analyses of BUN, copeptin and ZAG were 18.3mg/dL, 10.1pmol/L and 32.4 \u0026mu;g/mL, respectively (Table 4). The contribution of HCC, BUN, copeptin and ZAG were evaluated using multivariate logistic regression analysis. We found serum BUN (odds ratio 7.43, p=0.0306), copeptin (odds ratio 9.12, p=0.0136) and ZAG (odds ratio 7.43, p=0.0306) levels to be the significant predictors contributing to the efficacy of tolvaptan in the treatment for ascites; however, presence of HCC was not selected (Table 4).\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eIn this study, we revealed for the first time that serum copeptin and ZAG levels were significantly increased in the tolvaptan treatment Non-responders group when compared to the Responders group. In addition, we indicated that serum BUN, copeptin and ZAG levels were independent predictors of the overall response to tolvaptan therapy. We further showed that serum creatinine and cystatin C levels were not predictive of patient response to tolvaptan, thus confirming the findings reported by others \u003csup\u003e11,12\u003c/sup\u003e. In LC, arteriolar vasodilation causes underfilling of the systemic arterial vascular space, and the decrease in the effective blood volume leads to a decrease in arterial pressure \u003csup\u003e19\u003c/sup\u003e. Consequently, activation of the renin-angiotensin-aldosterone system, sympathetic nervous system and the release of antidiuretic hormone take place as the body attempts to restore normal blood pressure homeostasis \u003csup\u003e20\u003c/sup\u003e. The main physiological function of AVP is antidiuresis, thereby regulating systemic osmotic pressure. Plasma AVP levels are normally regulated by plasma osmotic pressure and have been found to be elevated in LC patients with ascites, as reported by P\u0026eacute;rez-Ayuso RM \u003csup\u003e21\u003c/sup\u003e. However, there has been no study to date exploring whether the effect of tolvaptan is related to plasma AVP or pro-AVP (copeptin) levels in ascites patients. The Non-responder group is considered to be in a state of relative vascular underfilling with an increase in BUN and copeptin, thus suggesting intravascular dehydration \u003csup\u003e11\u003c/sup\u003e. Furthermore, serum copeptin also correlated with multiple factors including renal function and CRP, resulting in copeptin was not only a biomarker of renal function. Although NGAL and L-FABP are useful markers than copeptin for acute-on-chronic liver failure \u003csup\u003e22\u003c/sup\u003e and acute kidney injury \u003csup\u003e23\u003c/sup\u003e, respectively, this study indicated that serum NGAL and L-FABP were not useful in assessing the efficacy of response to tolvaptan in LC patients with ascites.\u003c/p\u003e\n\u003cp\u003eSerum ZAG, it has been determined, is increased in acute kidney injury \u003csup\u003e24\u003c/sup\u003e and in minor kidney injury caused by normo-albuminuric diabetic kidney disease \u0026ndash; patients presenting with renal insufficiency, but no significant proteinuria \u003csup\u003e25\u003c/sup\u003e. On the other hand, serum cystatin C accurately reflects renal function, while ZAG reflects lipolysis and renal function. Serum ZAG has been expected as a biomarker for cachexia \u003csup\u003e26\u003c/sup\u003e. Indeed, in this study, ZAG correlated with body weight, BMI and CRP. Bellos also reported that body weight loss and elevated CRP were the predictors for Non-responders to tolvaptan \u003csup\u003e12\u003c/sup\u003e. We assumed that association of serum ZAG with multiple factors including renal function, cachexia (relating to body weight and BMI) and/or inflammation (relating to CRP) led to the result.\u003c/p\u003e\n\u003cp\u003eBased on the evidence outlined above, serum copeptin may reveal the underlying pathological condition of decreased osmotic pressure, intravascular dehydration and inflammation, whereas serum ZAG may reflect minor kidney injury, cachexia and inflammation, suggesting that copeptin and ZAG are independent predictors of patient response to tolvaptan.\u003c/p\u003e\n\u003cp\u003eAlthough many patients with LC are complicated by HCC, it is not known whether coexistent HCC linked to response to tolvaptan therapy. Recent large-scale post-marketing surveillance study (n=1111) reported that there was no difference in mean of weight reduction by tolvaptan treatment between patients with and without HCC (p=0.2248) \u003csup\u003e27\u003c/sup\u003e. Both the American and European clinical practice guidelines recommended high-dose diuretic treatment against massive ascites \u003csup\u003e15\u003c/sup\u003e. In contrast, the Japanese guideline recommended additional tolvaptan administration for massive ascites. Together, clinical trials involving a large number of patients are needed to determine the timing of tolvaptan initiation.\u003c/p\u003e\n\u003cp\u003eThis study has several limitations. This was a retrospective and single-center study with a small sample size and a short follow-up period. Therefore, the confidence intervals of the predictors for tolvaptan treatment of ascites were huge due to a small sample size. Further study using a larger cohort, especially many cirrhotic patients without HCC, is required to investigate the interaction of copeptin, ZAG, and BUN and the possible predictors of patient survival. In conclusion, serum BUN \u0026lt; 18.3 mg/dL, copeptin \u0026lt; 10.1 pmol/L and ZAG \u0026lt; 32.4 \u0026mu;g/ml appear to be good predictors of overall patient response to tolvaptan treatment.\u003c/p\u003e\n"},{"header":"Conclusions","content":"\u003cp\u003eSerum copeptin, ZAG and BUN levels may be used as novel biomarkers to determine overall response to tolvaptan in patients presenting with LC and ascites. Future study is required to develop a new clinical prediction model using serum copeptin, ZGA and BUN that would help clinicians determine the effectiveness of tolvaptan treatment.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eLC, liver cirrhosis; ZAG, zinc-\u0026alpha;2-glycoprotein; AVP, arginine vasopressin; NGAL, neutrophil gelatinase-associated lipocalin; L-FABP, liver-type fatty acid-binding protein; HCV, hepatitis C virus; BMI, Body mass index, PMI, Psoas muscle index; BUN, blood urea nitrogen; CRP, C-reactive protein; AFP, \u0026alpha;-fetoprotein; DCP, des-\u0026gamma;-carboxy prothrombin; ALBI, albumin-bilirubin; FIB-4, fibrosis index based on 4 factors; MELD, Model for end-stage liver disease; eGFR, estimated glomerular filtration rate; MDRD, Modification of Diet in Renal Disease; ROC, receiver operating characteristic\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eStatement of Ethics\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe study protocol was approved by the Clinical Research Ethics Review Committee of Mie University Hospital (approval no. H2019-190). This research comply with the guidelines for human studies and should include evidence that the research was conducted ethically in accordance with the World Medical Association Declaration of Helsinki. The subjects (or their parents or legal guardians) have given their written informed consent.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConflict of Interest Statement (\u003c/strong\u003eCompeting interests\u003cstrong\u003e)\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAuthors does not have any conflict of interests, except Motoh Iwasa received a lecture fee from Otsuka Pharmaceutical Co., Ltd, which manufactures tolvaptan.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent to publish; \u003c/strong\u003eAll authors agree to publish.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials; \u003c/strong\u003eDepartment of Gastroenterology and Hepatology, Mie University Graduate School of Medicine\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding Sources\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNo external financial support was received.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor\u0026rsquo;s contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eRS: statistical analysis, data interpretation and drafting the article; MI: study concept, design, data acquisition, data interpretation and drafting the article; AE: sample analyses, data interpretation and critical revision of the article for important intellectual content; MT: sample analyses; YT: sample collection; TS: data analysis; YT: critical revision of the article for important intellectual content; All authors: approval of the final version of the manuscript\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgement\u003c/strong\u003e; There was no acknowledgement.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eBolignano D, Cabassi A, Fiaccadori E, Ghigo E, Pasquali R, Peracino A, et al: Copeptin (CTproAVP), a new tool for understanding the role of vasopressin in pathophysiology. Clin Chem Lab Med. 2014;52(10):1447-1456.\u003c/li\u003e\n\u003cli\u003eMorgenthaler NG, Struck J, Alonso C, Bergmann A: Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin. Clin Chem. 2006;52(1):112-119.\u003c/li\u003e\n\u003cli\u003eKerbert AJC, Weil D, Verspaget HW, Mor\u0026eacute;no JP, Hoek BV, Cervoni JP, et al: Copeptin is an independent prognostic factor for transplant-free survival in cirrhosis. Liver Int. 2016;36(4):530-537.\u003c/li\u003e\n\u003cli\u003eSol\u0026agrave; E, Kerbert AJC, Verspaget HW, Moreira R, Pose E, Ruiz P, et al: Plasma copeptin as biomarker of disease progression and prognosis in cirrhosis. J Hepatol. 2016;65(5):914-920.\u003c/li\u003e\n\u003cli\u003eBouchara A, Yi D, Pastural M, Granjon S, Selag JC, Laville M, et al: Serum levels of the adipokine zinc-alpha2-glycoprotein (ZAG) predict mortality in hemodialysis patients. Kidney Int. 2018;94(5):983-992.\u003c/li\u003e\n\u003cli\u003eMishra J, Dent C, Tarabishi R, Mitsnefes MM, Ma Q, Kelly C, et al: Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet. 2005;365(9466):1231-1238.\u003c/li\u003e\n\u003cli\u003eMori K, Lee HT, Rapoport D, Drexler IR, Foster K, Yang J, et al : Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J Clin Invest. 2005;115(3):610-621.\u003c/li\u003e\n\u003cli\u003eIchikawa D, Kamijo-Ikemori A, Sugaya T, Ohata K, Hisamichi M, Hoshino S, et al: Utility of urinary tubular markers for monitoring chronic tubulointerstitial injury after ischemia-reperfusion. Nephrology (Carlton). 2018;23(4):308-316.\u003c/li\u003e\n\u003cli\u003eYoshikawa K, Iwasa M, Eguchi A, Kojima S, Yoshizawa N, Tempaku M, et al: Neutrophil gelatinase-associated lipocalin level is a prognostic factor for survival in rat and human chronic liver diseases. Hepatol Commun. 2017;1(9):946-956.\u003c/li\u003e\n\u003cli\u003eEguchi A, Hasegawa H, Iwasa M, Tamai Y, Ohata K, Oikawa T, et al: Serum Liver-Type Fatty Acid-Binding Protein Is a Possible Prognostic Factor in Human Chronic Liver Diseases From Chronic Hepatitis to Liver Cirrhosis and Hepatocellular Carcinoma. Hepatol Commun. 2019;3(6):825-837.\u003c/li\u003e\n\u003cli\u003eKawaratani H, Fukui H, Moriya K, Noguchi R, Namisaki T, Uejima M, et al: Predictive parameter of tolvaptan effectiveness in cirrhotic ascites. Hepatol Res. 2017;47(9):854-861.\u003c/li\u003e\n\u003cli\u003eBellos I, Kontzoglou K, Perrea DN: Predictors of tolvaptan short-term response in patients with refractory ascites: A meta-analysis. J Gastroenterol Hepatol. 2020;35(2):182-191.\u003c/li\u003e\n\u003cli\u003eAtsukawa M, Tsubota A, Takaguchi K, Toyoda H, Iwasa M, Ikegami T, et al: Analysis of factors associated with the prognosis of cirrhotic patients who were treated with tolvaptan for hepatic edema. J Gastroenterol Hepatol. 2020;35(7):1229-1237.\u003c/li\u003e\n\u003cli\u003eBellos I, Kontzoglou K, Psyrri A, Pergialiotis V: Tolvaptan Response Improves Overall Survival in Patients with Refractory Ascites: A Meta-Analysis. Dig Dis 2020;38(4):320-328.\u003c/li\u003e\n\u003cli\u003eFukui H, Saito H, Ueno Y, Uto H, Obara K, Sakaida I, et al. Evidence-based clinical practice guidelines for liver cirrhosis 2015. J Gastroenterol 2016;51(7):629-650.\u003c/li\u003e\n\u003cli\u003eHiramine Y, Uojima H, Nakanishi H, Hiramatsu A, Iwamoto T, Kimura M, et al. Response criteria of tolvaptan for the treatment of hepatic edema. J Gastroenterol. 2018;53(2):258-268.\u003c/li\u003e\n\u003cli\u003eJohnson PJ, Berhane S, Kagebayashi C, Satomura S, Teng M, Reeves HL, et al: Assessment of liver function in patients with hepatocellular carcinoma: a new evidence-based approach-the ALBI grade. J Clin Oncol. 2015;33(6):550-558.\u003c/li\u003e\n\u003cli\u003eSterling RK, Lissen E, Clumeck N, Sola R, Correa MC, Montaner J, et al: Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection. Hepatology. 2006;43(6):1317-1325.\u003c/li\u003e\n\u003cli\u003eMoller S, Bendtsen F: The pathophysiology of arterial vasodilatation and hyperdynamic circulation in cirrhosis. Liver Int. 2018;38(4):570-580.\u003c/li\u003e\n\u003cli\u003eSchrier RW, Arroyo V, Bernardi M, Epstein M, Henriksen JH, Rodes J: Peripheral arterial vasodilation hypothesis: a proposal for the initiation of renal sodium and water retention in cirrhosis. Hepatology. 1988;8(5):1151-1157.\u003c/li\u003e\n\u003cli\u003eP\u0026eacute;rez-Ayuso RM, Arroyo V, Camps J, Rimola A, Gaya J, Costa J, et al: Evidence that renal prostaglandins are involved in renal water metabolism in cirrhosis. Kidney Int. 1984;26(1):72-80.\u003c/li\u003e\n\u003cli\u003eBelcher JM, Parikh CR, Garcia-Tsao G. Acute kidney injury in patients with cirrhosis: perils and promise. Clin Gastroenterol Hepatol. 2013;11(12):1550-1558.\u003c/li\u003e\n\u003cli\u003eAllegretti AS, Sol\u0026agrave; E, Gin\u0026egrave;s P. Clinical application of kidney biomarkers in cirrhosis. Am J Kidney Dis. 2020 Jul 1;S0272-6386(20)30691-0.\u003c/li\u003e\n\u003cli\u003eSorensen-Zender I, Beneke J, Schmidt BM, Menne J, Haller H, Schmitt R. Zinc-alpha2-glycoprotein in patients with acute and chronic kidney disease. BMC Nephrol. 2013;14:145.\u003c/li\u003e\n\u003cli\u003eLim SC, Liying DQ, Toy WC, Wong M, Yeoh LY, Tan C,et al: Adipocytokine zinc alpha2 glycoprotein (ZAG) as a novel urinary biomarker for normo-albuminuric diabetic nephropathy. Diabet Med. 2012;29(7):945-949.\u003c/li\u003e\n\u003cli\u003eBing C, Trayhurn P: New insights into adipose tissue atrophy in cancer cachexia. Proc Nutr Soc 2009;68:385-392.\u003c/li\u003e\n\u003cli\u003eSakaida I, Terai S, Kurosaki M, Okada M, Hirano T, Fukuta Y. Real-world effectiveness and safety of tolvaptan in liver cirrhosis patients with hepatic edema: results from a post-marketing surveillance study (START study). J Gastroenterol 2020;55(8):800-810.\u003c/li\u003e\n\u003c/ol\u003e\n"},{"header":"Tables","content":"\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eTable 1. Characteristics of 113 liver cirrhotic patients.\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cdiv align=\"center\" style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\n \u003ctable style=\"width: 566.85pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" style=\"width: 195.8pt;border-color: windowtext white;border-style: solid;border-width: 1pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Century\",serif;line-height:300%;'\u003e\u003cspan style='font-size:12px;line-height:300%;font-family:\"Times New Roman\",serif;'\u003eParameters\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.75pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eAll\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eWithout ascites\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 141.75pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eWith ascites\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 70.65pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: none;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 74.75pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eNon-treatment\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width: 135.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;text-indent:4.5pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eTreatment\u003cem\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;p\u003c/em\u003e\u003csup\u003e\u0026dagger;\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 74.75pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003en = 113\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003en = 46\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003en = 22\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 64.7pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003en = 45\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 70.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eAge (years)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e68.0\u003c/span\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;(60.0-75.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e66.5\u0026nbsp;\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e(58.0-72.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e74.0\u0026nbsp;\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e(66.3-80.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e68.0 (61.0-76.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.1117\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eGender, Male : Female\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e69 : 44\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e29 : 17\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e14 : 8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e26 : 19\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.6939\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eBodyweight (kg)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e58.1 (51.3-66.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e62.3 (51.3-72.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e57.0 (53.4-61.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e56.6 (51.0-63.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.7620\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eBody mass index (kg/m\u003csup\u003e2\u003c/sup\u003e)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e23.6 (20.8-25.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e24.0 (22.5-25.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e22.3 (20.1-25.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e22.1 (19.5-24.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.7010\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePsoas muscle index (cm\u003csup\u003e2\u003c/sup\u003e/m\u003csup\u003e2\u003c/sup\u003e)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e5.6 (4.7-7.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e6.1 (4.7-7.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e5.6 (4.8-6.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e5.2 (4.2-6.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.2651\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eHCV/HBV/HCV+AL/AL/\u003cspan style=\"color:black;\"\u003eNASH\u003c/span\u003e/others\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e56/7/4/23/13/10\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e28/2/0/10/2/4\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e11/0/1/3/4/3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e17/4/3/10/7/4\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003epresence of HCC, yes: no\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e61 : 52\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e23 : 23\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e10 : 12\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e28 : 17\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.6045\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eRatio of using diuretic drugs (%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e26\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e45\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eDose of diuretic drugs (n)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:red;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:red;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;Tolvaptan (0mg/3.75mg/7.5mg)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e68 / 37 / 8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e46 / 0 / 0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e22 / 0 / 0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0 / 37 / 8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;Furosemide (0mg/10mg/20mg/40mg/80mg)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e62/4/28/14/5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e40/0/4/2/0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e16/1/4/0/1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e6/3/20/12/4\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026lt;0.0001\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;text-indent:4.5pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eSpironolactone (0mg/25mg/50mg/100mg)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e55 / 26 / 28 / 4\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e38 / 4 / 3 / 1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e14 / 4 / 3 / 1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e3 / 18 / 22 / 2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026lt;0.0001\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eGrade of ascites (1 / 2 / 3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e37 / 22/ 8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0 / 0 / 0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e17 / 2 / 3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e20 / 20 / 5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e-\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eAST (U/L)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e45.0 (31.0-70.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e37.0 (28.3-54.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e35.5 (28.0-62.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e55.0 (42.0-87.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e0.0014\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eALT (U/L)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e29.0 (17.0-41.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e28.0 (17.0-41.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e29.5 (15.0-34.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e29.0 (23.0-42.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.2421\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eAlbumin (g/dL)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e3.2 (2.8-3.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e3.6 (3.3-4.1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e3.3 (3.0-3.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e2.9 (2.6-3.1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e0.0010\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eTotal Bilirubin (mg/dL)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.2 (0.7-1.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.1 (0.7-1.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.8 (0.7-1.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.5 (0.8-2.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e0.0210\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eProthrombin time (%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e72.0 (60.9-82.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e75.6 (64.1-84.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e74.2 (61.5-85.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e67.4 (55.1-78.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.1297\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChild-Pugh score\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e7.0 (6.0-9.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e5.5 (5.0-6.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e7.5 (6.3-9.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e8.0 (8.0-10.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e0.0083\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eALBI score\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e-1.9 (-2.4- -1.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e-2.4 (-2.6- -1.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e-2.0 (-2.7- -1.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e-1.5 (-1.8- -1.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e0.0004\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eFIB4-index\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e6.3 (3.8-9.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e5.2 (3.5-7.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e5.0 (3.7-8.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e8.0 (5.5-10.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e0.0343\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eMELD score\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e16.0 (14.6-18.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e15.0 (14.0-16.1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e16.5 (15.8-20.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e16.9 (15.0-19.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.6643\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eMELD-Na score\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e18.3 (15.5-21.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e15.6 (13.5-17.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e17.6 (16.5-21.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e20.3 (18.4-23.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.0557\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eCreatinine (mg/dL)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.8 (0.6-1.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.7 (0.6-0.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.9 (0.8-1.1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.8 (0.7-1.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.2143\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eBUN (mg/dL)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e15.5 (11.7-22.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e14.0 (10.0-18.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e18.0 (13.5-27.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e18.5 (13.0-25.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.6594\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eeGFR (mL/min/1.73m\u003csup\u003e2\u003c/sup\u003e)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e69.0 (59.0-104.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e75.1 (59.3-93.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e58.8 (34.4-74.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e61.1 (46.7-87.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.4999\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eGFR (MDRD-6)\u003c/span\u003e\u003cspan style=\"font-size:12px;\"\u003e\u0026nbsp;(\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003emL/min)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e84.3 (70.4-126.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e99.6 (80.4-128.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e75.5 (53.0-95.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e77.2 (54.0-95.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.5887\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eSerum sodium (mEq/L)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e138 (134-140)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e140 (139-141)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e138 (136-139)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e134 (131-138)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e0.00\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e43\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eCRP (mg/dL)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.3 (0.1-1.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.1 (0.0-0.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.05pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.2 (0.1-1.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 91.35pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.2 (0.4-3.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026lt;0.0001\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eCopeptin (pmol/L)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e6.6 (3.6-14.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e4.2 (2.6-6.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:84.85pt;border-top:none;border-left: none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e8.0 (5.2-15.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 83.55pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e10.7 (5.4-19.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.5002\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eZAG (\u0026mu;g/mL)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e29.2 (24.3-37.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e27.4 (22.5-32.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:84.85pt;border-top:none;border-left: none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e37.9 (26.9-45.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 83.55pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e32.1 (24.7-41.1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.1797\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eNGAL (ng/mL)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e61.0 (30.1-104.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e30.3 (18.4-53.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:84.85pt;border-top:none;border-left: none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e88.9 (43.9-114.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 83.55pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e82.9 (54.8-149.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.6595\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eCystatin C (mg/dL)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.1 (0.9-1.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.0 (0.8-1.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:84.85pt;border-top:none;border-left: none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.2 (1.0-1.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 83.55pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.1 (0.9-1.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.2854\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.8pt;border-top: none;border-left: 1pt solid white;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eL-FABP (ng/mL)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:74.75pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e8.1 (3.8-13.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 83.9pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e5.3 (2.2-13.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:84.85pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e8.4 (3.8-10.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 83.55pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;background: white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e9.7 (5.5-19.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:44.0pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.2119\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003csup\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026dagger;\u003c/span\u003e\u003c/sup\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;Mann\u0026ndash;Whitney \u003cem\u003eU\u003c/em\u003e test (Non-treatment vs. Treatment). HCV, hepatitis C virus; HBV, hepatitis B virus; AL, alcohol; NASH, nonalcoholic steatohepatitis; HCC, hepatocellular carcinoma; AST,\u003c/span\u003e\u003cspan style=\"font-size:12px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003easpartate aminotransferase; ALT,\u003c/span\u003e\u003cspan style=\"font-size:12px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ealanine aminotransferase; ALBI, albumin-bilirubin; FIB4-index, fibrosis-4; MELD, Model for End-Stage Liver Disease; BUN, blood urea nitrogen; eGFR, estimated glomerular filtration rate; MDRD-6, the 6-variable Modification of Diet in Renal Disease; CRP, C-reactive protein; ZAG, zinc-\u0026alpha;2-glycoprotein; NGAL, neutrophil gelatinase-associated lipocalin; L-FABP, Liver-type fatty acid\u0026ndash;binding protein. All data are expressed as median (first quartile-third quartile).\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u003cbr\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eTable 2. Correlation between serum copeptin, ZAG, cystatin C, NGAL, L-FABP levels and clinical parameters in 113 liver cirrhotic patients.\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003ctable style=\"width: 5.7e+2pt;margin-left:-51.2pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 85.1pt;border-color: windowtext white;border-style: solid;border-width: 1pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eParameter\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 96.35pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eCopeptin\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 96.15pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eZAG\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 98.1pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eCystatin C\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 99.2pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eNGAL\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 99.25pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eL-FABP\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 48.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003er\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 47.55pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003ep\u003c/span\u003e\u003c/em\u003e\u003csup\u003e\u003cspan style='font-size:12px;font-family:\"MS Mincho\";'\u003e※\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 47.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003er\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003ep\u003c/span\u003e\u003c/em\u003e\u003csup\u003e\u003cspan style='font-size:12px;font-family:\"MS Mincho\";'\u003e※\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003er\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003ep\u003c/span\u003e\u003c/em\u003e\u003csup\u003e\u003cspan style='font-size:12px;font-family:\"MS Mincho\";'\u003e※\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003er\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003ep\u003c/span\u003e\u003c/em\u003e\u003csup\u003e\u003cspan style='font-size:12px;font-family:\"MS Mincho\";'\u003e※\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003er\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003ep\u003c/span\u003e\u003c/em\u003e\u003csup\u003e\u003cspan style='font-size:12px;font-family:\"MS Mincho\";'\u003e※\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.1pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eAge\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.8pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e-0.0127\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 47.55pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.8930\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 47.5pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.1691\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.65pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.0734\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.45pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.2202\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.65pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e0.0191\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.1902\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e0.0436\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp 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49.65pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.1pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChild-Pugh score\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.8pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid 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style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e0.0227\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.1pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eALBI score\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.8pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.3366\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 47.55pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e0.0003\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 47.5pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e-0.0921\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.65pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.3322\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.45pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.0656\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.65pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.4901\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.3750\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026lt; 0.0001\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.2078\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.65pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e0.0272\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.1pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eMELD score\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.8pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.3057\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 47.55pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e0.0010\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 47.5pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.3338\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.65pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e0.0003\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.45pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.5595\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.65pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026lt; 0.0001\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.4498\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026lt; 0.0001\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.2839\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.65pt;border-top: none;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e0.0024\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.1pt;border-top: none;border-left: 1pt solid white;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eMELD-Na score\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.3187\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 47.55pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e0.0008\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 47.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.3135\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e0.0010\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.4342\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026lt; 0.0001\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.5188\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026lt; 0.0001\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.3450\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e0.0003\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003csup\u003e\u003cspan style='font-size:12px;font-family:\"MS Mincho\";color:white;'\u003e※\u003c/span\u003e\u003c/sup\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eSpearman\u0026#39;s rank correlation coefficient. BMI, body mass index; PMI, psoas muscle index; AST,\u003c/span\u003e\u003cspan style=\"font-size:12px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003easpartate aminotransferase; ALT,\u003c/span\u003e\u003cspan style=\"font-size:12px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ealanine aminotransferase; BUN, blood urea nitrogen; eGFR, estimated glomerular filtration rate; MDRD-6, the 6-variable Modification of Diet in Renal Disease; CRP, C-reactive protein; ZAG, zinc-\u0026alpha;2-glycoprotein; NGAL, neutrophil gelatinase-associated lipocalin; L-FABP, Liver-type fatty acid\u0026ndash;binding protein; ALBI, albumin-bilirubin; MELD, Model for End-Stage Liver Disease.\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u003cbr\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;line-height:200%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eTable 3. Characteristics of patients treated with Tolvaptan.\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003ctable style=\"width: 3.8e+2pt;margin-left: -.15pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 175.2pt;border-color: windowtext white;border-style: solid;border-width: 1pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Century\",serif;line-height:300%;'\u003e\u003cspan style='font-size:12px;line-height:300%;font-family:\"Times New Roman\",serif;'\u003eParameters\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 80pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eResponders\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eNon-responders\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003ep\u003c/span\u003e\u003c/em\u003e\u003csup\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026dagger;\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 80pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003en = 19\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.95pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003en = 19\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eAge (years)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e65.0\u003c/span\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;(60.5-74.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e68.0\u003c/span\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;(58.0-73.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.7589\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eGender, Male : Female\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e13 : 6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e11 : 8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.5795\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eBodyweight (kg)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e61.2 (55.6-64.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e57.0 (50.9-63.1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.4229\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eBody mass index (kg/m\u003csup\u003e2\u003c/sup\u003e)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e21.9 (19.3-24.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e22.5 (19.2-24.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.8315\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePsoas muscle index (cm\u003csup\u003e2\u003c/sup\u003e/m\u003csup\u003e2\u003c/sup\u003e)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e5.7 (4.5-7.1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e5.3 (4.6-5.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.5534\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eHCV/HBV/HCV+AL/AL/NASH/others\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e7/0/2/6/2/2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e5/4/1/4/4/1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003epresence of HCC, yes: no\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e11 : 8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e12 : 7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.7862\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eDose of diuretic drugs\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;Tolvaptan (3.75 mg/7.5 mg)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e15 / 4\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e17 / 2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.6976\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;Furosemide (mg)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e20 (5-35)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e20 (20-40)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.8217\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;text-indent:4.5pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eSpironolactone (mg)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e50 (25-50)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e25 (25-50)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.2548\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eAlbumin (g/dL)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e2.9 (2.6-3.1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e2.8 (2.7-3.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.8490\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eTotal Bilirubin (mg/dL)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.8 (1.2-3.1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.4 (0.8-2.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.1361\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChild-Pugh score\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e8.0 (8.0-10.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e8.0 (7.5-10.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.3679\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eALBI score\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e-1.4 (-1.8- -1.1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e-1.5 (-1.8 - -1.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.7371\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eFIB4-index\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e7.8 (6.3-10.1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e8.3 (5.0-10.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.9534\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eMELD score\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e16.6 (15.0-19.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e17.4 (15.8-20.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.3655\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eMELD-Na score\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e20.3 (18.9-22.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e21.3 (18.0-23.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.9302\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eCreatinine (mg/dL)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.8 (0.6-0.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.9 (0.7-1.1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.2932\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eBUN (mg/dL)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e13.0 (10.0-19.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e23.0 (18.8-27.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e0.0014\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eeGFR (mL/min/1.73m\u003csup\u003e2\u003c/sup\u003e)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e69.4 (50.2-81.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e58.2 (45.4-76.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.2093\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eGFR (MDRD-6) (mL/min)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e82.8 (60.1-102.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e60.2 (51.8-88.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.0904\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eSerum sodium (mEq/L)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e134 (132-137)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e135 (132-139)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.2909\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eCRP (mg/dL)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.2 (0.4-2.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.9 (0.4-3.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.5018\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eCopeptin (pmol/L)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e6.6 (4.0-14.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e14.0 (9.0-27.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e0.0265\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eZAG (\u0026mu;g/mL)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e27.4 (23.1-33.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e37.4 (32.8-44.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e0.0142\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eNGAL (ng/mL)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e95.1 (59.5-162.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e82.9 (61.2-140.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.0000\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eCystatin C (mg/dL)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.1 (0.9-1.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.1 (0.8-1.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.9534\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eL-FABP (ng/mL)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e8.5 (4.4-17.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e11.5 (8.1-17.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.2429\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eAFP (ng/mL)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e9 (5-335)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e8 (3-67)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid white 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.4362\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 175.2pt;border-top: none;border-left: 1pt solid white;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eDCP (mAU/mL)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.0pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e498 (39-8039)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e2816 (157-9950)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid white 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.5065\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003csup\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026dagger;\u003c/span\u003e\u003c/sup\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;Mann\u0026ndash;Whitney \u003cem\u003eU\u003c/em\u003e test, HCV, hepatitis C virus; HBV, hepatitis B virus; AL, alcohol; NASH, nonalcoholic steatohepatitis; HCC, hepatocellular carcinoma; ALBI, albumin-bilirubin; FIB4-index, fibrosis-4; MELD, Model for End-Stage Liver Disease; BUN, blood urea nitrogen; eGFR, estimated glomerular filtration rate; MDRD-6, the 6-variable Modification of Diet in Renal Disease; CRP, C-reactive protein; ZAG, zinc-\u0026alpha;2-glycoprotein; NGAL,\u003c/span\u003e\u003cspan style=\"font-size:12px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eneutrophil gelatinase-associated lipocalin; L-FABP, Liver-type fatty acid\u0026ndash;binding protein; AFP,\u003c/span\u003e\u003cspan style=\"font-size:12px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026alpha;-fetoprotein; DCP, Des-\u0026gamma;-carboxy prothrombin. Responders were defined as decompensated liver cirrhosis patients in whom tolvaptan was an effective treatment for ascites. All data are expressed as median (first quartile-third quartile).\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u003cbr\u003e\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;line-height:200%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eTable 4. Predictors contributing to the effect of Tolvaptan in the treatment for ascites\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003ctable style=\"width: 5.3e+2pt;margin-left:-28.3pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 47.4pt;border-width: 1pt;border-style: solid;border-color: windowtext white white;border-image: initial;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePredictors\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ecutoff\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 49.6pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eROCAUC\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.65pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eSensitivity\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid white;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eSpecificity\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 148.8pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eUnivariate analysis\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 141.75pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eMultivariate analysis\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 47.4pt;border-top: none;border-left: 1pt solid white;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eOR\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e95%CI\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003ep\u003csup\u003e\u0026sect;\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eOR\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e95%CI\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003ep\u003csup\u003e\u0026sect;\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 47.4pt;border-right: 1pt solid white;border-bottom: 1pt solid white;border-left: 1pt solid white;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp 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\u0026rarr; 4.69\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.7399\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid white;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:white;'\u003eROCAUC, receiver\u0026nbsp;\u003c/span\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eoperating characteristic area under the curve.\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ep\u003csup\u003e\u0026sect;\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e; Logistic regression analysis; OR, odds ratio; 95%CI, 95%\u0026nbsp;\u003c/span\u003e\u003ca href=\"https://lsd-project.jp/weblsd/c/begin/confidence%20interval\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003econfidence interval\u003c/span\u003e\u003c/a\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eBUN, blood urea nitrogen; ZAG, zinc-\u0026alpha;2-glycoprotein; HCC, hepatocellular carcinoma.\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;line-height:200%;'\u003e\u003cspan style='font-size:12px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;line-height:200%;'\u003e\u003cspan style='font-size:12px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;line-height:200%;'\u003e\u003cspan style='font-size:12px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;line-height:200%;'\u003e\u003cspan style='font-size:12px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Century\",serif;'\u003e\u003cspan style=\"font-size:12px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"copeptin, zinc-α2-glycoprotein (ZAG), tolvaptan, liver cirrhosis, ascites","lastPublishedDoi":"10.21203/rs.3.rs-52252/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-52252/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eBackground: The efficacy of tolvaptan, an orally active vasopressin V2-receptor antagonist, has recently been reported in patients with massive ascites unresponsive to conventional diuretics. However, the effect of tolvaptan varies among patients. Recently, the prognostic role of tolvaptan response in decompensated liver cirrhosis (LC) has started to attract more attention. Our aim is to elucidate predictive factors using serum copeptin (vasopressin precursor), zinc-α2-glycoprotein (ZAG), cystatin C (renal biomarker), neutrophil gelatinase-associated lipocalin (NGAL) and liver-type fatty acid-binding protein (L-FABP) that portend a good response to tolvaptan in LC patients with ascites.\u003c/p\u003e\u003cp\u003eMethods: We enrolled 113 LC patients and divided into tolvaptan treatment group and non-treatment group. Tolvaptan (3.75 or 7.5 mg/day) was administrated to 38 LC patients with ascites and a follow-up assessment occurred after a 7-day tolvaptan treatment regimen. \u003c/p\u003e\u003cp\u003eResults: We revealed predictive ability for kidney and/or liver damage in serum copeptin, ZAG, cystatin C, NGAL and L-FABP levels in all patients. Post 7-day tolvaptan treatment, 19 patients lost more than 1.5 kg of their body weight (Responders), while 19 patients did not change their body weight significantly (Non-responders). Basal blood urea nitrogen (BUN) (p=0.0014), serum copeptin (p=0.0265) and serum ZAG levels (p=0.0142) were significantly higher in the Non-responders. BUN (odds ratio 7.43, p=0.0306), copeptin (odds ratio 9.12, p=0.0136) and ZAG (odds ratio 7.43, p=0.0306) were determined to be predictive factors of drug responsiveness using multivariate logistic regression analysis.\u003c/p\u003e\u003cp\u003eConclusion: Serum BUN, copeptin and ZAG levels predict patient response to tolvaptan even when measured prior to treatment.\u0026nbsp;\u003c/p\u003e","manuscriptTitle":"Serum copeptin and zinc-α2-glycoprotein levels are novel biomarkers of tolvaptan treatment in decompensated cirrhotic patients with ascites.","msid":"","msnumber":"","nonDraftVersions":[{"code":2,"date":"2020-10-06 18:48:49","doi":"10.21203/rs.3.rs-52252/v2","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2020-08-12 15:36:37","doi":"10.21203/rs.3.rs-52252/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"5a97a1f9-ecd3-4d5d-935a-29fc47b7adc5","owner":[],"postedDate":"October 6th, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":708498,"name":"Gastroenterology \u0026 Hepatology"}],"tags":[],"updatedAt":"2021-10-31T22:54:15+00:00","versionOfRecord":{"articleIdentity":"rs-52252","link":"https://doi.org/10.2169/internalmedicine.7291-21","journal":{"identity":"internal-medicine","isVorOnly":true,"title":"Internal Medicine"},"publishedOn":"2021-11-01 22:54:15","publishedOnDateReadable":"November 1st, 2021"},"versionCreatedAt":"2020-10-06 18:48:49","video":"","vorDoi":"10.2169/internalmedicine.7291-21","vorDoiUrl":"https://doi.org/10.2169/internalmedicine.7291-21","workflowStages":[]},"version":"v2","identity":"rs-52252","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-52252","identity":"rs-52252","version":["v2"]},"buildId":"-HB7Z8yhvgn0wM9Nzuekk","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}