Isosorbide mononitrate induces increased cervical expression of cyclooxygenase-2, but not of cyclooxygenase-1, at term

Maria Bullarbo, M Bullarbo, Anders Norström, A Norström, B Andersch, E Ekerhovd, Erling Ekerhovd
European Journal of Obstetrics & Gynecology and Reproductive Biology · 2006 · vol. 130(2) , pp. 160–164 · doi:10.1016/j.ejogrb.2006.01.021 · PMID:16675095 · W1995513619
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Vaginal isosorbide mononitrate increases cervical cyclooxygenase-2 expression without affecting cyclooxygenase-1 in women at term, suggesting a role for nitric oxide in prostaglandin synthesis during cervical ripening.

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Abstract

OBJECTIVE: Prostaglandin and nitric oxide (NO) are both known to be involved in cervical ripening at term. The aim of the study was to investigate if NO has an effect on cervical expression of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), the two main isoenzymes involved in prostaglandin synthesis, and to localize these enzymes within the cervix. STUDY DESIGN: Women with an unripe cervix scheduled for elective caesarean section at term were randomly selected to receive vaginally either the NO donor isosorbide mononitrate (IMN) or placebo 4h before surgery. At the operating theatre, cervical tissue specimens were obtained for immunoblotting and immunohistochemistry. RESULTS: Increased expression of COX-2 was found in specimens exposed to IMN compared to specimens obtained from women in the placebo group. There was no difference in the expression of COX-1. Immunohistochemistry revealed similar localization of the two enzymes in treated and untreated women. CONCLUSIONS: Vaginal administration of IMN induces increased cervical expression of COX-2, but not of COX-1. This pathway may be of importance in the process of cervical ripening at term.

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MeSH descriptors

Cervical Ripening Cervix Uteri Cyclooxygenase 1 Cyclooxygenase 2 Nitric Oxide Biopsy Cervical Ripening Cervix Uteri Cervix Uteri Cyclooxygenase 1 Cyclooxygenase 1 Cyclooxygenase 2 Cyclooxygenase 2 Epithelial Cells Epithelial Cells Epithelial Cells Female Humans Immunohistochemistry Isosorbide Dinitrate

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