Influence of mifepristone on IL-6 and TNF level in patients with endometriosis before and after undergoing surgery treatment

Objective: To investigate the influence of mifepristone on IL-6 and TNF level in patients with endometriosis after undergoing surgery.Methods:A total of 108 patients with endometriosis that underwent treatment were randomly divided into treatment group and control group with 54 cases in each group.Fifty-two healthy volunteers were also enrolled as normal control group.IL-6 and TNF level before undergoing surgery,3 days and 12 weeks after undergoing treatment were detected with ELISA and compared among the three groups.Results:Before undergoing surgery,IL-6 and TNF levels in the study group(was given mifepristone) and control group were significant higher than that in the normal control group(P all 0.05).But after undergoing surgery,no significant difference in IL-6 and TNF levels were observed.Three days and 12 weeks after undergoing surgery,IL-6 and TNF levels were significantly different from that before the surgery(P0.01).After mifepristone treatment for 12 weeks,the IL-6 and TNF levels in treatment group was significant lower than that in the control group,correlation between IL-6 and TNF levels were observed.Conclusions:Drug treatment is necessary for patients undergoing Ems,IL-6 and TNF-EM levels can be used for monitoring treatment efficacy of Ems,and prediction of early recurrence.