Why disulfiram is not a panacea?

Two recent studies in Nature and Nature Immunology suggest that an old anti-alcoholism drug disulfiram could treat covid-19 and sepsis, respectively [1-2]. In fact, disulfiram is highly reactive compound (creating both S-S bonds with thiols and chelates with metals) which almost does not exist in the body early after ingestion (the anti-alcoholism effect is caused by its metabolites). [3]