PYRAZINE DERIVATIVES AS MODULATORS OF TYROSINE KINASES

KUO GEE HONG, CONNOLLY PETER, PROUTY CATHERINE, DEANGELIS ALAN, WANG AIHUA, JOLLIFFE LINDA, MIDDLETON STEVE, EMANUEL STUART
2002
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Abstract

The present invention provides pyrazine derivatives that inhibit tyrosine kinase activity. Certain pyrazine derivatives are selective inhibitors of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. The present invention also provides pharmaceutical formulations containing the pyrazine derivatives and methods of use of these formulations as anti-tumor agents and to treat solid-tumor cancers, angiogenesis, diabetic retinopathy, rheumatoid arthritis, endometriosis and psoriasis.

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europepmc
last seen: 2026-07-07T06:07:59.301721+00:00