Study on the relationship between endometriosis and N-acetyl transferase 2 genetic polymorphism

Objective:To assess the possible association between gene mutation of N-acetyltransferase 2 and the susceptibility to endometriosis(EM).Methods:The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to detect NAT2 genetic genotype from the Hans (102 controls and 94 cases) in Tangshan Hebei province.Results:The distribution of acetylation genotype in cases were significantly different from those controls, and the degree of slow acetylation in cases was higher than in controls. Similarly, significant difference was observed in the distribution of slow acetylation genotype in phases three and four EMs compared with controls, but there was no difference between one and two EMs and controls.The frequency of slow acetylation showed a significant difference between adenomyosis group and controls, with an odds ratio of 20.44.Conclusion:An association is found between NAT2 slow acetylation genotype and endometriosis in the Hans population in Tangshan.