Pathological changes induced in the uterus of mice with the prolonged administration of progesterone and 19-nor-contraceptives

A Lipschutz, R Iglesias, V I Panasevich, S Salinas
British journal of cancer · 1967 · doi:10.1038/bjc.1967.15 · PMID:6024507 · PMC2008099
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-12 ⓘ

This study investigated uterine pathological changes in mice following prolonged administration of progesterone and 19-nor-contraceptives.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-12 · read from full text ⓘ

The paper investigated pathological changes in mouse uteruses following prolonged administration of progesterone and 19-nor contraceptives, using an in vivo experimental design to assess tissue alterations induced by these hormones. It reports that extended exposure leads to uterine pathological changes, attributable to the hormonal treatments, with findings described at the level of tissue pathology. A major limitation is that the study uses an animal model and focuses on drug-induced uterine effects rather than a disease process in humans. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 24 print issues and online access 251,40 € per year only 10,48 € per issue Buy this article - Purchase on SpringerLink - Instant access to the full article PDF. 39,95 € Prices may be subject to local taxes which are calculated during checkout Rights and permissions About this article Cite this article Lipschutz, A., Iglesias, R., Panasevich, V. et al. Pathological changes induced in the uterus of mice with the prolonged administration of progesterone and 19-nor-contraceptives.. Br J Cancer 21, 160–165 (1967). https://doi.org/10.1038/bjc.1967.15 Issue date: DOI: https://doi.org/10.1038/bjc.1967.15 This article is cited by - Murine Models and Research Progress on Dysmenorrhea Reproductive Sciences (2023) - Toxicology and pathology of female reproductive tract Cell Biology and Toxicology (2013)

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Condition tags

endometriosis

MeSH descriptors

Contraceptives, Oral Endometriosis Norethindrone Norethynodrel Progesterone Sarcoma Uterine Neoplasms Animals Contraceptives, Oral Endometriosis Endometriosis Female Mice Sarcoma Uterine Neoplasms Uterine Neoplasms

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europepmc
last seen: 2026-06-13T06:22:48.782012+00:00
pubmed
last seen: 2026-05-14T05:59:28.133692+00:00
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