CHARACTERISTICS OF HEMOSTASIS INDICATORS AND INFLAMMATION MARKERS IN WOMEN OF REPRODUCTIVE AGE WITH ADENOMYOSIS IN POST-COVID PERIOD
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Abstract
Odesa National Medical University, Odesa, Ukraine Introduction. In adenomyosis, microcirculatory disorders have been proven to characterize a chronic immunoinflammatory process in the endometrium and myometrium. These processes are especially severe in the setting of a viral load, thus the issue of the course of adenomyosis after COVID-19 has become relevant. The pathogenicity of the COVID-19 virus is due to its tropism to the epithelium of endothelial cells, which is realized in endothelial damage: the latter loses antithrombogenic properties, vascular wall permeability increases, and blood procoagulant properties and the synthesis of proinflammatory cytokines raise. Against the background of the inflammatory process in the endothelium, the blood coagulation cascade is initiated. The aim of the study was to investigate and compare the levels of blood coagulation system parameters and markers of inflammatory processes in women with adenomyosis in the post-COVID period during 3, 6, and 12 months after COVID-19. Materials and methods. The study included 180 women of reproductive age, including 60 apparently healthy women (group A), including 30 women with COVID-19 (group A2), 120 women with adenomyosis who had COVID-19, including 60 with adenomyosis of I–II severity level (group B), and 60 with adenomyosis of III–IV severity level (group C). Blood coagulation parameters (platelets, PT, APTT, INR, fibrinogen, D-dimer) and inflammatory markers (CRP, ferritin, procalcitonin) were determined. Results and discussion. The data obtained indicated the presence of hypercoagulability in women with COVID-19 (group A2), and more pronounced signs of hypercoagulation were determined in women with adenomyosis (groups B and C). Identical dynamics was observed in the determination of inflammatory markers between groups A2, B and C, which confirms the inflammatory process in tissues, including uterine tissue, which is also confirmed by clinical symptoms of adenomyosis in the post-COVID period.
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ХАРАКТЕРИСТИКА ПОКАЗНИКІВ ГЕМОСТАЗУ І МАРКЕРІВ ЗАПАЛЕННЯ У ЖІНОК РЕПРОДУКТИВНОГО ВІКУ З АДЕНОМІОЗОМ У ПОСТКОВІДНОМУ ПЕРІОДІ
DOI:
https://doi.org/10.32782/2226-2008-2024-3-9Ключові слова:
аденоміоз, постковідний період, гемостаз, маркери запаленняАнотація
Метою дослідження було визначення та порівняння рівнів показників системи згортання крові та маркерів запальних процесів у жінок, хворих на аденоміоз (Аз), у постковідному періоді після перенесеного COVID-19. Обстежено 180 жінок репродуктивного віку: 60 практично здорових жінок (група А), серед яких 30 жінок, що перехворіли на COVID-19 (група А2); 120 жінок, обтяжених аденоміозом, що перехворіли на COVID-19, з них: 60 – Аз І–ІІ ступенів тяжкості (група В) та 60 – Аз ІІІ–ІV ступенів тяжкості (група С). Отримані дані свідчили про наявність гіперкоагуляції у жінок, що перенесли захворювання COVID-19 та більш виражені ознаки гіперкоагуляції визначались у жінок, обтяжених Аз у постковідному періоді. Ідентична динаміка спостерігалась з визначенням маркерів запалення між групами, що підтверджує запальний процес у тканині матки.
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