Expressions of CA125 and CA19-9 in tissues of patients with endometriosis and their significances

Objective To investigate the expressions of CA125 and CA19-9 in endometriosis and the relationship with the serum values of CA125 and CA19-9. Methods Serum CA125 and CA19-9 levels were measured by using the magnetic separated enzyme linked immunosorbent assay respectively in 20 patients with sendometriosis. Forty paraffin samples of endometriosis(20 ectopic endometria and 20 endometria)were examined by immunohistochemical staining method to detect the expressions of CA125 and CA19-9. Results CA125 and CA19-9 were mainly expressed in the cytoplasm of glandular epithelial cells. The positive expression rates of CA125 in ectopic endometrium and endometrium were 90.0% and 25.0%, respectively;The expression rates of CA19-9 in ectopic endometrium and endometrium were 85.0% and 10.0%, respectively. The mean serum values of CA19-9 and CA125(U·mL~ -1)in 6 patients with stage Ⅰ and Ⅱ endometriosis were (29.64±10.24) and (25.85±9.45),respectively; the positive rates were 16.7% and 33.3%,respectively. The mean serum value of CA19-9 and CA125 (U·mL~ -1) in 14 patients with stage Ⅲ and Ⅳ endometriosis were (46.54±14.29 ) and (58.02±20.11), respectively;the positive rates were 42.8% and 71.4%, respectively. The expression of CA19-9 in ectopic endometrium was correlated to the serum value of CA19-9 (r s=0.36,P0.05), but not CA125 (r s=0.12,P0.05). Conclusion The CA125 and CA19-9 proteins express highly in ectopic endometrium, and express lowerly in endometrium. The main resource of serum CA19-9 in patients with endometriosis is ectopic endometrium.