Positive correlations between the expression of TGF-β RI and OCT4 and that of migration-related genes in human endometriotic tissues.

Heng-Kien Au (837971), Jui-Hung Chang (837972), Yu-Chih Wu (837973), Yung-Che Kuo (175057), Yu-Hsi Chen (837974), Wei-Chin Lee (837975), Te-Sheng Chang (837976), Pei-Chi Lan (837977), Hung-Chih Kuo (554958), Kha-Liang Lee (837978), Mei-Tsu Lee (837979), Chii-Ruey Tzeng (837980), Yen-Hua Huang (409275)
2015 · doi:10.1371/journal.pone.0145256.g002 · W6922996384
other OA: green CC0
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Abstract

The mRNA levels in endometriotic tissue samples obtained from patients with adenomyosis (n = 23) and chocolate cysts (n = 24) were quantified using reverse transcription and quantitative real-time PCR. The transcriptional levels (ΔCt of gene levels/β2-microglobulin) of (A)OCT4, or (B) migration-related genes of SNAIL, SLUG, or TWIST, were compared with those of TGF-β RI, and (C) The transcriptional levels (ΔCt of gene levels/β2-microglobulin) of SNAIL, SLUG, or TWIST were compared with those of OCT4, using the Pearson correlation analysis to determine the statistical correlations.

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adenomyosis

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