Off-pump coronary artery bypass grafting with malignant tumor resection involving different organs: the comparison of long-term prognosis and risk factor analysis related to survival

Aim: The aim of this study was to analyze the influence of the primary site of tumor location on off-pump coronary artery bypass grafting (OPCABG) surgery combined with concurrent tumor resection, and to identify factors affecting the long-term survival. Materials: and methods: 57 patients with coronary artery disease (CAD) and malignancy underwent simultaneous surgery were retrospectively enrolled. The primary site of tumor locations and cancer stage were used as a basis for grouping. The long-term survival among the subgroups was compared, and the risk factors related to survival was analyzed. Results: : The median follow-up period was 40 months. The 5-year cumulative survival rate of patients undergoing OPCABG and tumor resection was 74%. There was no significant difference in long-term survival among the 4 oncological location subgroups (P=0.8) while significant difference was found among the 2 cancer stage subgroups (P=0.0076). On univariable and multivariable Cox regression analysis, only cancer stage was an independent predictor of the long-term mortality rate (hazard ratio 5.42, P = 0.007).  Conclusion: For patients with potentially curable cancer and surgically correctable CAD, the safety of simultaneous surgery is confident. The primary site of tumor location does not significantly affect the long-term survival of these patients. The long-term survival rate strongly correlates with tumor stage.