Circulating miRNA 27a and miRNA150-5p; a noninvasive approach to endometrial carcinoma

Abstract Background The search for novel non-invasive biomarkers such as epigenetic molecular markers is new hope for common & burdensome cancers. We aim to assess serum expression of miRNA 27a and miRNA150-5p in endometrial cancer patients. Methods Serum was drawn for 36 un-intervened endometrial cancer patients scheduled for hysterectomy & 35 controls. miRNA 27a and miRNA150-5p were measured by real time reverse transcription polymerase chain reaction. Results Significant overexpression of both miRNA in patients (p < 0.001). At cutoffs 0.2872 & 1.02, miRNA 27a showed 100%sensitivity, specificity, positive & negative predictive values. miRNA150-5p showed 88.89%sensitivity, 100%specificity, 100%positive and 78.9%negative predictive values. Areas under curve were 1.0 for miRNA 27a, 0.982 for miRNA 150 performing much better than Ca125. miRNA 27a was significantly associated with type I endometroid endometrial cancer. Conclusion We suggest miRNA 27a and miRNA-150-5P as promising biomarkers of endometrial cancer possibly part of a miRNA panel for management.