Bioinformatics Analysis of Prognostic Significance of VPS72 and Correlations with Immune Infiltrates in Hepatocellular Carcinoma

Abstract Background VPS72 is part of the EP400 and Snf2-related CBP-activator protein (SRCAP) chromatin remodeling complexes, and the prognostic value of VPS72 in hepatocellular carcinoma has not been reported. Methods we used the Oncomine, UALCAN, GEPIA, String and Timer databases to study the expression of VPS72 in hepatocellular carcinoma. Results We found the overexpression of VPS72 was markedly correlated with clinical stages and pathological grades in LIHC, higher mRNA expression of VPS72 was significantly related with shorter overall survival. Moreover, we found that VPS72 promoter hyper-methylation in liver cancer is different and significant. Furthermore, we identified significant correlations among the expression of VPS72 and infiltration of B cells, CD4 + T cells, CD8 + T cells, macrophages, neutrophils, and dendritic cells in LIHC. Then we searched the protein interaction network of VPS72 by string. Conclusion VPS72 may be used as prognostic biomarkers and immunotherapeutic targets LIHC patients.