Synthesis of allylamines from Baylis-Hillman acetates using DBU under solvent free condition

Synthesis of allylamines from Baylis-Hillman acetates using DBU under solvent free condition | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Synthesis of allylamines from Baylis-Hillman acetates using DBU under solvent free condition Sonam Tashi Khom, Pranjit Saikia, Ijaz Ullah Muzaddadi, Arumugam Murugan, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-2840001/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 26 Jun, 2023 Read the published version in Monatshefte für Chemie - Chemical Monthly → Version 1 posted 4 You are reading this latest preprint version Abstract A simple, new and solvent free route to the regioselective and stereoselective synthesis of ( E )- and ( Z )- allylamines has been achieved by the reaction of Baylis-Hillman acetates with various nitrogen nucleophiles in the presence of 1,8-diazabicyclo(5.4.0)undec-7-ene (DBU). This method requires very short reaction time and accomplished by S N 2ʹ nucleophilic substitution pathway. Baylis-Hillman acetates Amines Solvent-free Nucleophilic substitutions DBU Introduction Baylis-Hillman reaction become one of the popular routes with immense synthetic utility for the carbon-carbon bond-forming reactions [ 1 – 6 ]. The easy availability and multi-functionality nature of the Baylis-Hillman adducts makes them an important scaffold for the synthesis of a variety of heterocycles [ 7 – 14 ], natural products [ 15 – 20 ], and multifunctional derivatives of several biologically active compounds [ 21 – 23 ]. Baylis-Hillman adducts and their acetates prove to be potential electrophiles. Their capacity to undergo S N 2 allylic substitution reaction is a major factor in their synthetic utility [ 24 – 33 ]. The substituted allylamines produced by the nucleophilic substitution of Baylis-Hillman acetates were found to be useful synthons for the synthesis of numerous heterocycles and natural products [ 34 – 39 ]. There are few reports in the literature for the preparation of substituted allylamines from Baylis-Hillman acetates. Das et al. have reported the synthesis of allylamines from the reaction between ammonium acetate and the acetates derived from the Baylis-Hillman adducts in anhydrous methanol [ 40 ]. Batra et al. have reported two different methods for the stereoselective synthesis of such allylamines. First method involves the reduction of the allylazides, obtained from the Staudinger reaction of the Baylis-Hillman acetate [ 41 ], while second report describes the synthesis of allylamines using methanolic ammonia [ 42 ]. Roy et al. reported the regioselective synthesis of α-dehydro-β-amino esters from the reaction between Baylis-Hillman acetates and amines catalyzed by ceric ammonium nitrate (CAN) [ 43 ]. Park et al. reported amination of the Baylis-Hillman acetates with amines in ethanol [ 44 ]. Even though some of the reported methods are fairly sophisticated, many tend to involve organic solvents, low regioselectivity, longer reaction time, higher temperature and low yields. Because of numerous applicability of substituted allylamines in synthesis of medicinally viable organic compound, there is scope to develop new and efficient protocols for these allylamines. So, herein we describe the preparation of allylamines from Baylis-Hillman acetates using DBU as a mild reagent under neat condition. This method is simple, requires short reaction time, efficient for practical use and gives the satisfactory yields (46–93%). Results and Discussion In continuation of our research on the Baylis-Hillman chemistry [ 45 ], we developed a new method for the regio- and stereoselective synthesis of allylamines in good yields. For the preliminary study, ethyl 3-acetoxy-2-methylene-3-phenylpropanoate ( 1a ) was reacted with benzylamine ( 2a ) using 1,8-diazabicyclo(5.4.0)undec-7-ene (DBU) as unique base without using solvent at room temperature to give ( E )-ethyl 2-((benzylamino)methyl)-3-phenylacrylate ( 3a ) in 93% yield (Scheme 1 ). The efficiency of DBU as a non-nucleophilic, sterically hindered, tertiary amine base in organic chemistry has been widely used [ 46 , 47 ]. We have screened various reaction conditions such as using solvents like dichloromethane (DCM), tetrahydrofuran (THF), dimethylformamide (DMF) and acetonitrile. The use of DCM as solvent also resulted in the desired product but it took longer reaction time (12 hrs). The rest of the solvents were not efficient enough to give the γ-substituted product even after stirring for longer time (24 hrs). The quantity of DBU was also changed from catalytic to stoichiometric amount and we found that 1.5 equiv. of DBU proved to be the optimum quantity for the reaction. Having this result in hand, several Baylis-Hillman acetates bearing a variety of aryl-substituted moieties ( 1g-m ) were reacted with various amines such as benzylamine, cyclohexylamine, R -phenylethylamine, S -phenylethylamine, diethylamine, n-butylamine, and para-toludines to give respective products in good yields (Table 1). The BH acetate bearing electron donating group (Table 1, entry l and m ) gave low yield as compare to the BH acetate bearing electron withdrawing group (Table 1, entry j and k ). Both aliphatic amines and aniline underwent nucleophilic substitution reaction and furnished products in good yields with high stereoselectivity i.e. E -isomer in case of BH adducts derived from acrylate ester and Z- isomer in case of BH adducts derived from acrylonitrile. Aniline derivatives gives poor yield of corresponding substituted product (Table 1, entry f) along with side product which was formed by the nucleophilic attack by DBU [ 48 ]. It is surprising that reaction of BH acetate with aniline gives only substituted product ( 4 ) in 30 minutes in 95% yields (Scheme 2 ). The product 4 is formed by nucleophilic attack with DBU and no traces of aniline substituted product were observed. The analytical data of compound 4 is in complete agreement with those reported in literature [ 48 ]. This anomalous behavior of DBU mediated reaction with aniline is due to poor nucleophilicity of anilines. All products were characterized by NMR and HRMS techniques and found in good agreement with those reported in literature [ 44 , 48 ]. The stereochemistry of the products was confirmed by comparing the signal of the vinylic methylene proton in 1 H NMR spectra which matched the reported values [ 49 , 50 ]. The peak for the vinylic methylene proton of the E -isomer appears at around δ = 7.8 ppm hereas, for the Z -isomer, the peak was appears around δ = 7.1 ppm in 1 H NMR spectra. The BH acetates undergo Michael type addition reaction followed by acetoxy elimination with amines and other nucleophiles. The role of DBU in this reaction is to accelerate the reaction by neutralizing the free acetic acid formed in the reaction as a side product (Scheme 2 ). This mechanism is supported by the literature report on nucleophilic behaviour of DBU by J. N. Kim et. al.[ 48 ], which describes the nucleophilic substitution of BH acetates with DBU. Conclusion In conclusion, herein we describe an efficient, fast and easy transformation of Baylis-Hillman acetates to allylamines using DBU at room temperature. We also reports an fascile and solvent free synthesis of ( E )-ethyl 2-(3-(2-oxoazepan-1-yl)propylamino)methyl)-3-phenylacrylate in excellent yields in shorter reaction time. The methodology successfully produced stereoselective and regioselective allylamines in good yield which can be utilize for the synthesis of various biologically active compound. The allylamines could be a promising synthon for the synthesis of N-atom heterocyclic compounds. Experimental All chemicals and materials were of reagent grade as received from commercial outlets. The solvents were used without further purification. Baylis-Hillman acetates were prepared as reported [ 3 , 4 , 51 – 55 ]. Purification of the products was carried out by column chromatography using 60–120 mesh silica gel. The 1 H and 13 C NMR were recorded on a Bruker Avance 400 MHz/Avlll HD-300 MHz spectrometer. High-resolution mass spectrometry (HRMS) was determined on Agilent 6520 (Q-TOF) Mass spectrometer with Agilent 1200 HPLC system. General Procedure for preparation of allyamines 1mmol of Baylis-Hillman acetates, ethyl 3-acetoxy-2-methylene-3-phenylpropanoate ( 1a ) was taken in a round bottom flask (25 ml), added amines, benzylamine ( 2a ) (1.2 Equiv). On stirring, DBU (1.5 Equiv) was added dropwise. The reaction was monitored by TLC, which indicated completion of the reaction in 45 mins. After the usual work-up and column chromatographic purification (hexane/ethyl acetate, 1:10) ( 3a ) was obtained as yellowish oil, 0.2745 g (93%). The spectroscopic and analytical data of some representative allylamines are given below. ( E )-Ethyl 2-((benzylamino)methyl)-3-phenylacrylate (3a, C 19 H 21 NO 2 ) : 274.5 mg; yield 93%; viscous oil; R f = 0.43 (EA:Hexane = 1: 10); 1 H NMR (300 MHz, CDCl 3 ) δ = 7.81 (s, 1H), 7.46–7.37 (m, 2H), 7.36–7.19 (m, 8H), 4.27 (q, J = 7.1 Hz, 2H), 3.80 (s, 2H), 3.59 (s, 2H), 2.63 (br s, 1H), 1.34 (t, J = 7.1 Hz, 3H). 13 C NMR (75 MHz, CDCl 3 ) δ = 168.0, 141.7, 139.8, 135.0, 130.6, 129.5, 128.7, 128.3, 128.2, 126.9, 60.8, 53.5, 45.2, 14.2 ppm. HRMS (ESI): m/z calcd for C 19 H 22 NO 2 ([M + H] + ) 296.1651, found 296.1650. ( E )-Ethyl 2-((cyclohexylamino)methyl)-3-phenylacrylate (3b, C 18 H 25 NO 2 ) : 92.5 mg; yield 80%; viscous oil; R f = 0.48 (EA: Hexane = 1: 12.5); 1 H NMR (300 MHz, CDCl 3 ) δ = 7.81 (s, 1H), 7.50 (d, J = 6.8 Hz, 2H), 7.46–7.24 (m, 3H), 4.28 (q, J = 7.1 Hz, 2H), 3.62 (s, 2H), 2.82 (br s, 1H), 2.52–2.38 (m, 1H), 1.86–1.53 (m, 4H), 1.35 (t, J = 7.1 Hz, 3H), 1.32–1.03 (m, 6H). 13 C NMR (75 MHz, CDCl 3 ) δ = 168.0, 141.4, 135.2, 131.0, 129.4, 128.6, 128.3, 60.8, 56.4, 43.0, 33.2, 26.0, 24.8, 14.2 ppm. HRMS (ESI): m/z calcd for C 18 H 26 NO 2 ([M + H] + ) 288.1964, found 288.1961 ( R,E )-Ethyl 3-phenyl-2-((1-phenylethylamino)methyl)acrylate (3c, C 20 H 23 NO 2 ) : 89.7 mg; yield 72%; viscous oil; R f = 0.44 (EA: Hexane = 1: 10); 1 H NMR (300 MHz, CDCl 3 ) δ = 7.76 (s, 1H), 7.44–7.15 (m, 10H), 4.27 (q, J = 7.1 Hz, 2H), 3.78 (q, J = 6.6 Hz, 1H), 3.41 (ABq, J = 11.9 Hz, 2H), 2.32 (br s, 1H), 1.41–1.30 (m, 6H). 13 C NMR (75 MHz, CDCl 3 ) δ = 168.0, 145.0, 141.4, 134.9, 130.6, 129.4, 128.6, 128.2, 126.8, 60.8, 58.4, 44.3, 24.1, 14.2 ppm. HRMS (ESI): m/z calcd for C 20 H 24 NO 2 ([M + H] + ) 310.1807, found 310.1808. ( S , E )-Ethyl 3-phenyl-2-((1-phenylethylamino)methyl)acrylate (3d, C 20 H 23 NO 2 ) : 100.9 mg; yield 81%; viscous oil; R f = 0.44 (EA: Hexane = 1: 10); 1 H NMR (300 MHz, CDCl 3 ) δ 7.76 (s, 1H), 7.42–7.18 (m, 10H), 4.27 (q, J = 7.1 Hz, 2H), 3.78 (q, J = 6.6 Hz, 1H), 3.41 (ABq, J = 11.9 Hz, 2H), 2.21 (br s, 1H), 1.42–1.29 (m, 6H). 13 C NMR (75 MHz, CDCl 3 ) δ = 168.0, 145.0, 141.4, 134.9, 130.6, 129.4, 128.6, 128.2, 126.9, 60.8, 58.4, 44.3, 24.1, 14.2 ppm. HRMS (ESI): m/z calcd for C 20 H 24 NO 2 ([M + H] + ) 310.1807, found 310.1809. ( E )-Ethyl 2-((butylamino)methyl)-3-phenylacrylate (3e, C 16 H 23 NO 2 ) : 90.4 mg; yield 86%; viscous oil; R f = 0.46 (EA: Hexane = 1: 10) 1 H NMR (500 MHz, CDCl 3 ) δ = 7.72 (s, 1H), 7.40 (d, J = 7.5 Hz, 2H), 7.33–7.18 (m, 3H), 4.21 (q, J = 7.1 Hz, 2H), 3.50 (s, 2H), 2.53 (t, J = 7.0 Hz, 2H), 1.96 (br s, 1H), 1.43–1.19 (m, 7H), 0.82 (t, J = 7.3 Hz, 3H). 13 C NMR (126 MHz, CDCl 3 ) δ 168.0, 141.4, 135.243, 131.143, 129.5, 128.6, 128.4, 60.8, 49.1, 45.8, 31.9, 20.4, 14.2, 13.9 ppm. HRMS (ESI): m/z calcd for C 16 H 24 NO 2 ([M + H] + ) 262.1807, found 262.1810. ( E )-Ethyl 3-phenyl-2-((p-tolylamino)methyl)acrylate (3f, C 19 H 21 NO 2 ) : 54.7 mg; yield 46%; viscous oil; R f = 0.52 (EA: Hexane = 1: 25) 1 H NMR (300 MHz, CDCl 3 ) δ = 7.87 (s, 1H), 7.81 (d, J = 7.3 Hz, 1H), 7.54–7.34 (m, 4H), 6.95 (d, J = 8.2 Hz, 2H), 6.45 (d, J = 8.3 Hz, 2H), 4.29 (q, J = 7.1 Hz, 2H), 4.11 (s, 2H), 2.23 (s, 3H), 1.34 (t, J = 7.1 Hz, 3H). HRMS (ESI): m/z calcd for C 19 H 21 NNaO 2 ([M + Na] + ) 318.1470, found 318.1476. ( E )-Ethyl 2-((benzylamino)methyl)-3-(4-chlorophenyl)acrylate (3g, C 19 H 20 ClNO 2 ) : 86.2 mg; yield 74%; viscous oil; R f = 0.42 (EA: Hexane = 1: 10) 1 H NMR (500 MHz, CDCl 3 ) δ = 7.72 (s, 1H), 7.40–7.23 (m, 9H), 4.27 (q, J = 7.1 Hz, 2H), 3.81 (s, 2H), 3.52 (s, 2H), 2.04 (br s, 1H), 1.34 (t, J = 7.1 Hz, 3H). 13 C NMR (126 MHz, CDCl 3 ) δ = 167.8, 140.3, 139.8, 134.7, 133.5, 131.2, 130.9, 128.6, 128.4, 128.3, 126.9, 60.9, 53.7, 45.2, 14.2 ppm. HRMS (ESI): m/z calcd for C 19 H 21 ClNO 2 ([M + H] + ) 330.1261, found 330.1266. ( E )-Ethyl 3-(4-chlorophenyl)-2-((cyclohexylamino)methyl)acrylate (3h, C 18 H 24 ClNO 2 ) : 92.1 mg; yield 81%; viscous oil; R f = 0.48 (EA: Hexane = 1: 12.5) 1 H NMR (500 MHz, CDCl 3 ) δ = 7.72 (s, 1H), 7.50 (d, J = 8.4 Hz, 2H), 7.36 (d, J = 8.5 Hz, 2H), 4.28 (q, J = 7.1 Hz, 2H), 3.56 (s, 2H), 2.50–2.41 (m, 1H), 1.99–1.54 (m, 5H), 1.35 (t, J = 7.1 Hz, 3H), 1.31–1.07 (m, 6H). 13 C NMR (126 MHz, CDCl 3 ) δ = 167.8, 140.0, 134.7, 133.6, 131.6, 130.9, 128.5, 60.8, 56.7, 43.2, 33.3, 26.0, 24.8, 14.2. HRMS (ESI): m/z calcd for C 18 H 25 ClNO 2 ([M + H] + ) 322.1574, found 322.1572. ( E )-Ethyl 2-((butylamino)methyl)-3-(4-chlorophenyl)acrylate (3i, C 16 H 22 ClNO 2 ) : 80.5 mg; yield 77%; viscous oil; R f = 0.46 (EA: Hexane = 1: 10) 1 H NMR (500 MHz, CDCl 3 ) δ = 7.74 (s, 1H), 7.55–7.23 (m, 4H), 4.32–4.25 (m, 2H), 3.54 (s, 2H), 2.67–2.57 (m, 2H), 2.05 (br s, 1H), 1.54–1.17 (m, 7H), 1.01–0.79 (m, 3H). 13 C NMR (126 MHz, CDCl 3 ) δ = 167.8, 140.2, 134.8, 133.6, 131.5, 130.9, 128.7, 61.0, 49.2, 45.8, 31.9, 20.4, 14.2, 13.9 ppm. HRMS (ESI): m/z calcd for C 16 H 23 ClNO 2 ([M + H] + ) 296.1417, found 296.1422. ( E )-Ethyl 2-((benzylamino)methyl)-3-(4-nitrophenyl)acrylate (3j, C 19 H 20 N 2 O 4 ) : 99.7 mg; yield 86%; viscous oil; R f = 0.51 (EA: Hexane = 1: 20) 1 H NMR (300 MHz, CDCl 3 ) δ = 8.11 (d, J = 8.7 Hz, 2H), 7.77 (s, 1H), 7.58 (d, J = 8.7 Hz, 2H), 7.39–7.22 (m, 5H), 4.31 (q, J = 7.1 Hz, 2H), 3.83 (s, 2H), 3.50 (s, 2H), 2.41 (br s, 1H), 1.36 (t, J = 7.1 Hz, 3H). 13 C NMR (75 MHz, CDCl 3 ) δ 167.2, 147.4, 141.4, 139.4, 138.9, 133.8, 130.2, 128.4, 128.3, 127.1, 123.4, 61.3, 53.6, 45.0, 14.2 ppm. HRMS (ESI): m/z calcd for C 19 H 21 N 2 O 4 ([M + H] + ) 341.1501, found 341.1504. ( E )-Ethyl 2-((cyclohexylamino)methyl)-3-(4-nitrophenyl)acrylate (3k, C 18 H 24 N 2 O 4 ) : 90.6 mg; yield 80%; viscous oil; R f = 0.49 (EA: Hexane = 1: 12.5) 1 H NMR (500 MHz, CDCl 3 ) δ = 8.18 (d, J = 8.7 Hz, 2H), 7.72 (s, 1H), 7.67 (d, J = 8.6 Hz, 2H), 4.24 (q, J = 7.1 Hz, 2H), 3.48 (s, 2H), 2.60 (br s, 1H), 2.46–2.37 (m, 1H), 1.80–1.50 (m, 4H), 1.29 (t, J = 7.1 Hz, 3H), 1.25–1.02 (m, 6H). 13 C NMR (101 MHz, CDCl 3 ) δ = 167.3, 147.6, 141.6, 138.9, 130.4, 123.6, 61.3, 56.9, 43.2, 33.1, 26.0, 24.8, 14.2. HRMS (ESI): m/z calcd for C 18 H 25 N 2 O 4 ([M + H] + ) 333.1814, found 333.1816. ( E )-Ethyl 2-((benzylamino)methyl)-3-(4-methoxyphenyl)acrylate (3l, C 20 H 23 NO 3 ) : 85.3 mg; yield 73%; viscous oil; R f = 0.45 (EA: Hexane = 1: 10) 1 H NMR (500 MHz, CDCl 3 ) δ = 7.68 (s, 1H), 7.32 (d, J = 8.7 Hz, 2H), 7.29–7.15 (m, 5H), 6.74 (d, J = 8.7 Hz, 2H), 4.18 (q, J = 7.1 Hz, 2H), 3.76 (s, 2H), 3.73 (s, 3H), 3.53 (s, 2H), 2.54 (br s, 1H), 1.25 (t, J = 7.1 Hz, 3H). 13 C NMR (126 MHz, CDCl 3 ) δ = 168.3, 160.1, 141.6, 139.8, 131.4, 128.4, 128.2, 127.5, 126.9, 113.8, 60.7, 55.1, 53.6, 45.3, 14.2 ppm. HRMS (ESI): m/z calcd for C 20 H 24 NO 3 ([M + H] + ) 326.1756, found 326.1755 . ( E )-Ethyl 2-((cyclohexylamino)methyl)-3-(4-methoxyphenyl)acrylate (3m, C 19 H 27 NO 3 ) : 85.5 mg; yield 75%; viscous oil; R f = 0.47 (EA: Hexane = 1: 10) 1 H NMR (500 MHz, CDCl 3 ) δ = 7.67 (s, 1H), 7.44 (d, J = 8.7 Hz, 2H), 6.84 (d, J = 8.7 Hz, 2H), 4.19 (q, J = 7.1 Hz, 2H), 3.75 (s, 3H), 3.54 (s, 2H), 2.46–2.34 (m, 1H), 1.83–1.46 (m, 4H), 1.26 (t, J = 7.1 Hz, 3H), 1.24–1.02 (m, 6H). 13 C NMR (151 MHz, CDCl 3 ) δ = 168.2, 160.0, 141.3, 131.3, 128.7, 127.6, 113.8, 60.6, 56.7, 55.1, 43.2, 33.1, 26.0, 24.8, 14.2 ppm. HRMS (ESI): m/z calcd for C 19 H 28 NO 3 ([M + H] + ) 318.2069, found 318.2068. ( Z )-2-((Benzylamino)methyl)-3-phenylacrylonitrile (3n, C 17 H 16 N 2 ) : 217.1 mg; yield 88%; viscous oil; R f = 0.50 (EA: Hexane = 1: 20). 1 H NMR (400 MHz, CDCl 3 ) δ 7.79–7.71 (m, 2H), 7.46–7.24 (m, 8H), 7.08 (s, 1H), 3.85 (s, 2H), 3.57 (s, 2H). 13 C NMR (101 MHz, CDCl 3 ) δ = 144.5, 133.1, 130.3, 128.9, 128.8, 128.7, 128.5, 128.2, 127.3, 118.3, 109.6, 52.4, 51.9. HRMS (ESI): m/z calcd for C 17 H 17 N 2 ([M + H] + ) 249.1392, found 249.1396. ( Z )-2-((Cyclohexylamino)methyl)-3-phenylacrylonitrile (3o, C 16 H 20 N 2 ) : 101.4 mg; yield 85%; viscous oil; R f = 0.48 (EA: Hexane = 1: 10) 1 H NMR (500 MHz, CDCl 3 ) δ = 7.83–7.65 (m, 2H), 7.48–7.31 (m, 3H), 7.10 (d, J = 4.4 Hz, 1H), 3.59–3.52 (m, 2H), 2.58–2.42 (m, 1H), 1.98–1.51 (m, 6H), 1.38–1.03 (m, 4H). 13 C NMR (126 MHz, CDCl 3 ) δ = 143.2, 133.2, 129.8, 128.5, 128.5, 118.2, 110.8, 55.0, 50.3, 33.1, 25.7, 24.5 ppm. HRMS (ESI): m/z calcd for C 16 H 21 N 2 ([M + H] + ) 241.1705, found 241.1709. ( E )-Ethyl2-((3-(2-oxoazepan-1-yl)propylamino)methyl)-3-phenylacrylate (4, C 21 H 30 N 2 O 3 ) : 340.2 mg; yield 95%; viscous oil; R f = 0.9 (Acetone: Hexane = 1: 2). 1 H NMR (400 MHz, CDCl 3 ) δ 7.84 (s, 1H), 7.48–7.31 (m, 5H), 4.30 (q, J = 7.1 Hz, 2H), 3.64 (s, 2H), 3.44 (br s, 1H), 3.40 (t, J = 7.1 Hz, 2H), 3.33–3.29 (m, 2H), 2.62 (t, J = 7.1 Hz, 2H), 2.53–2.47 (m, 2H), 1.76–1.57 (m, 8H), 1.36 (t, J = 7.1 Hz, 3H). 13 C NMR (126 MHz, CDCl 3 ) δ = 175.9, 167.7, 142.1, 134.9, 129.9, 129.3, 128.7, 128.4, 60.9, 49.5, 46.1, 45.8, 45.2, 37.0, 29.8, 28.5, 27.7, 23.3, 14.1 ppm. HRMS (ESI): m/z calcd for C 16 H 21 N 2 ([M + H] + ) 359.2335, found 359.2337. Declarations Acknowledgements S.T.K. thank the Ministry of Tribal Affairs (India) for the award of fellowships. For FT-NMR (both proton and carbon) as well as HRMS data, SAIF- CSIR- Central Drugs Research Institute (CDRI), Lucknow (India) was very helpful and provided all the necessary data. 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(1987) Advances in Heterocyclic Chemistry Katrizky AR Ed Academic Press Inc New York Chap. 42, 83. Kim JN, Kim HJ, Gong JH, Im YJ (2001) Bull Korean Chem Soc 22:1053 Buchholz R, Hoffmann HMR (1991) Helv Chim Acta 74:1213 Rajesh S, Banerji B, Iqbal J (2002) J Org Chem 67:7852 And references cited therein. Ciganek E (1997) In Organic Reactions, Paquette LA Ed Wiley New York 51:201 Basavaiah D, Kumaragurubaran N, Sharada DS (2001) Tetrahedron Lett 42:85 Yang KS, Chen K (2000) Org Lett 2:729 Chamakh A, Amri H (1998) Tetrahedron Lett 39:375 Basavaiah D, Kumaragurubaran N (2001) Tetrahedron Lett 42:477 and further references cited therein. Schemes Schemes 1 and 2 are available in the Supplementary Files section. Supplementary Files Graphicalabstract.png scheme1.png scheme2.png Cite Share Download PDF Status: Published Journal Publication published 26 Jun, 2023 Read the published version in Monatshefte für Chemie - Chemical Monthly → Version 1 posted Reviewers agreed at journal 27 Apr, 2023 Reviewers invited by journal 27 Apr, 2023 Editor assigned by journal 24 Apr, 2023 First submitted to journal 21 Apr, 2023 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-2840001","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":195560906,"identity":"5ef6d1e5-ea60-4e86-998f-3c41dcdb5a19","order_by":0,"name":"Sonam Tashi Khom","email":"","orcid":"","institution":"North Eastern Regional Institute of Science and Technology","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Sonam","middleName":"Tashi","lastName":"Khom","suffix":""},{"id":195560907,"identity":"4d15566c-154e-4b31-b9eb-3db2d8453c07","order_by":1,"name":"Pranjit Saikia","email":"","orcid":"","institution":"North Eastern Regional Institute of Science and Technology","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Pranjit","middleName":"","lastName":"Saikia","suffix":""},{"id":195560908,"identity":"e2ba004e-1d8f-4222-acc6-b5329d81d31f","order_by":2,"name":"Ijaz Ullah Muzaddadi","email":"","orcid":"","institution":"North Eastern Regional Institute of Science and Technology","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Ijaz","middleName":"Ullah","lastName":"Muzaddadi","suffix":""},{"id":195560909,"identity":"d29ade19-1834-4f6b-8c64-d83b2c47e209","order_by":3,"name":"Arumugam Murugan","email":"","orcid":"","institution":"North Eastern Regional Institute of Science and Technology","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Arumugam","middleName":"","lastName":"Murugan","suffix":""},{"id":195560910,"identity":"733c906d-7832-4dc7-a64a-d8e4d5e05428","order_by":4,"name":"Nagendra Nath Nath Yadav","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAuklEQVRIiWNgGAWjYHACxgdAggfKkSBKC7MBWAsbCVrYIMrYiHWVuXSPWXVBxT0Z+fkNjB9+MFjkEdRiOeeM2e0ZZ4p5DI4xMEv2MEgUE9RicCPH7DZvWwKPAdBh0kC/JDYQo6WY918Cj3wbA/NvorUw8zYk8DAcY2Aj1pa0YmmeY0CHHUtss+wxIEpL8sbPPDUJ9vLNhw/f+FFRR1gLAwOHAZTBCFRsgE8lHLA/IErZKBgFo2AUjGAAAIOXMeEvUwqJAAAAAElFTkSuQmCC","orcid":"https://orcid.org/0000-0001-5223-8932","institution":"North Eastern Regional Institute of Science and Technology","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Nagendra","middleName":"Nath Nath","lastName":"Yadav","suffix":""}],"badges":[],"createdAt":"2023-04-20 07:53:35","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-2840001/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-2840001/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1007/s00706-023-03095-y","type":"published","date":"2023-06-26T21:27:58+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":44733844,"identity":"7ca02cc2-9adc-4035-b0ed-1f05a6618094","added_by":"auto","created_at":"2023-10-16 22:11:00","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":455934,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-2840001/v1/9af54dac-5d38-47e6-a5af-bc4b2423ade7.pdf"},{"id":36511556,"identity":"63fcce25-b3b9-4809-903b-76abb8cf48e2","added_by":"auto","created_at":"2023-05-02 04:45:57","extension":"png","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":28193,"visible":true,"origin":"","legend":"","description":"","filename":"Graphicalabstract.png","url":"https://assets-eu.researchsquare.com/files/rs-2840001/v1/fedec0be6722b95f97e2e15f.png"},{"id":36511558,"identity":"1d5b8de0-29ec-4800-9b92-1afe3f3d0269","added_by":"auto","created_at":"2023-05-02 04:45:57","extension":"png","order_by":2,"title":"","display":"","copyAsset":false,"role":"supplement","size":13496,"visible":true,"origin":"","legend":"","description":"","filename":"scheme1.png","url":"https://assets-eu.researchsquare.com/files/rs-2840001/v1/d6b4037c41af0dd1f83f2d5f.png"},{"id":36511557,"identity":"c3012fcf-2296-4f2a-8936-82accd00e297","added_by":"auto","created_at":"2023-05-02 04:45:57","extension":"png","order_by":3,"title":"","display":"","copyAsset":false,"role":"supplement","size":29127,"visible":true,"origin":"","legend":"","description":"","filename":"scheme2.png","url":"https://assets-eu.researchsquare.com/files/rs-2840001/v1/9aa34a90b7c3776da774e2f1.png"}],"financialInterests":"","formattedTitle":"Synthesis of allylamines from Baylis-Hillman acetates using DBU under solvent free condition","fulltext":[{"header":"Introduction","content":"\u003cp\u003eBaylis-Hillman reaction become one of the popular routes with immense synthetic utility for the carbon-carbon bond-forming reactions [\u003cspan additionalcitationids=\"CR2 CR3 CR4 CR5\" citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e]. The easy availability and multi-functionality nature of the Baylis-Hillman adducts makes them an important scaffold for the synthesis of a variety of heterocycles [\u003cspan additionalcitationids=\"CR8 CR9 CR10 CR11 CR12 CR13\" citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e], natural products [\u003cspan additionalcitationids=\"CR16 CR17 CR18 CR19\" citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e], and multifunctional derivatives of several biologically active compounds [\u003cspan additionalcitationids=\"CR22\" citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e]. Baylis-Hillman adducts and their acetates prove to be potential electrophiles. Their capacity to undergo S\u003csub\u003eN\u003c/sub\u003e2 allylic substitution reaction is a major factor in their synthetic utility [\u003cspan additionalcitationids=\"CR25 CR26 CR27 CR28 CR29 CR30 CR31 CR32\" citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR33\" class=\"CitationRef\"\u003e33\u003c/span\u003e]. The substituted allylamines produced by the nucleophilic substitution of Baylis-Hillman acetates were found to be useful synthons for the synthesis of numerous heterocycles and natural products [\u003cspan additionalcitationids=\"CR35 CR36 CR37 CR38\" citationid=\"CR34\" class=\"CitationRef\"\u003e34\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR39\" class=\"CitationRef\"\u003e39\u003c/span\u003e]. There are few reports in the literature for the preparation of substituted allylamines from Baylis-Hillman acetates. Das et al. have reported the synthesis of allylamines from the reaction between ammonium acetate and the acetates derived from the Baylis-Hillman adducts in anhydrous methanol [\u003cspan citationid=\"CR40\" class=\"CitationRef\"\u003e40\u003c/span\u003e]. Batra et al. have reported two different methods for the stereoselective synthesis of such allylamines. First method involves the reduction of the allylazides, obtained from the Staudinger reaction of the Baylis-Hillman acetate [\u003cspan citationid=\"CR41\" class=\"CitationRef\"\u003e41\u003c/span\u003e], while second report describes the synthesis of allylamines using methanolic ammonia [\u003cspan citationid=\"CR42\" class=\"CitationRef\"\u003e42\u003c/span\u003e]. Roy et al. reported the regioselective synthesis of α-dehydro-β-amino esters from the reaction between Baylis-Hillman acetates and amines catalyzed by ceric ammonium nitrate (CAN) [\u003cspan citationid=\"CR43\" class=\"CitationRef\"\u003e43\u003c/span\u003e]. Park et al. reported amination of the Baylis-Hillman acetates with amines in ethanol [\u003cspan citationid=\"CR44\" class=\"CitationRef\"\u003e44\u003c/span\u003e]. Even though some of the reported methods are fairly sophisticated, many tend to involve organic solvents, low regioselectivity, longer reaction time, higher temperature and low yields. Because of numerous applicability of substituted allylamines in synthesis of medicinally viable organic compound, there is scope to develop new and efficient protocols for these allylamines. So, herein we describe the preparation of allylamines from Baylis-Hillman acetates using DBU as a mild reagent under neat condition. This method is simple, requires short reaction time, efficient for practical use and gives the satisfactory yields (46\u0026ndash;93%).\u003c/p\u003e"},{"header":"Results and Discussion","content":"\u003cp\u003eIn continuation of our research on the Baylis-Hillman chemistry [\u003cspan citationid=\"CR45\" class=\"CitationRef\"\u003e45\u003c/span\u003e], we developed a new method for the regio- and stereoselective synthesis of allylamines in good yields. For the preliminary study, ethyl 3-acetoxy-2-methylene-3-phenylpropanoate (\u003cb\u003e1a\u003c/b\u003e) was reacted with benzylamine (\u003cb\u003e2a\u003c/b\u003e) using 1,8-diazabicyclo(5.4.0)undec-7-ene (DBU) as unique base without using solvent at room temperature to give (\u003cem\u003eE\u003c/em\u003e)-ethyl 2-((benzylamino)methyl)-3-phenylacrylate (\u003cb\u003e3a\u003c/b\u003e) in 93% yield (Scheme \u003cspan refid=\"Sch1\" class=\"InternalRef\"\u003e1\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eThe efficiency of DBU as a non-nucleophilic, sterically hindered, tertiary amine base in organic chemistry has been widely used [\u003cspan citationid=\"CR46\" class=\"CitationRef\"\u003e46\u003c/span\u003e, \u003cspan citationid=\"CR47\" class=\"CitationRef\"\u003e47\u003c/span\u003e]. We have screened various reaction conditions such as using solvents like dichloromethane (DCM), tetrahydrofuran (THF), dimethylformamide (DMF) and acetonitrile. The use of DCM as solvent also resulted in the desired product but it took longer reaction time (12 hrs). The rest of the solvents were not efficient enough to give the γ-substituted product even after stirring for longer time (24 hrs). The quantity of DBU was also changed from catalytic to stoichiometric amount and we found that 1.5 equiv. of DBU proved to be the optimum quantity for the reaction. Having this result in hand, several Baylis-Hillman acetates bearing a variety of aryl-substituted moieties (\u003cb\u003e1g-m\u003c/b\u003e) were reacted with various amines such as benzylamine, cyclohexylamine, \u003cem\u003eR\u003c/em\u003e-phenylethylamine, \u003cem\u003eS\u003c/em\u003e-phenylethylamine, diethylamine, n-butylamine, and para-toludines to give respective products in good yields (Table\u0026nbsp;1). The BH acetate bearing electron donating group (Table\u0026nbsp;1, entry \u003cb\u003el\u003c/b\u003e and \u003cb\u003em\u003c/b\u003e) gave low yield as compare to the BH acetate bearing electron withdrawing group (Table\u0026nbsp;1, entry \u003cb\u003ej\u003c/b\u003e and \u003cb\u003ek\u003c/b\u003e). Both aliphatic amines and aniline underwent nucleophilic substitution reaction and furnished products in good yields with high stereoselectivity \u003cem\u003ei.e. E\u003c/em\u003e-isomer in case of BH adducts derived from acrylate ester and Z- isomer in case of BH adducts derived from acrylonitrile.\u003c/p\u003e\u003cp\u003e\u003cimg 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\"\u003e\u003cbr\u003e\u003c/p\u003e\u003cp\u003eAniline derivatives gives poor yield of corresponding substituted product (Table\u0026nbsp;1, entry f) along with side product which was formed by the nucleophilic attack by DBU [\u003cspan citationid=\"CR48\" class=\"CitationRef\"\u003e48\u003c/span\u003e]. It is surprising that reaction of BH acetate with aniline gives only substituted product (\u003cb\u003e4\u003c/b\u003e) in 30 minutes in 95% yields (Scheme \u003cspan refid=\"Sch2\" class=\"InternalRef\"\u003e2\u003c/span\u003e). The product \u003cb\u003e4\u003c/b\u003e is formed by nucleophilic attack with DBU and no traces of aniline substituted product were observed. The analytical data of compound \u003cb\u003e4\u003c/b\u003e is in complete agreement with those reported in literature [\u003cspan citationid=\"CR48\" class=\"CitationRef\"\u003e48\u003c/span\u003e]. This anomalous behavior of DBU mediated reaction with aniline is due to poor nucleophilicity of anilines.\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003eAll products were characterized by NMR and HRMS techniques and found in good agreement with those reported in literature [\u003cspan citationid=\"CR44\" class=\"CitationRef\"\u003e44\u003c/span\u003e, \u003cspan citationid=\"CR48\" class=\"CitationRef\"\u003e48\u003c/span\u003e]. The stereochemistry of the products was confirmed by comparing the signal of the vinylic methylene proton in \u003csup\u003e1\u003c/sup\u003eH NMR spectra which matched the reported values [\u003cspan citationid=\"CR49\" class=\"CitationRef\"\u003e49\u003c/span\u003e, \u003cspan citationid=\"CR50\" class=\"CitationRef\"\u003e50\u003c/span\u003e]. The peak for the vinylic methylene proton of the \u003cem\u003eE\u003c/em\u003e-isomer appears at around \u003cem\u003eδ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.8 ppm hereas, for the \u003cem\u003eZ\u003c/em\u003e-isomer, the peak was appears around \u003cem\u003eδ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 ppm in \u003csup\u003e1\u003c/sup\u003eH NMR spectra.\u003c/p\u003e \u003cp\u003eThe BH acetates undergo Michael type addition reaction followed by acetoxy elimination with amines and other nucleophiles. The role of DBU in this reaction is to accelerate the reaction by neutralizing the free acetic acid formed in the reaction as a side product (Scheme \u003cspan refid=\"Sch2\" class=\"InternalRef\"\u003e2\u003c/span\u003e). This mechanism is supported by the literature report on nucleophilic behaviour of DBU by J. N. Kim et. al.[\u003cspan citationid=\"CR48\" class=\"CitationRef\"\u003e48\u003c/span\u003e], which describes the nucleophilic substitution of BH acetates with DBU.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eIn conclusion, herein we describe an efficient, fast and easy transformation of Baylis-Hillman acetates to allylamines using DBU at room temperature. We also reports an fascile and solvent free synthesis of (\u003cem\u003eE\u003c/em\u003e)-ethyl 2-(3-(2-oxoazepan-1-yl)propylamino)methyl)-3-phenylacrylate in excellent yields in shorter reaction time. The methodology successfully produced stereoselective and regioselective allylamines in good yield which can be utilize for the synthesis of various biologically active compound. The allylamines could be a promising synthon for the synthesis of N-atom heterocyclic compounds.\u003c/p\u003e"},{"header":"Experimental","content":"\u003cp\u003eAll chemicals and materials were of reagent grade as received from commercial outlets. The solvents were used without further purification. Baylis-Hillman acetates were prepared as reported [\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e, \u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e, \u003cspan additionalcitationids=\"CR52 CR53 CR54\" citationid=\"CR51\" class=\"CitationRef\"\u003e51\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR55\" class=\"CitationRef\"\u003e55\u003c/span\u003e]. Purification of the products was carried out by column chromatography using 60\u0026ndash;120 mesh silica gel. The \u003csup\u003e1\u003c/sup\u003eH and \u003csup\u003e13\u003c/sup\u003eC NMR were recorded on a Bruker Avance 400 MHz/Avlll HD-300 MHz spectrometer. High-resolution mass spectrometry (HRMS) was determined on Agilent 6520 (Q-TOF) Mass spectrometer with Agilent 1200 HPLC system.\u003c/p\u003e\n\u003ch3\u003eGeneral Procedure for preparation of allyamines\u003c/h3\u003e\n\u003cp\u003e1mmol of Baylis-Hillman acetates, ethyl 3-acetoxy-2-methylene-3-phenylpropanoate (\u003cb\u003e1a\u003c/b\u003e) was taken in a round bottom flask (25 ml), added amines, benzylamine (\u003cb\u003e2a\u003c/b\u003e) (1.2 Equiv). On stirring, DBU (1.5 Equiv) was added dropwise. The reaction was monitored by TLC, which indicated completion of the reaction in 45 mins. After the usual work-up and column chromatographic purification (hexane/ethyl acetate, 1:10) (\u003cb\u003e3a\u003c/b\u003e) was obtained as yellowish oil, 0.2745 g (93%). The spectroscopic and analytical data of some representative allylamines are given below.\u003c/p\u003e \u003cp\u003e \u003cb\u003e(\u003c/b\u003e \u003cspan type=\"BoldItalic\" class=\"BoldItalic\" name=\"Emphasis\"\u003eE\u003c/span\u003e \u003cb\u003e)-Ethyl 2-((benzylamino)methyl)-3-phenylacrylate (3a, C\u003c/b\u003e \u003csub\u003e \u003cb\u003e19\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eH\u003c/b\u003e \u003csub\u003e \u003cb\u003e21\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eNO\u003c/b\u003e \u003csub\u003e \u003cb\u003e2\u003c/b\u003e \u003c/sub\u003e \u003cb\u003e)\u003c/b\u003e: 274.5 mg; yield 93%; viscous oil; \u003cem\u003eR\u003c/em\u003e\u003csub\u003e\u003cem\u003ef\u003c/em\u003e\u003c/sub\u003e = 0.43 (EA:Hexane\u0026thinsp;=\u0026thinsp;1: 10); \u003csup\u003e1\u003c/sup\u003eH NMR (300 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) \u003cem\u003eδ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.81 (s, 1H), 7.46\u0026ndash;7.37 (m, 2H), 7.36\u0026ndash;7.19 (m, 8H), 4.27 (q, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 Hz, 2H), 3.80 (s, 2H), 3.59 (s, 2H), 2.63 (br s, 1H), 1.34 (t, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 Hz, 3H). \u003csup\u003e13\u003c/sup\u003eC NMR (75 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) \u003cem\u003eδ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;168.0, 141.7, 139.8, 135.0, 130.6, 129.5, 128.7, 128.3, 128.2, 126.9, 60.8, 53.5, 45.2, 14.2 ppm. HRMS (ESI): \u003cem\u003em/z\u003c/em\u003e calcd for C\u003csub\u003e19\u003c/sub\u003eH\u003csub\u003e22\u003c/sub\u003eNO\u003csub\u003e2\u003c/sub\u003e ([M\u0026thinsp;+\u0026thinsp;H]\u003csup\u003e+\u003c/sup\u003e) 296.1651, found 296.1650.\u003c/p\u003e \u003cp\u003e \u003cb\u003e(\u003c/b\u003e \u003cspan type=\"BoldItalic\" class=\"BoldItalic\" name=\"Emphasis\"\u003eE\u003c/span\u003e \u003cb\u003e)-Ethyl 2-((cyclohexylamino)methyl)-3-phenylacrylate (3b, C\u003c/b\u003e \u003csub\u003e \u003cb\u003e18\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eH\u003c/b\u003e \u003csub\u003e \u003cb\u003e25\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eNO\u003c/b\u003e \u003csub\u003e \u003cb\u003e2\u003c/b\u003e \u003c/sub\u003e \u003cb\u003e)\u003c/b\u003e: 92.5 mg; yield 80%; viscous oil; \u003cem\u003eR\u003c/em\u003e\u003csub\u003e\u003cem\u003ef\u003c/em\u003e\u003c/sub\u003e = 0.48 (EA: Hexane\u0026thinsp;=\u0026thinsp;1: 12.5); \u003csup\u003e1\u003c/sup\u003eH NMR (300 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) \u003cem\u003eδ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.81 (s, 1H), 7.50 (d, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;6.8 Hz, 2H), 7.46\u0026ndash;7.24 (m, 3H), 4.28 (q, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 Hz, 2H), 3.62 (s, 2H), 2.82 (br s, 1H), 2.52\u0026ndash;2.38 (m, 1H), 1.86\u0026ndash;1.53 (m, 4H), 1.35 (t, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 Hz, 3H), 1.32\u0026ndash;1.03 (m, 6H). \u003csup\u003e13\u003c/sup\u003eC NMR (75 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) \u003cem\u003eδ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;168.0, 141.4, 135.2, 131.0, 129.4, 128.6, 128.3, 60.8, 56.4, 43.0, 33.2, 26.0, 24.8, 14.2 ppm. HRMS (ESI): \u003cem\u003em/z\u003c/em\u003e calcd for C\u003csub\u003e18\u003c/sub\u003eH\u003csub\u003e26\u003c/sub\u003eNO\u003csub\u003e2\u003c/sub\u003e ([M\u0026thinsp;+\u0026thinsp;H]\u003csup\u003e+\u003c/sup\u003e) 288.1964, found 288.1961\u003c/p\u003e \u003cp\u003e \u003cb\u003e(\u003c/b\u003e \u003cspan type=\"BoldItalic\" class=\"BoldItalic\" name=\"Emphasis\"\u003eR,E\u003c/span\u003e \u003cb\u003e)-Ethyl 3-phenyl-2-((1-phenylethylamino)methyl)acrylate (3c, C\u003c/b\u003e \u003csub\u003e \u003cb\u003e20\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eH\u003c/b\u003e \u003csub\u003e \u003cb\u003e23\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eNO\u003c/b\u003e \u003csub\u003e \u003cb\u003e2\u003c/b\u003e \u003c/sub\u003e \u003cb\u003e)\u003c/b\u003e: 89.7 mg; yield 72%; viscous oil; \u003cem\u003eR\u003c/em\u003e\u003csub\u003e\u003cem\u003ef\u003c/em\u003e\u003c/sub\u003e = 0.44 (EA: Hexane\u0026thinsp;=\u0026thinsp;1: 10); \u003csup\u003e1\u003c/sup\u003eH NMR (300 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) \u003cem\u003eδ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.76 (s, 1H), 7.44\u0026ndash;7.15 (m, 10H), 4.27 (q, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 Hz, 2H), 3.78 (q, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;6.6 Hz, 1H), 3.41 (ABq, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;11.9 Hz, 2H), 2.32 (br s, 1H), 1.41\u0026ndash;1.30 (m, 6H). \u003csup\u003e13\u003c/sup\u003eC NMR (75 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) \u003cem\u003eδ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;168.0, 145.0, 141.4, 134.9, 130.6, 129.4, 128.6, 128.2, 126.8, 60.8, 58.4, 44.3, 24.1, 14.2 ppm. HRMS (ESI): \u003cem\u003em/z\u003c/em\u003e calcd for C\u003csub\u003e20\u003c/sub\u003eH\u003csub\u003e24\u003c/sub\u003eNO\u003csub\u003e2\u003c/sub\u003e ([M\u0026thinsp;+\u0026thinsp;H]\u003csup\u003e+\u003c/sup\u003e) 310.1807, found 310.1808.\u003c/p\u003e \u003cp\u003e \u003cb\u003e(\u003c/b\u003e \u003cspan type=\"BoldItalic\" class=\"BoldItalic\" name=\"Emphasis\"\u003eS\u003c/span\u003e,\u003cspan type=\"BoldItalic\" class=\"BoldItalic\" name=\"Emphasis\"\u003eE\u003c/span\u003e\u003cb\u003e)-Ethyl 3-phenyl-2-((1-phenylethylamino)methyl)acrylate (3d, C\u003c/b\u003e\u003csub\u003e\u003cb\u003e20\u003c/b\u003e\u003c/sub\u003e\u003cb\u003eH\u003c/b\u003e\u003csub\u003e\u003cb\u003e23\u003c/b\u003e\u003c/sub\u003e\u003cb\u003eNO\u003c/b\u003e\u003csub\u003e\u003cb\u003e2\u003c/b\u003e\u003c/sub\u003e\u003cb\u003e)\u003c/b\u003e: 100.9 mg; yield 81%; viscous oil; \u003cem\u003eR\u003c/em\u003e\u003csub\u003e\u003cem\u003ef\u003c/em\u003e\u003c/sub\u003e = 0.44 (EA: Hexane\u0026thinsp;=\u0026thinsp;1: 10); \u003csup\u003e1\u003c/sup\u003eH NMR (300 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) δ 7.76 (s, 1H), 7.42\u0026ndash;7.18 (m, 10H), 4.27 (q, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 Hz, 2H), 3.78 (q, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;6.6 Hz, 1H), 3.41 (ABq, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;11.9 Hz, 2H), 2.21 (br s, 1H), 1.42\u0026ndash;1.29 (m, 6H). \u003csup\u003e13\u003c/sup\u003eC NMR (75 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) \u003cem\u003eδ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;168.0, 145.0, 141.4, 134.9, 130.6, 129.4, 128.6, 128.2, 126.9, 60.8, 58.4, 44.3, 24.1, 14.2 ppm. HRMS (ESI): \u003cem\u003em/z\u003c/em\u003e calcd for C\u003csub\u003e20\u003c/sub\u003eH\u003csub\u003e24\u003c/sub\u003eNO\u003csub\u003e2\u003c/sub\u003e ([M\u0026thinsp;+\u0026thinsp;H]\u003csup\u003e+\u003c/sup\u003e) 310.1807, found 310.1809.\u003c/p\u003e \u003cp\u003e \u003cb\u003e(\u003c/b\u003e \u003cspan type=\"BoldItalic\" class=\"BoldItalic\" name=\"Emphasis\"\u003eE\u003c/span\u003e \u003cb\u003e)-Ethyl 2-((butylamino)methyl)-3-phenylacrylate (3e, C\u003c/b\u003e \u003csub\u003e \u003cb\u003e16\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eH\u003c/b\u003e \u003csub\u003e \u003cb\u003e23\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eNO\u003c/b\u003e \u003csub\u003e \u003cb\u003e2\u003c/b\u003e \u003c/sub\u003e \u003cb\u003e)\u003c/b\u003e: 90.4 mg; yield 86%; viscous oil; \u003cem\u003eR\u003c/em\u003e\u003csub\u003e\u003cem\u003ef\u003c/em\u003e\u003c/sub\u003e = 0.46 (EA: Hexane\u0026thinsp;=\u0026thinsp;1: 10) \u003csup\u003e1\u003c/sup\u003eH NMR (500 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) \u003cem\u003eδ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.72 (s, 1H), 7.40 (d, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.5 Hz, 2H), 7.33\u0026ndash;7.18 (m, 3H), 4.21 (q, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 Hz, 2H), 3.50 (s, 2H), 2.53 (t, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.0 Hz, 2H), 1.96 (br s, 1H), 1.43\u0026ndash;1.19 (m, 7H), 0.82 (t, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.3 Hz, 3H). \u003csup\u003e13\u003c/sup\u003eC NMR (126 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) δ 168.0, 141.4, 135.243, 131.143, 129.5, 128.6, 128.4, 60.8, 49.1, 45.8, 31.9, 20.4, 14.2, 13.9 ppm. HRMS (ESI): \u003cem\u003em/z\u003c/em\u003e calcd for C\u003csub\u003e16\u003c/sub\u003eH\u003csub\u003e24\u003c/sub\u003eNO\u003csub\u003e2\u003c/sub\u003e ([M\u0026thinsp;+\u0026thinsp;H]\u003csup\u003e+\u003c/sup\u003e) 262.1807, found 262.1810.\u003c/p\u003e \u003cp\u003e \u003cb\u003e(\u003c/b\u003e \u003cspan type=\"BoldItalic\" class=\"BoldItalic\" name=\"Emphasis\"\u003eE\u003c/span\u003e \u003cb\u003e)-Ethyl 3-phenyl-2-((p-tolylamino)methyl)acrylate (3f, C\u003c/b\u003e \u003csub\u003e \u003cb\u003e19\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eH\u003c/b\u003e \u003csub\u003e \u003cb\u003e21\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eNO\u003c/b\u003e \u003csub\u003e \u003cb\u003e2\u003c/b\u003e \u003c/sub\u003e \u003cb\u003e)\u003c/b\u003e: 54.7 mg; yield 46%; viscous oil; \u003cem\u003eR\u003c/em\u003e\u003csub\u003e\u003cem\u003ef\u003c/em\u003e\u003c/sub\u003e = 0.52 (EA: Hexane\u0026thinsp;=\u0026thinsp;1: 25) \u003csup\u003e1\u003c/sup\u003eH NMR (300 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) \u003cem\u003eδ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.87 (s, 1H), 7.81 (d, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.3 Hz, 1H), 7.54\u0026ndash;7.34 (m, 4H), 6.95 (d, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;8.2 Hz, 2H), 6.45 (d, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;8.3 Hz, 2H), 4.29 (q, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 Hz, 2H), 4.11 (s, 2H), 2.23 (s, 3H), 1.34 (t, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 Hz, 3H). HRMS (ESI): \u003cem\u003em/z\u003c/em\u003e calcd for C\u003csub\u003e19\u003c/sub\u003eH\u003csub\u003e21\u003c/sub\u003eNNaO\u003csub\u003e2\u003c/sub\u003e ([M\u0026thinsp;+\u0026thinsp;Na]\u003csup\u003e+\u003c/sup\u003e) 318.1470, found 318.1476.\u003c/p\u003e \u003cp\u003e \u003cb\u003e(\u003c/b\u003e \u003cspan type=\"BoldItalic\" class=\"BoldItalic\" name=\"Emphasis\"\u003eE\u003c/span\u003e \u003cb\u003e)-Ethyl 2-((benzylamino)methyl)-3-(4-chlorophenyl)acrylate (3g, C\u003c/b\u003e \u003csub\u003e \u003cb\u003e19\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eH\u003c/b\u003e \u003csub\u003e \u003cb\u003e20\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eClNO\u003c/b\u003e \u003csub\u003e \u003cb\u003e2\u003c/b\u003e \u003c/sub\u003e \u003cb\u003e)\u003c/b\u003e: 86.2 mg; yield 74%; viscous oil; \u003cem\u003eR\u003c/em\u003e\u003csub\u003e\u003cem\u003ef\u003c/em\u003e\u003c/sub\u003e = 0.42 (EA: Hexane\u0026thinsp;=\u0026thinsp;1: 10) \u003csup\u003e1\u003c/sup\u003eH NMR (500 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) \u003cem\u003eδ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.72 (s, 1H), 7.40\u0026ndash;7.23 (m, 9H), 4.27 (q, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 Hz, 2H), 3.81 (s, 2H), 3.52 (s, 2H), 2.04 (br s, 1H), 1.34 (t, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 Hz, 3H). \u003csup\u003e13\u003c/sup\u003eC NMR (126 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) \u003cem\u003eδ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;167.8, 140.3, 139.8, 134.7, 133.5, 131.2, 130.9, 128.6, 128.4, 128.3, 126.9, 60.9, 53.7, 45.2, 14.2 ppm. HRMS (ESI): \u003cem\u003em/z\u003c/em\u003e calcd for C\u003csub\u003e19\u003c/sub\u003eH\u003csub\u003e21\u003c/sub\u003eClNO\u003csub\u003e2\u003c/sub\u003e ([M\u0026thinsp;+\u0026thinsp;H]\u003csup\u003e+\u003c/sup\u003e) 330.1261, found 330.1266.\u003c/p\u003e \u003cp\u003e \u003cb\u003e(\u003c/b\u003e \u003cspan type=\"BoldItalic\" class=\"BoldItalic\" name=\"Emphasis\"\u003eE\u003c/span\u003e \u003cb\u003e)-Ethyl 3-(4-chlorophenyl)-2-((cyclohexylamino)methyl)acrylate (3h, C\u003c/b\u003e \u003csub\u003e \u003cb\u003e18\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eH\u003c/b\u003e \u003csub\u003e \u003cb\u003e24\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eClNO\u003c/b\u003e \u003csub\u003e \u003cb\u003e2\u003c/b\u003e \u003c/sub\u003e \u003cb\u003e)\u003c/b\u003e: 92.1 mg; yield 81%; viscous oil; \u003cem\u003eR\u003c/em\u003e\u003csub\u003e\u003cem\u003ef\u003c/em\u003e\u003c/sub\u003e = 0.48 (EA: Hexane\u0026thinsp;=\u0026thinsp;1: 12.5) \u003csup\u003e1\u003c/sup\u003eH NMR (500 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) \u003cem\u003eδ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.72 (s, 1H), 7.50 (d, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;8.4 Hz, 2H), 7.36 (d, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;8.5 Hz, 2H), 4.28 (q, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 Hz, 2H), 3.56 (s, 2H), 2.50\u0026ndash;2.41 (m, 1H), 1.99\u0026ndash;1.54 (m, 5H), 1.35 (t, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 Hz, 3H), 1.31\u0026ndash;1.07 (m, 6H). \u003csup\u003e13\u003c/sup\u003eC NMR (126 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) \u003cem\u003eδ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;167.8, 140.0, 134.7, 133.6, 131.6, 130.9, 128.5, 60.8, 56.7, 43.2, 33.3, 26.0, 24.8, 14.2. HRMS (ESI): \u003cem\u003em/z\u003c/em\u003e calcd for C\u003csub\u003e18\u003c/sub\u003eH\u003csub\u003e25\u003c/sub\u003eClNO\u003csub\u003e2\u003c/sub\u003e ([M\u0026thinsp;+\u0026thinsp;H]\u003csup\u003e+\u003c/sup\u003e) 322.1574, found 322.1572.\u003c/p\u003e \u003cp\u003e \u003cb\u003e(\u003c/b\u003e \u003cspan type=\"BoldItalic\" class=\"BoldItalic\" name=\"Emphasis\"\u003eE\u003c/span\u003e \u003cb\u003e)-Ethyl 2-((butylamino)methyl)-3-(4-chlorophenyl)acrylate (3i, C\u003c/b\u003e \u003csub\u003e \u003cb\u003e16\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eH\u003c/b\u003e \u003csub\u003e \u003cb\u003e22\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eClNO\u003c/b\u003e \u003csub\u003e \u003cb\u003e2\u003c/b\u003e \u003c/sub\u003e \u003cb\u003e)\u003c/b\u003e: 80.5 mg; yield 77%; viscous oil; \u003cem\u003eR\u003c/em\u003e\u003csub\u003e\u003cem\u003ef\u003c/em\u003e\u003c/sub\u003e = 0.46 (EA: Hexane\u0026thinsp;=\u0026thinsp;1: 10) \u003csup\u003e1\u003c/sup\u003eH NMR (500 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) \u003cem\u003eδ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.74 (s, 1H), 7.55\u0026ndash;7.23 (m, 4H), 4.32\u0026ndash;4.25 (m, 2H), 3.54 (s, 2H), 2.67\u0026ndash;2.57 (m, 2H), 2.05 (br s, 1H), 1.54\u0026ndash;1.17 (m, 7H), 1.01\u0026ndash;0.79 (m, 3H). \u003csup\u003e13\u003c/sup\u003eC NMR (126 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) \u003cem\u003eδ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;167.8, 140.2, 134.8, 133.6, 131.5, 130.9, 128.7, 61.0, 49.2, 45.8, 31.9, 20.4, 14.2, 13.9 ppm. HRMS (ESI): \u003cem\u003em/z\u003c/em\u003e calcd for C\u003csub\u003e16\u003c/sub\u003eH\u003csub\u003e23\u003c/sub\u003eClNO\u003csub\u003e2\u003c/sub\u003e ([M\u0026thinsp;+\u0026thinsp;H]\u003csup\u003e+\u003c/sup\u003e) 296.1417, found 296.1422.\u003c/p\u003e \u003cp\u003e \u003cb\u003e(\u003c/b\u003e \u003cspan type=\"BoldItalic\" class=\"BoldItalic\" name=\"Emphasis\"\u003eE\u003c/span\u003e \u003cb\u003e)-Ethyl 2-((benzylamino)methyl)-3-(4-nitrophenyl)acrylate (3j, C\u003c/b\u003e \u003csub\u003e \u003cb\u003e19\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eH\u003c/b\u003e \u003csub\u003e \u003cb\u003e20\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eN\u003c/b\u003e \u003csub\u003e \u003cb\u003e2\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eO\u003c/b\u003e \u003csub\u003e \u003cb\u003e4\u003c/b\u003e \u003c/sub\u003e \u003cb\u003e)\u003c/b\u003e: 99.7 mg; yield 86%; viscous oil; \u003cem\u003eR\u003c/em\u003e\u003csub\u003e\u003cem\u003ef\u003c/em\u003e\u003c/sub\u003e = 0.51 (EA: Hexane\u0026thinsp;=\u0026thinsp;1: 20) \u003csup\u003e1\u003c/sup\u003eH NMR (300 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) \u003cem\u003eδ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;8.11 (d, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;8.7 Hz, 2H), 7.77 (s, 1H), 7.58 (d, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;8.7 Hz, 2H), 7.39\u0026ndash;7.22 (m, 5H), 4.31 (q, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 Hz, 2H), 3.83 (s, 2H), 3.50 (s, 2H), 2.41 (br s, 1H), 1.36 (t, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 Hz, 3H). \u003csup\u003e13\u003c/sup\u003eC NMR (75 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) δ 167.2, 147.4, 141.4, 139.4, 138.9, 133.8, 130.2, 128.4, 128.3, 127.1, 123.4, 61.3, 53.6, 45.0, 14.2 ppm. HRMS (ESI): \u003cem\u003em/z\u003c/em\u003e calcd for C\u003csub\u003e19\u003c/sub\u003eH\u003csub\u003e21\u003c/sub\u003eN\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e ([M\u0026thinsp;+\u0026thinsp;H]\u003csup\u003e+\u003c/sup\u003e) 341.1501, found 341.1504.\u003c/p\u003e \u003cp\u003e \u003cb\u003e(\u003c/b\u003e \u003cspan type=\"BoldItalic\" class=\"BoldItalic\" name=\"Emphasis\"\u003eE\u003c/span\u003e \u003cb\u003e)-Ethyl 2-((cyclohexylamino)methyl)-3-(4-nitrophenyl)acrylate (3k, C\u003c/b\u003e \u003csub\u003e \u003cb\u003e18\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eH\u003c/b\u003e \u003csub\u003e \u003cb\u003e24\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eN\u003c/b\u003e \u003csub\u003e \u003cb\u003e2\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eO\u003c/b\u003e \u003csub\u003e \u003cb\u003e4\u003c/b\u003e \u003c/sub\u003e \u003cb\u003e)\u003c/b\u003e: 90.6 mg; yield 80%; viscous oil; \u003cem\u003eR\u003c/em\u003e\u003csub\u003e\u003cem\u003ef\u003c/em\u003e\u003c/sub\u003e = 0.49 (EA: Hexane\u0026thinsp;=\u0026thinsp;1: 12.5) \u003csup\u003e1\u003c/sup\u003eH NMR (500 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) \u003cem\u003eδ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;8.18 (d, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;8.7 Hz, 2H), 7.72 (s, 1H), 7.67 (d, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;8.6 Hz, 2H), 4.24 (q, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 Hz, 2H), 3.48 (s, 2H), 2.60 (br s, 1H), 2.46\u0026ndash;2.37 (m, 1H), 1.80\u0026ndash;1.50 (m, 4H), 1.29 (t, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 Hz, 3H), 1.25\u0026ndash;1.02 (m, 6H). \u003csup\u003e13\u003c/sup\u003eC NMR (101 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) δ\u0026thinsp;=\u0026thinsp;167.3, 147.6, 141.6, 138.9, 130.4, 123.6, 61.3, 56.9, 43.2, 33.1, 26.0, 24.8, 14.2. HRMS (ESI): \u003cem\u003em/z\u003c/em\u003e calcd for C\u003csub\u003e18\u003c/sub\u003eH\u003csub\u003e25\u003c/sub\u003eN\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e ([M\u0026thinsp;+\u0026thinsp;H]\u003csup\u003e+\u003c/sup\u003e) 333.1814, found 333.1816.\u003c/p\u003e \u003cp\u003e \u003cb\u003e(\u003c/b\u003e \u003cspan type=\"BoldItalic\" class=\"BoldItalic\" name=\"Emphasis\"\u003eE\u003c/span\u003e \u003cb\u003e)-Ethyl 2-((benzylamino)methyl)-3-(4-methoxyphenyl)acrylate (3l, C\u003c/b\u003e \u003csub\u003e \u003cb\u003e20\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eH\u003c/b\u003e \u003csub\u003e \u003cb\u003e23\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eNO\u003c/b\u003e \u003csub\u003e \u003cb\u003e3\u003c/b\u003e \u003c/sub\u003e \u003cb\u003e)\u003c/b\u003e: 85.3 mg; yield 73%; viscous oil; \u003cem\u003eR\u003c/em\u003e\u003csub\u003e\u003cem\u003ef\u003c/em\u003e\u003c/sub\u003e = 0.45 (EA: Hexane\u0026thinsp;=\u0026thinsp;1: 10) \u003csup\u003e1\u003c/sup\u003eH NMR (500 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) \u003cem\u003eδ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.68 (s, 1H), 7.32 (d, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;8.7 Hz, 2H), 7.29\u0026ndash;7.15 (m, 5H), 6.74 (d, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;8.7 Hz, 2H), 4.18 (q, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 Hz, 2H), 3.76 (s, 2H), 3.73 (s, 3H), 3.53 (s, 2H), 2.54 (br s, 1H), 1.25 (t, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 Hz, 3H). \u003csup\u003e13\u003c/sup\u003eC NMR (126 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) \u003cem\u003eδ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;168.3, 160.1, 141.6, 139.8, 131.4, 128.4, 128.2, 127.5, 126.9, 113.8, 60.7, 55.1, 53.6, 45.3, 14.2 ppm. HRMS (ESI): \u003cem\u003em/z\u003c/em\u003e calcd for C\u003csub\u003e20\u003c/sub\u003eH\u003csub\u003e24\u003c/sub\u003eNO\u003csub\u003e3\u003c/sub\u003e ([M\u0026thinsp;+\u0026thinsp;H]\u003csup\u003e+\u003c/sup\u003e) 326.1756, found 326.1755 .\u003c/p\u003e \u003cp\u003e \u003cb\u003e(\u003c/b\u003e \u003cspan type=\"BoldItalic\" class=\"BoldItalic\" name=\"Emphasis\"\u003eE\u003c/span\u003e \u003cb\u003e)-Ethyl 2-((cyclohexylamino)methyl)-3-(4-methoxyphenyl)acrylate (3m, C\u003c/b\u003e \u003csub\u003e \u003cb\u003e19\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eH\u003c/b\u003e \u003csub\u003e \u003cb\u003e27\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eNO\u003c/b\u003e \u003csub\u003e \u003cb\u003e3\u003c/b\u003e \u003c/sub\u003e \u003cb\u003e)\u003c/b\u003e: 85.5 mg; yield 75%; viscous oil; \u003cem\u003eR\u003c/em\u003e\u003csub\u003e\u003cem\u003ef\u003c/em\u003e\u003c/sub\u003e = 0.47 (EA: Hexane\u0026thinsp;=\u0026thinsp;1: 10) \u003csup\u003e1\u003c/sup\u003eH NMR (500 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) \u003cem\u003eδ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.67 (s, 1H), 7.44 (d, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;8.7 Hz, 2H), 6.84 (d, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;8.7 Hz, 2H), 4.19 (q, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 Hz, 2H), 3.75 (s, 3H), 3.54 (s, 2H), 2.46\u0026ndash;2.34 (m, 1H), 1.83\u0026ndash;1.46 (m, 4H), 1.26 (t, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 Hz, 3H), 1.24\u0026ndash;1.02 (m, 6H). \u003csup\u003e13\u003c/sup\u003eC NMR (151 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) \u003cem\u003eδ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;168.2, 160.0, 141.3, 131.3, 128.7, 127.6, 113.8, 60.6, 56.7, 55.1, 43.2, 33.1, 26.0, 24.8, 14.2 ppm. HRMS (ESI): \u003cem\u003em/z\u003c/em\u003e calcd for C\u003csub\u003e19\u003c/sub\u003eH\u003csub\u003e28\u003c/sub\u003eNO\u003csub\u003e3\u003c/sub\u003e ([M\u0026thinsp;+\u0026thinsp;H]\u003csup\u003e+\u003c/sup\u003e) 318.2069, found 318.2068.\u003c/p\u003e \u003cp\u003e \u003cb\u003e(\u003c/b\u003e \u003cspan type=\"BoldItalic\" class=\"BoldItalic\" name=\"Emphasis\"\u003eZ\u003c/span\u003e \u003cb\u003e)-2-((Benzylamino)methyl)-3-phenylacrylonitrile (3n, C\u003c/b\u003e \u003csub\u003e \u003cb\u003e17\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eH\u003c/b\u003e \u003csub\u003e \u003cb\u003e16\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eN\u003c/b\u003e \u003csub\u003e \u003cb\u003e2\u003c/b\u003e \u003c/sub\u003e \u003cb\u003e)\u003c/b\u003e: 217.1 mg; yield 88%; viscous oil; \u003cem\u003eR\u003c/em\u003e\u003csub\u003e\u003cem\u003ef\u003c/em\u003e\u003c/sub\u003e = 0.50 (EA: Hexane\u0026thinsp;=\u0026thinsp;1: 20). \u003csup\u003e1\u003c/sup\u003eH NMR (400 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) δ 7.79\u0026ndash;7.71 (m, 2H), 7.46\u0026ndash;7.24 (m, 8H), 7.08 (s, 1H), 3.85 (s, 2H), 3.57 (s, 2H). \u003csup\u003e13\u003c/sup\u003eC NMR (101 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) δ\u0026thinsp;=\u0026thinsp;144.5, 133.1, 130.3, 128.9, 128.8, 128.7, 128.5, 128.2, 127.3, 118.3, 109.6, 52.4, 51.9. HRMS (ESI): \u003cem\u003em/z\u003c/em\u003e calcd for C\u003csub\u003e17\u003c/sub\u003eH\u003csub\u003e17\u003c/sub\u003eN\u003csub\u003e2\u003c/sub\u003e ([M\u0026thinsp;+\u0026thinsp;H]\u003csup\u003e+\u003c/sup\u003e) 249.1392, found 249.1396.\u003c/p\u003e \u003cp\u003e \u003cb\u003e(\u003c/b\u003e \u003cspan type=\"BoldItalic\" class=\"BoldItalic\" name=\"Emphasis\"\u003eZ\u003c/span\u003e \u003cb\u003e)-2-((Cyclohexylamino)methyl)-3-phenylacrylonitrile (3o, C\u003c/b\u003e \u003csub\u003e \u003cb\u003e16\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eH\u003c/b\u003e \u003csub\u003e \u003cb\u003e20\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eN\u003c/b\u003e \u003csub\u003e \u003cb\u003e2\u003c/b\u003e \u003c/sub\u003e \u003cb\u003e)\u003c/b\u003e: 101.4 mg; yield 85%; viscous oil; \u003cem\u003eR\u003c/em\u003e\u003csub\u003e\u003cem\u003ef\u003c/em\u003e\u003c/sub\u003e = 0.48 (EA: Hexane\u0026thinsp;=\u0026thinsp;1: 10) \u003csup\u003e1\u003c/sup\u003eH NMR (500 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) \u003cem\u003eδ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.83\u0026ndash;7.65 (m, 2H), 7.48\u0026ndash;7.31 (m, 3H), 7.10 (d, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;4.4 Hz, 1H), 3.59\u0026ndash;3.52 (m, 2H), 2.58\u0026ndash;2.42 (m, 1H), 1.98\u0026ndash;1.51 (m, 6H), 1.38\u0026ndash;1.03 (m, 4H). \u003csup\u003e13\u003c/sup\u003eC NMR (126 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) \u003cem\u003eδ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;143.2, 133.2, 129.8, 128.5, 128.5, 118.2, 110.8, 55.0, 50.3, 33.1, 25.7, 24.5 ppm. HRMS (ESI): \u003cem\u003em/z\u003c/em\u003e calcd for C\u003csub\u003e16\u003c/sub\u003eH\u003csub\u003e21\u003c/sub\u003eN\u003csub\u003e2\u003c/sub\u003e ([M\u0026thinsp;+\u0026thinsp;H]\u003csup\u003e+\u003c/sup\u003e) 241.1705, found 241.1709.\u003c/p\u003e \u003cp\u003e \u003cb\u003e(\u003c/b\u003e \u003cspan type=\"BoldItalic\" class=\"BoldItalic\" name=\"Emphasis\"\u003eE\u003c/span\u003e \u003cb\u003e)-Ethyl2-((3-(2-oxoazepan-1-yl)propylamino)methyl)-3-phenylacrylate (4, C\u003c/b\u003e \u003csub\u003e \u003cb\u003e21\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eH\u003c/b\u003e \u003csub\u003e \u003cb\u003e30\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eN\u003c/b\u003e \u003csub\u003e \u003cb\u003e2\u003c/b\u003e \u003c/sub\u003e \u003cb\u003eO\u003c/b\u003e \u003csub\u003e \u003cb\u003e3\u003c/b\u003e \u003c/sub\u003e \u003cb\u003e)\u003c/b\u003e: 340.2 mg; yield 95%; viscous oil; \u003cem\u003eR\u003c/em\u003e\u003csub\u003e\u003cem\u003ef\u003c/em\u003e\u003c/sub\u003e = 0.9 (Acetone: Hexane\u0026thinsp;=\u0026thinsp;1: 2). \u003csup\u003e1\u003c/sup\u003eH NMR (400 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) δ 7.84 (s, 1H), 7.48\u0026ndash;7.31 (m, 5H), 4.30 (q, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 Hz, 2H), 3.64 (s, 2H), 3.44 (br s, 1H), 3.40 (t, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 Hz, 2H), 3.33\u0026ndash;3.29 (m, 2H), 2.62 (t, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 Hz, 2H), 2.53\u0026ndash;2.47 (m, 2H), 1.76\u0026ndash;1.57 (m, 8H), 1.36 (t, \u003cem\u003eJ\u003c/em\u003e\u0026thinsp;=\u0026thinsp;7.1 Hz, 3H). \u003csup\u003e13\u003c/sup\u003eC NMR (126 MHz, CDCl\u003csub\u003e3\u003c/sub\u003e) δ\u0026thinsp;=\u0026thinsp;175.9, 167.7, 142.1, 134.9, 129.9, 129.3, 128.7, 128.4, 60.9, 49.5, 46.1, 45.8, 45.2, 37.0, 29.8, 28.5, 27.7, 23.3, 14.1 ppm. HRMS (ESI): \u003cem\u003em/z\u003c/em\u003e calcd for C\u003csub\u003e16\u003c/sub\u003eH\u003csub\u003e21\u003c/sub\u003eN\u003csub\u003e2\u003c/sub\u003e ([M\u0026thinsp;+\u0026thinsp;H]\u003csup\u003e+\u003c/sup\u003e) 359.2335, found 359.2337.\u003c/p\u003e"},{"header":"Declarations","content":"\u003ch2\u003eAcknowledgements\u003c/h2\u003e \u003cp\u003eS.T.K. thank the Ministry of Tribal Affairs (India) for the award of fellowships. For FT-NMR (both proton and carbon) as well as HRMS data, SAIF- CSIR- Central Drugs Research Institute (CDRI), Lucknow (India) was very helpful and provided all the necessary data.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eBaylis AB, Hillman MED (1972) German Patent 2155113\u003c/li\u003e\n\u003cli\u003eBaylis AB, Hillman MED (1972) Chem. Abstr 77:34174q\u003c/li\u003e\n\u003cli\u003eDrewes SE, Roos GHP (1988) Tetrahedron 44:4653\u003c/li\u003e\n\u003cli\u003eBasavaiah D, Rao PD, Hyma RS (1996) Tetrahedron 52:8001\u003c/li\u003e\n\u003cli\u003eBasavaiah D, Jaganmohan Rao A, Satyanarayana T (2003) Chem Rev 103:811\u003c/li\u003e\n\u003cli\u003eHoffmann HMR, Rae J (1985) Angew Chemie Int Ed Engl 24:94\u003c/li\u003e\n\u003cli\u003eKim JN, Lee KY (2002) Curr Org Chem 6:627\u003c/li\u003e\n\u003cli\u003eBasavaiah D, Reddy RM, Kumaragurubaran N, Sharada DS (2002) Tetrahedron 58:3693\u003c/li\u003e\n\u003cli\u003eBasavaiah D, Satyanarayana T (2002) Tetrahedron Lett 43:4301\u003c/li\u003e\n\u003cli\u003eKaye PT, Nocanda XW (2002) J Chem Soc Perkin Trans 1:1318\u003c/li\u003e\n\u003cli\u003eKim JN, Kim HS, Gong JH, Chung YM (2001) Tetrahedron Lett 42:8341\u003c/li\u003e\n\u003cli\u003eKaye PT, Nocanda XW (2000) J Chem Soc Perkin Trans 1:1331\u003c/li\u003e\n\u003cli\u003eBasavaiah D, Sreenivasulu B, Rao JS (2001) Tetrahedron Lett 42:1147\u003c/li\u003e\n\u003cli\u003eAlcaide B, Almendros P, Aragoncillo C (1999) Tetrahedron Lett 40:7537\u003c/li\u003e\n\u003cli\u003eFranck X, Figad\u0026egrave;re B (2002) Tetrahedron Lett 43:1449\u003c/li\u003e\n\u003cli\u003eIwabuchi Y, Sugihara T, Esumi T, Hatakeyama S (2001) Tetrahedron Lett 42:7867\u003c/li\u003e\n\u003cli\u003eIwabuchi Y, Furukawa M, Esumi T, Hatakeyama S (2001) Chem Commun 2030\u003c/li\u003e\n\u003cli\u003eMateus CR, Feltrin MP, Costa AM, Coelho F, Almeida WP, Jauch J (2001) Synlett 87\u003c/li\u003e\n\u003cli\u003eReiser U, Jauch J (2001) Synlett 90\u003c/li\u003e\n\u003cli\u003eJauch J (2000) Angew Chem Int Ed 39:2764\u003c/li\u003e\n\u003cli\u003eGenski T, Taylor RJK (2002) Tetrahedron Lett 43:3573\u003c/li\u003e\n\u003cli\u003eSammelson RE, Gurusinghe CD, Kurth JM, Olmstead MM (2002) J Org Chem 67:86\u003c/li\u003e\n\u003cli\u003eCiclosi M, Fava C, Galeazzi R, Orena M, Sepulveda-Arques J (2002) Tetrahedron Lett 43:2119\u003c/li\u003e\n\u003cli\u003eHoffmann HMR, Rabe J (1984) Helv. 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(1987) Advances in Heterocyclic Chemistry Katrizky AR Ed Academic Press Inc New York Chap. 42, 83.\u003c/li\u003e\n\u003cli\u003eKim JN, Kim HJ, Gong JH, Im YJ (2001) Bull Korean Chem Soc 22:1053\u003c/li\u003e\n\u003cli\u003eBuchholz R, Hoffmann HMR (1991) Helv Chim Acta 74:1213\u003c/li\u003e\n\u003cli\u003eRajesh S, Banerji B, Iqbal J (2002) J Org Chem 67:7852 And references cited therein.\u003c/li\u003e\n\u003cli\u003eCiganek E (1997) In Organic Reactions, Paquette LA Ed Wiley New York 51:201\u003c/li\u003e\n\u003cli\u003eBasavaiah D, Kumaragurubaran N, Sharada DS (2001) Tetrahedron Lett 42:85\u003c/li\u003e\n\u003cli\u003eYang KS, Chen K (2000) Org Lett 2:729\u003c/li\u003e\n\u003cli\u003eChamakh A, Amri H (1998) Tetrahedron Lett 39:375\u003c/li\u003e\n\u003cli\u003eBasavaiah D, Kumaragurubaran N (2001) Tetrahedron Lett 42:477 and further references cited therein.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Schemes","content":"\u003cp\u003eSchemes 1 and 2 are available in the Supplementary Files section.\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"monatshefte-fur-chemie-chemical-monthly","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"mccm","sideBox":"Learn more about [Monatshefte für Chemie - Chemical Monthly](https://www.springer.com/journal/706)","snPcode":"706","submissionUrl":"https://www.editorialmanager.com/mccm/","title":"Monatshefte für Chemie - Chemical Monthly","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"Baylis-Hillman acetates, Amines, Solvent-free, Nucleophilic substitutions, DBU","lastPublishedDoi":"10.21203/rs.3.rs-2840001/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-2840001/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eA simple, new and solvent free route to the regioselective and stereoselective synthesis of (\u003cem\u003eE\u003c/em\u003e)- and (\u003cem\u003eZ\u003c/em\u003e)- allylamines has been achieved by the reaction of Baylis-Hillman acetates with various nitrogen nucleophiles in the presence of 1,8-diazabicyclo(5.4.0)undec-7-ene (DBU). This method requires very short reaction time and accomplished by S\u003csub\u003eN\u003c/sub\u003e2ʹ nucleophilic substitution pathway.\u003c/p\u003e","manuscriptTitle":"Synthesis of allylamines from Baylis-Hillman acetates using DBU under solvent free condition","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2023-05-02 04:45:53","doi":"10.21203/rs.3.rs-2840001/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"reviewerAgreed","content":"","date":"2023-04-27T08:14:02+00:00","index":0,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2023-04-27T07:35:37+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2023-04-24T04:16:52+00:00","index":"","fulltext":""},{"type":"submitted","content":"Monatshefte für Chemie - Chemical Monthly","date":"2023-04-21T07:57:37+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"monatshefte-fur-chemie-chemical-monthly","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"mccm","sideBox":"Learn more about [Monatshefte für Chemie - Chemical Monthly](https://www.springer.com/journal/706)","snPcode":"706","submissionUrl":"https://www.editorialmanager.com/mccm/","title":"Monatshefte für Chemie - Chemical Monthly","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false}}],"origin":"","ownerIdentity":"887d0855-574d-4ec9-a1c0-9bb68ab355bf","owner":[],"postedDate":"May 2nd, 2023","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[],"tags":[],"updatedAt":"2023-10-16T21:53:44+00:00","versionOfRecord":{"articleIdentity":"rs-2840001","link":"https://doi.org/10.1007/s00706-023-03095-y","journal":{"identity":"monatshefte-fur-chemie-chemical-monthly","isVorOnly":false,"title":"Monatshefte für Chemie - Chemical Monthly"},"publishedOn":"2023-06-26 21:27:58","publishedOnDateReadable":"June 26th, 2023"},"versionCreatedAt":"2023-05-02 04:45:53","video":"","vorDoi":"10.1007/s00706-023-03095-y","vorDoiUrl":"https://doi.org/10.1007/s00706-023-03095-y","workflowStages":[]},"version":"v1","identity":"rs-2840001","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-2840001","identity":"rs-2840001","version":["v1"]},"buildId":"7rjqhiLT3MXkJMwkYKINL","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}