TISSLET Tissues-based Learning Estimation for Transcriptomics

Abstract In the context of multi-omics data analytics for various diseases, transcriptome-wide association studies leveraging genetically predicted gene expression hold promise for identifying novel regions linked to complex traits. However, existing methods for multi-tissue gene expression prediction often fail to account for tissue-tissue expression interactions, limiting their accuracy and effectiveness. This research addresses the challenge of predicting gene expression across multiple tissues by incorporating tissue-tissue expression correlations based on a nonlinear multivariate model. Our findings demonstrate that this model excels in estimating tissue-tissue interactions and accurately predicting missing data. These results have significant implications for multi-omics data analytics and transcriptome-wide association studies, suggesting a novel approach for identifying regions associated with complex traits. Competing Interest Statement The authors have declared no competing interest.