Straightforward chemical desymmetrisation of cis-(±)-4-O-protected-cyclopent-2-enol using resolving agents on column chromatography

A simple and efficient procedure for the separation of cis-(+)- and cis-(−)-4- O -protected-cyclopent-2-enol, from the corresponding racemic mixture as starting material and using resolving agents, is described. The separation of diasteroisomers was accomplished by flash silica gel column chromatography. The enantiomers cis-(+)- and cis-(−)- of 4- O -protected-cyclopent-2-enol were obtained, in enantiomeric pure form, after elimination of the resolving agents.