Connexin 43 and Gynecological Diseases

The normal and abnormal expression of connexin play a direct role in the function of cell,tissue,and organ,whereas connexin 43 is the most important gap junction protein.The expression of connexin 43 is increased in uterine tissues,as a low-impedance channel for uterine intermuscular cell contraction.Gap junction channels are subject to the penetration of ions,ensuring the metabolism and behavioral coordination of uterine muscular cell populations.The abnormal expression of connexin 43 is closely associated with the occurrence and progress of uterine myoma,endometriosis,cervical cancer,and other gynecological disorders.