Relationship between fibrinogen/albumin ratio and early renal damage markers in patients with hypertension

Abstract Aim:To investigate the relationship between fibrinogen/albumin ratio (FAR) and early renal damage in hypertensive patients.Patients & methods:A retrospective study included 626 patients with hypertension, grouped according to the FAR tertiles and the presence or absence of early renal impairment. Early renal damage indicators[Serum cystatin c and β2 microglobulin] were detected in each group, and the differences between groups were compared, and the factors affecting early renal damage indicators were analyzed.Results:Serum cystatin c(CysC) and β2 microglobulin(β2-MG) levels in patients increased with FAR. In the renal impairment group, the fibrinogen and FAR were significantly increased, and serum albumin was decreased. FAR was positively correlated with β2-MG and CysC. Regression analysis showed that FAR level was a factor affecting blood β2-MG(β=6.632, p＜0.001)and CysC(β=1.991, p＜0.001).Conclusion:Elevated FAR is an independent risk factor for early renal damage in hypertensive patients