Increased chromium and molybdenum blood levels after minimally-invasive repair of pectus excavatum

Increased chromium and molybdenum blood levels after minimally-invasive repair of pectus excavatum | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Increased chromium and molybdenum blood levels after minimally-invasive repair of pectus excavatum Michele Torre, Luca Genova Gaia, Federica Lena, Maria Grazia Calevo, and 4 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7918550/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 09 Feb, 2026 Read the published version in Pediatric Surgery International → Version 1 posted 9 You are reading this latest preprint version Abstract Objectives Minimally Invasive Repair of Pectus Excavatum (MIRPE) is the most popular technique to repair pectus excavatum in young patients. One or more metallic bars are inserted and maintained for at least 2–3 years. Few reports about possible metal release in these patients were published recently. The study aimed to search for an increase in blood metal levels in patients after MIRPE and to investigate if surgical details (number of bars and stabilizers) were correlated with metal release. Methods We have prospectively studied blood levels of chromium, nickel, molybdenum and manganese before bar implant in a group of patients undergoing MIRPE between 2017 and 2019 and, in the same patients, at the moment of bar removals between 2020 and 2022. All our patients had the same stainless-steel bar. Blood samples were analysed using inductively coupled plasma mass spectrometry. Main results We enrolled a total of 53 (10 females) patients. Median age at MIRPE was 15.4 years. After a bar maintenance median time of 3.1 years, we found significantly (p < .05) higher mean levels of chromium (2.43 versus 0.52 µg/l) and molybdenum (1.87 versus 0.35 µg/l), and higher mean levels of nickel (4.24 versus 80.80 µg/l) and manganese (12.69 versus 19.81 µg/l) without statistical significance. No differences were found regarding the number of bars, stabilizers implanted or gender. No patients had clinical symptoms of metallosis. Conclusions We demonstrated that metal blood levels increase in patients with retrosternal bars after MIRPE. Clinical implications of our finding are still unknown. thoracic surgery pediatric surgery pectus excavatum minimally invasive surgery blood metal levels Introduction Minimally Invasive Repair of Pectus Excavatum (MIRPE), also known as the Nuss procedure, involves the placement of one or more metal bars inside the chest, to correct a congenital deformity called pectus excavatum, where the chest appears sunken. The metal bar used in MIRPE is typically made of surgical stainless steel or titanium. Several reports have demonstrated the effectiveness and safety of MIRPE, with overall excellent short and long-term outcomes [ 1 ] [ 2 ] and immediate improvement of the chest wall morphology. The procedure requires that the metal bars have to be secured to the rib cage and between themselves and one or more metal stabilizers are usually put in place for this purpose. Bars and stabilizers are typically removed after three years from the positioning, when the chest wall is permanently remodeled. Despite their temporariness, metal devices could be responsible for the development of side effects such as irritative symptoms. Elevated trace metal levels, in particular nickel and chromium, have been found after MIRPE at bar removal [ 3 ] [ 4 ]. Furthermore, Fortmann et al [ 5 ] pointed out that elevated blood nickel levels can persist for 30 months after the bar removal. Several studies report erosion and dissemination of the components of metallic prosthesis in the body in orthopedic surgery, however clinical consequences remain unclear [ 6 ] [ 7 ]. In general, toxic action of metals is correlated to the oxidative stress of the subject and the damage level is difficult to predict, therefore increased trace metals levels could present with a wide variety of signs and symptoms, from absence of symptoms to local effects to systemic consequences. Furthermore, it must be put in evidence that studies are discouraged by the technical issues encountered in accurately analyzing trace metal levels by inductively coupled plasma mass spectrometry (ICP-MS), a technique that is not commonly available in clinical laboratories. Considering the high incidence of pectus excavatum [ 8 ] and the popularity of MIRPE, increasing the available data on possible complications and side effects is crucial for improving patient outcomes and safety. The aim of this prospective, longitudinal, observational cohort study was to assess any differences in blood trace metal levels as a consequence of MIRPE by measuring metals in patients' blood longitudinally at the time of implantation and at the time of bar removal. Materials and Methods The study included 54 patients undergoing MIRPE between 2017 and 2020 and consequent bar removal procedures between 2020 and 2022 at Giannina Gaslini Institute, a pediatric tertiary care institution. The study was approved by the institutional Internal Review Board (IRB protocol number 0015221/20) and received ethical approval (protocol number MT/IGG01/2015). For each surgical procedure a detailed written and oral informed consent was obtained by the patient or by the person or people holding parental rights. All patients received the same implanted metal devices that were all stainless steel manufactured by Intrauma (Intrauma, Torino, Italy). Chemical composition (ISO 5832-1:2016) is reported in Table 1 . Bars and stabilizers are made of the same composition. Table 1 Intrauma (Intrauma, Torino, Italy) stainless steel chemical composition for bars and stabilizers; ISO 5832-1:2016 Element Mass fraction % Carbon 0.030 max Silicon 1.0 max Manganese 2.0 max Phosphorus 0.025 max Sulfur 0.010 max Nitrogen 0.10 max Chromium 17.0 to 19.0 max Molybdenum 2.25 to 3.00 Nickel 13.0 to 15.0 Copper 0.50 max Iron Balance Allergies to metals or other substances were investigated in patients and in their families. In patients with positive history of metal reactions a different type of device was chosen. Exclusion criteria included: differences in chemical composition of the bar, contamination of blood sample, absence of follow up after MIRPE, patient with positive history of metals allergy or adverse reaction. MIRPE was performed via right thoracoscopy. According to patient characteristics and age, one or more bars were inserted. In order to stabilize the bar, one or more metal stabilizers were used. Follow up was regularly scheduled at our Institute. For each patient blood metals were evaluated before the implant, and at bar removal. In particular, before starting each surgical procedure and after general anaesthesia induction, a blood sample was obtained via peripheral venous access using a syringe without a needle and then collected in metal-free tubes (Vacuette Greiner Bio-One International) after discarding the first 3 ml, to limit any possible contamination. Blood samples were stored at -30°C until they were shipped to the reference laboratory (Haematology and Rare Disease Department, United Hospitals Villa Sofia-Cervello Hospital, Palermo, Italy) for analysis. Metal quantification was performed by inductively coupled plasma mass spectrometry (ICP-MS -Thermo Scientific iCAP TQe) equipped with a collision cell. Using minor modification of the previously published method [ 3 ]. All chemicals used for the ICP-MS analysis were of ultrapure grade. Nitric Acid 65% w/w and hydrogen peroxide 30% were purchased from J.T.Baker. Ultra-pure water (resistivity of 18.2 MΏ) was obtained by Nano-pure Diamont-Bearnstead. Working standard solutions for each element were prepared on a daily basis using high-density polyethylene bottles by stepwise dilution of the multi-element stock standard solution (1000 ± 5 g mL − 1 ) (DBH, Merck or CPI International) in a solution of HNO 3 1%. Blood samples were digested and mineralized using a microwave oven (CEM, Italy) with a high-pressure rotor. A 2 ml aliquot of blood was transferred inside quartz vessels and treated with 3 mL of HNO 3 (69%), 2 mL of H 2 O 2 (30%) and 100 µL of a solution containing Au at 100 ng/L. The instrumental conditions used for the microwave digestion were: 2 min at 100°C, P = 500 PSI, 1 min at 150°C, P = 500 PSI and 5 min at 200°C P = 500 PSI. Optimization was performed by using a a 1 µg L − 1 solution of 7 Li, 59 Co, 115 In, 140 Ce and 238 U (in HNO 3 1%). Moreover, the 140 Ce 16 O + / 140 Ce + ratio was used to check the level of oxide ions in the plasma and instrumental parameters such as RF power and carrier gas flow were optimized and the level of doubly charged ion was monitored by means of the signal Ba 2+/ Ba + . In order to minimize polyatomic interferences, such as the chromium signal at m/z 53 that is affected by 40 Ar 13 C + and 37 Cl 16 O + , or the nickel signal at m/z 58 that is affected by 42 Ca 16 O + . A collision cell was used. The formation of interfering polyatomic species was monitored by evaluating the ratios CeO/Ce and Ba 2+ /Ba + maintained less than 3% by setting of the voltages applied to the instrument lenses. The instrumental parameters used are listed in Table 1 . A solution of HNO 3 1M was run during the analysis to guarantee negligible memory effect. Blank samples were also analysed and subtracted from each determination. Each solution was measured in triplicate and ICP-MS analyses were carried out with a classical external calibration approach from 0.05 to 500 ng/ mL for each investigated element using 89Y (50 ng/ mL) as an internal standard to compensate for any signal instability, all data in cps were normalised to the internal standard. The operating conditions are shown in Table 2 . Table 2 Parameters and operating conditions for the ICP-MS instrument Descriptive statistics were generated. Data were expressed as mean and standard deviation, as median and range for continuous variables and as absolute or relative frequencies for categorical variables. Data distribution was analysed using the Kolmogorov-Smirnov test and non-parametric statistics were considered. The paired Wilcoxon test was used to compare the trace metals levels present before inserting the bars and when removing the bars. Differences between groups were evaluated using the Mann-Whitney test for continuous variables and χ2 or Fisher's exact test for categorical variables. The Spearman correlation analysis was used to observe the correlations between interval time from bar placement to removal and increase of the trace metals levels A P-value < 0.05 was considered as statistically significant, all P values were based on two-tailed tests. Statistical analyses were performed using SPSSS for Windows version 20 (SPSS Inc, Chicago, Il, USA). The reference values for blood metal thresholds provided by the Italian National Institute of Health (Istituto Superiore di Sanità) were applied [ 9 ]. Results Fifty-four patients were enrolled: 46 boys (85.2%) and 8 girls (14.8%). Mean age was 14.9 years (SD ± 3.82) at first procedure and 18.3 years (SD ± 3.27) at bar removal. The median time elapsed from bar placement to removal was 3.16 years, (range 2.15–3.81 years). One patient was excluded from the analysis because of a very high Nickel value (> 10000 µg/l) recorded at the time of bar placement. The same patient had values slightly above the limit of normal at bar removal, so it was decided to consider the first sample as contaminated and to exclude the patient. For each metal of interest, differences between mean value of trace metal levels before MIRPE and at bar removal were calculated. Results are summarized in Table 3 . Chromium and molybdenum mean values were significantly increased (from 0,52 ± 0,43 to 2,43 ± 9,57 µg/l; p < 0.001 and from 0,35 ± 0,39 to 1,87 ± 1,29 µg/l; p < 0.001 respectively), without any correlation with interval time from placement to removal. Nickel and manganese mean values were also increased, but the differences were not statistically significant. For each metal of interest, the number of patients with value above the reference threshold before and after metal devices placement were compared. As regards chromium, the patients with value above the limits pre MIRPE were 47.2% while post MIRPE 62.3%, with no significant increase (p > 0.05). No significant differences were observed also for manganese, molybdenum and nickel. Table 3 Mean metal values pre and post MIRPE devices Patients Pre MIRPE mean ± sd Post MIRPE mean ± sd p value Chromium 53 0,52 ± 0,43 2,43 ± 9,57 < 0.001 Manganese 53 12,69 ± 7,84 19,81 ± 45,97 0.26 Molybdenum 53 0,35 ± 0,39 1,87 ± 1,29 < 0.001 Nickel 53 4,24 ± 12,50 80,80 ± 305,28 0.31 MIRPE Minimally Invasive Repair of Pectus Excavatum Patients with more than one bar did not display higher level of metals after MIRPE compared to those with one bar only (Table 4 ). Table 4 Metals values according to number of bars N° bars = 1 N = 33 N° bars > 1 N = 20 p value mean ± SD mean ± SD Chromium PRE 0.56 ± 0.44 0.44 ± 0. 39 0.32 Chromium POST 3.33 ± 12.07 0.93 ± 1.09 0.38 Manganese PRE 12.05 ± 8 13.76 ± 7.64 0.44 Manganese POST 24.15 ± 58.09 12.65 ± 3.72 0.38 Molybdenum PRE 0.23 ± 0.35 0.54 ± 0.39 0.001 Molybdenum POST 1.92 ± 1.46 1.81 ± 1 0.77 Nickel PRE 3.06 ± 5.65 6.18 ± 19.17 0.38 Nickel POST 72.62 ± 231.24 94.30 ± 405.83 0.81 Considering the number of stabilizers, no significant differences were found between the number of stabilizers and differences between blood levels. No significant difference based on age at first procedure or time before the second procedure could be found. A higher mean value of nickel among female patients could be observed although the analysis of differences between male and female subjects didn`t reveal any significative statistical difference. Discussion In recent years, interest in studying the correlation between metal surgical implants and metal levels in biological tissues has significantly grown. In particular, in orthopaedics, this issue has been widely discussed and studied for many years. Consumption and corrosion of prostheses metal components con result in tissue release of ions, particularly chromium and cobalt. Other materials such as titanium can also be released from such devices [ 10 ] [ 11 ]. This phenomenon can lead to severe local tissue reactions up to necrosis and potential systemic adverse effects due to dispersion into the bloodstream of ions. Peri-implant biological analyses can detect the presence of metals compatible with device composition and trace metals can also be found in tissues and organs far from the primary site [ 12 ] [ 13 ]. MIRPE technique was initially described by Nuss [ 14 ] and is nowadays considered as the gold standard for pectus excavatum repair and its popularity is increasing. Treated patients are in most cases young, which enhances the need in determining possible local and systemic impact of implanted metallic devices in a short and long term. Cundy and Kirby were the first to raise the attention to trace metal levels in the blood of patients undergoing MIRPE in 2012 [ 15 ] and described an increased serum chromium. Fortmann et al [ 4 ] found elevated metal values in various biological tissues, including plasma, urine, and peri-prosthetic tissue. In 2021 [ 3 ] we analysed blood metal levels in two groups of patients pre and post maintenance of bars and stabilizers and we found a significant increase in blood chromium values and a general upward trend in the metals studied. At the same time, stabilizers seemed to correlate to higher levels of blood of the metals, suggesting a release caused mainly by friction between the metal components. In the present paper, we performed a longitudinal evaluation in the same patient before and after bar and stabilizer maintenance, thus reducing one of the major biases of most previous studies, namely individual variability. We confirm that chromium concentrations increase in patients after MIRPE, both considering the percentage of patients above the threshold and considering the mean value pre- and post-surgical correction. Interestingly, differently from our previous findings, in this work we were not able to find any significant difference correlated to the number of stabilizers used. At least one stabilizer was always used in this population so it was not possible to perform analyses on patients without stabilizers to possibly confirm previous evidence. The clinical impact of metal release in patients after MIRPE has not been yet established. Systemic toxicity effects by metal release were never reported in PE population, to our knowledge. However, we cannot exclude potential general toxicity consequences in patients with such increased blood metal levels. Evaluating the potential risk of metal toxicity in patients operated for MIRPE, we have to consider that abnormal metal levels can be found in different biological tissues and for long time after MIRPE according to the studies of Fortmann. Also according to Seyrek and Akkus [ 16 ] the values of metals such as nickel have found to be increased even after devices removal, as demonstrated by studying hair samples. In our opinion, the results of our study enhance once more the need of further investigating the role of metal release in PE population. This is paramount, considering that pectus excavatum population is mainly composed by young and healthy patients, who are exposed to un unknown risk for a prolonged period. Moreover, it has been hypothesized that local irritative symptoms, such as local swelling, seroma, wound healing disorders, or pleural effusion, can be associated with metal release after MIRPE. These signs must be differentiated from metal allergy which seems to appear in 0.5–6.4% of MIRPE patients [ 17 ]. Interestingly, pre operative metal allergy testing doesn’t seem to be associated with a reduction in bar allergy symptoms [ 18 ]. Fortmann et al found an increased risk of irritative symptoms of the soft tissue and pleural effusion in patients with abnormal tissue metal levels. In contrast, none of the patients described in our study presented similar symptoms. Solutions to lowering the risk of metal release such as, for example, a titanium nitride coating apparently do not display any protective effect if compared with uncoated device placement [ 19 ]. The use of titanium bar instead of steel bars could be another attempt of reducing toxicity by metal release, however we do not have any data to support this at the present time. Differently from our previous study, in which different cohorts of patients were compared, in the present study we have analysed metal levels in the same cohort pre and post MIRPE, which represents the main point of strength. The number of patients, although higher than in other studies, remains the main limitation of this study as it cannot be excluded that results could be subjected to wider variations when considering a larger sample size. Another critical issue that should not be underestimated is the possible interference of external variables in the concentration of trace metals (e.g., diet, geographical area). Another limitation of this study is the use of reference values for the adult population. Conclusion Patients undergoing MIRPE displayed increased blood levels of chromium and molybdenum. At present, there was no correlation between blood levels and symptoms correlated with these findings in the short- and medium-term follow-up. However, a pathological role of these results cannot be ruled out with certainty. Although generally considered safe from the point of view of biocompatibility, future developments of MIRPE also depend on the evolution of materials. Abbreviations MIRPE, PE, ICP-MS. Declarations Conflict of interest: none declared. Author Contribution Michele Torre: Conceptualization; Writing—original draft; Supervision; Project Luca Genova Gaia: Conceptualization; Data curation; Writing—original draft. Federica Lena: Writing - original draft. Maria Grazia Calevo: Formal analysis; Methodology; Supervision; Writing—review & editing. Maria Raso: Formal analysis. Sebastiano Barco: Data curation. Francesca Di Gaudio: Formal analysis; Methodology; Supervision; Writing—review & editing. Giuliana Cangemi: Conceptualization; Methodology; Supervision; Writing—review & editingFrancesca Di Gaudio and Giuliana Cangemi contributed equally to this manuscript. Data Availability The data underlying this article will be shared on reasonable request to the corresponding author. References Jaroszewski DE, Ewais MAM, Chao CJ, Gotway MB, Lackey JJ, Myers KM et al (2016) Success of Minimally Invasive Pectus Excavatum Procedures (Modified Nuss) in Adult Patients (≥ 30 Years). Ann Thorac Surg. ;102(3):993–1003.Available from: http://dx.doi.org/10.1016/j.athoracsur.2016.03.105 Nuss D, Kelly RE (2008) Minimally Invasive Surgical Correction of Chest Wall Deformities in Children (Nuss Procedure). Adv Pediatr 55(1):395–410 Torre M, Genova Gaia L, Calevo MG, Wong M, Raso M, Barco S et al (2021) Blood metal levels after minimally invasive repair of pectus excavatum. Interact Cardiovasc Thorac Surg 33(1):76–81 Fortmann C, Göen T, Krüger M, Ure BM, Petersen C, Kübler JF (2017) Trace metal release after minimally-invasive repair of pectus excavatum. PLoS ONE 12(10):1–11 Fortmann C, Goeen T, Zinne N, Wiesner S, Ure BM, Petersen C et al (2022) Nickel contamination after minimally-invasive repair of pectus excavatum persists after bar removal. PLoS One. ;17(10 October):1–13. Available from: http://dx.doi.org/10.1371/journal.pone.0275567 Das KK, Reddy RC, Bagoji IB, Das S, Bagali S, Mullur L et al (2019) Primary concept of nickel toxicity - An overview. J Basic Clin Physiol Pharmacol 30(2):141–152 Murthy MK, Khandayataray P, Padhiary S, Samal D (2023) A review on chromium health hazards and molecular mechanism of chromium bioremediation. Rev Environ Health. ;38(3):461–78. Available from: https://doi.org/10.1515/reveh-2021-0139 Obermeyer RJ, Goretsky MJ (2012) Chest Wall Deformities in Pediatric Surgery. Surg Clin North Am. ;92(3):669–84. Available from: http://dx.doi.org/10.1016/j.suc.2012.03.001 Alimonti A, Bocca B, Mattei D, Pino A (2010) Biomonitoraggio della popolazione italiana per l’esposizione ai metalli: valori di riferimento 1990–2009. Rapp ISTISAN. ;8 Witzleb WC, Ziegler J, Krummenauer F, Neumeister V, Guenther KP (2006) Exposure to chromium, cobalt and molybdenum from metal-on-metal total hip replacement and hip resurfacing arthroplasty. Acta Orthop 77(5):697–705 Sunderman FW, Hopfer SM, Swift T, Rezuke WN, Ziebka L, Highman P et al (1989) Cobalt, chromium, and nickel concentrations in body fluids of patients with porous-coated knee or hip prostheses. J Orthop Res 7(3):307–315 Ho JH, Leikin JB, Dargan PI, Archer JRH, Wood DM, Brent J (2017) Metal-on-Metal Hip Joint Prostheses: a Retrospective Case Series Investigating the Association of Systemic Toxicity with Serum Cobalt and Chromium Concentrations. J Med Toxicol 13(4):321–328 Matusiewicz H (2014) Potential release of in vivo trace metals from metallic medical implants in the human body: From ions to nanoparticles - A systematic analytical review. Acta Biomater. ;10(6):2379–403. Available from: http://dx.doi.org/10.1016/j.actbio.2014.02.027 Nuss D, Kelly RE, Croitoru DP, Katz ME (1998) A 10-year review of a minimally invasive technique for the correction of pectus excavatum. J Pediatr Surg 33(4):545–552 Cundy TP, Kirby CP (2012) Serum metal levels after minimally invasive repair of pectus excavatum. J Pediatr Surg. ;47(8):1506–11. Available from: http://dx.doi.org/10.1016/j.jpedsurg.2012.02.005 Seyrek Y, Akkuş M (2021) A prospective study on long-term trace metal accumulation in hair: Is there any difference between minimally invasive repair of pectus excavatum and carinatum? J Pediatr Surg 56(12):2253–2257 Gałązka P, Leis K, Kroczek K, Baska A, Kazik J, Czajkowski R (2021) Metal allergy after the Nuss procedure for pectus excavatum: a review. Postep Dermatologii i Alergol 37(6):848–852 Ochoa B, Lai K, Eldredge RS, Viswanath V, Bae JO, Lee J, McMahon LE, Notrica DMPB (2024) Preoperative Metal Allergy Testing for Pectus Excavatum Repair Does Not Effectively Identify Patients Who Develop Metal bar Allergy. J Pediatr Surg May; 59(5):956–961 Fortmann C, Goen T, Wiesner S, Hegermann J, Kiblawi R, Dohna M et al (2023) Titanium nitride coating of pectus bar increases metal contamination after minimally-invasive repair of pectus excavatum. PLoS ONE 18(10 October):1–14 Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 09 Feb, 2026 Read the published version in Pediatric Surgery International → Version 1 posted Editorial decision: Revision requested 29 Dec, 2025 Reviews received at journal 29 Dec, 2025 Reviews received at journal 19 Dec, 2025 Reviewers agreed at journal 19 Dec, 2025 Reviewers agreed at journal 09 Dec, 2025 Reviewers invited by journal 27 Oct, 2025 Editor assigned by journal 25 Oct, 2025 Submission checks completed at journal 23 Oct, 2025 First submitted to journal 21 Oct, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7918550","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":537127010,"identity":"c05a801c-61fd-4fe1-acfc-edb1af965a67","order_by":0,"name":"Michele Torre","email":"","orcid":"","institution":"IRCCS Istituto Giannina Gaslini","correspondingAuthor":false,"prefix":"","firstName":"Michele","middleName":"","lastName":"Torre","suffix":""},{"id":537127011,"identity":"225fb62b-39fc-4ccf-b900-471c43a45eca","order_by":1,"name":"Luca Genova Gaia","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABAUlEQVRIiWNgGAWjYBACPhReAoMNkGRsPIBPCxualjSQlgYStDAwHAaT+LVIJD/8+KXijpzB8eMXPzyoOW+3tv0w0JYam2jcWtKMpWXOPDM2OJNTLJFw7HbytjOJQC3H0nIbcGrJYZCWbDucOLMhJ0Eige12stkBoBbGhsP4tDD/lvwH1NL/JvlHwr9zyWbnHxLUwib5seFwYr9E+jGJxLYDdmY3CNnC88zMmuHYYWN+iTdsFol9yQlmN4C2JODxCz978uObP2oOy7HxpwMZ3+zszc6nP3zwocYGpxYQYOYBUzwGIDIRrDIBj3IQYPwBptgfgEh7AopHwSgYBaNgBAIAEM5lFlu6fB0AAAAASUVORK5CYII=","orcid":"","institution":"IRCCS Istituto Giannina Gaslini","correspondingAuthor":true,"prefix":"","firstName":"Luca","middleName":"Genova","lastName":"Gaia","suffix":""},{"id":537127012,"identity":"8944d368-c7ba-485c-8237-ac6bc84f17ef","order_by":2,"name":"Federica Lena","email":"","orcid":"","institution":"IRCCS Istituto Giannina Gaslini","correspondingAuthor":false,"prefix":"","firstName":"Federica","middleName":"","lastName":"Lena","suffix":""},{"id":537127013,"identity":"3348c03f-dda7-484e-9ad1-917cba41f8c8","order_by":3,"name":"Maria Grazia Calevo","email":"","orcid":"","institution":"IRCCS Istituto Giannina Gaslini","correspondingAuthor":false,"prefix":"","firstName":"Maria","middleName":"Grazia","lastName":"Calevo","suffix":""},{"id":537127014,"identity":"4fb08555-da09-4e4c-88a2-3e03ab15692e","order_by":4,"name":"Maria Raso","email":"","orcid":"","institution":"Quality Control and Chemical Risk (CQRC), University of Palermo","correspondingAuthor":false,"prefix":"","firstName":"Maria","middleName":"","lastName":"Raso","suffix":""},{"id":537127015,"identity":"ea114f0b-a4c2-457f-85ce-e64f29abe066","order_by":5,"name":"Sebastiano Barco","email":"","orcid":"","institution":"IRCCS Istituto Giannina Gaslini","correspondingAuthor":false,"prefix":"","firstName":"Sebastiano","middleName":"","lastName":"Barco","suffix":""},{"id":537127016,"identity":"64cf412a-3596-44a2-93a3-41abb3fc1219","order_by":6,"name":"Francesca Gaudio","email":"","orcid":"","institution":"Quality Control and Chemical Risk (CQRC), University of Palermo","correspondingAuthor":false,"prefix":"","firstName":"Francesca","middleName":"","lastName":"Gaudio","suffix":""},{"id":537127017,"identity":"553644e1-c569-4dde-8326-edd52844f110","order_by":7,"name":"Giuliana Cangemi","email":"","orcid":"","institution":"IRCCS Istituto Giannina Gaslini","correspondingAuthor":false,"prefix":"","firstName":"Giuliana","middleName":"","lastName":"Cangemi","suffix":""}],"badges":[],"createdAt":"2025-10-22 08:24:49","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-7918550/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-7918550/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1007/s00383-026-06303-y","type":"published","date":"2026-02-09T15:59:24+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":95302697,"identity":"aad74ff1-64cf-4f64-b9fe-889881784fe9","added_by":"auto","created_at":"2025-11-06 13:52:56","extension":"docx","order_by":0,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":79661,"visible":true,"origin":"","legend":"","description":"","filename":"ManuscriptMIRPEandmetals2025.docx","url":"https://assets-eu.researchsquare.com/files/rs-7918550/v1/56e7d3c694c4e94f8b02a717.docx"},{"id":95302695,"identity":"5bc690c9-fa87-44aa-bffc-9832570bd939","added_by":"auto","created_at":"2025-11-06 13:52:56","extension":"json","order_by":1,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":9242,"visible":true,"origin":"","legend":"","description":"","filename":"95b61bae8c4147c18fb133a74b13427b.json","url":"https://assets-eu.researchsquare.com/files/rs-7918550/v1/9c34c7a5af77b2075c039aa9.json"},{"id":95302694,"identity":"e4564e01-d40e-43fa-9261-c9c55a206c20","added_by":"auto","created_at":"2025-11-06 13:52:56","extension":"xml","order_by":2,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":68204,"visible":true,"origin":"","legend":"","description":"","filename":"95b61bae8c4147c18fb133a74b13427b1enriched.xml","url":"https://assets-eu.researchsquare.com/files/rs-7918550/v1/18cdfcba9419d56ad767ad8a.xml"},{"id":95302700,"identity":"e385ff85-0906-49f6-b813-89c966982bea","added_by":"auto","created_at":"2025-11-06 13:52:56","extension":"emf","order_by":3,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":132612,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage1.emf","url":"https://assets-eu.researchsquare.com/files/rs-7918550/v1/5d419d5f602af1c56b4460ba.emf"},{"id":95302698,"identity":"15bf482e-7c26-43af-aa3e-e0e297ec4f11","added_by":"auto","created_at":"2025-11-06 13:52:56","extension":"png","order_by":4,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":119476,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-7918550/v1/a002782e74a4724488d6a4eb.png"},{"id":95302696,"identity":"7a9bc771-a44d-412b-a793-ae48037a3a6d","added_by":"auto","created_at":"2025-11-06 13:52:56","extension":"xml","order_by":5,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":65730,"visible":true,"origin":"","legend":"","description":"","filename":"95b61bae8c4147c18fb133a74b13427b1structuring.xml","url":"https://assets-eu.researchsquare.com/files/rs-7918550/v1/3b3c171034567950fffedbf4.xml"},{"id":95314835,"identity":"c8b26e9e-0f88-4160-8ab1-dac813e7113d","added_by":"auto","created_at":"2025-11-06 15:53:22","extension":"html","order_by":6,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":73434,"visible":true,"origin":"","legend":"","description":"","filename":"earlyproof.html","url":"https://assets-eu.researchsquare.com/files/rs-7918550/v1/521785bdbf1dbf549a5c6135.html"},{"id":102785575,"identity":"607138cf-3103-4572-815d-6d374c6eb87a","added_by":"auto","created_at":"2026-02-16 16:08:16","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":556312,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7918550/v1/7671e580-3e61-4fd9-9f27-f2f8cbcbf18b.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Increased chromium and molybdenum blood levels after minimally-invasive repair of pectus excavatum","fulltext":[{"header":"Introduction","content":"\u003cp\u003eMinimally Invasive Repair of Pectus Excavatum (MIRPE), also known as the Nuss procedure, involves the placement of one or more metal bars inside the chest, to correct a congenital deformity called pectus excavatum, where the chest appears sunken. The metal bar used in MIRPE is typically made of surgical stainless steel or titanium. Several reports have demonstrated the effectiveness and safety of MIRPE, with overall excellent short and long-term outcomes [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e] [\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e] and immediate improvement of the chest wall morphology. The procedure requires that the metal bars have to be secured to the rib cage and between themselves and one or more metal stabilizers are usually put in place for this purpose. Bars and stabilizers are typically removed after three years from the positioning, when the chest wall is permanently remodeled.\u003c/p\u003e\u003cp\u003eDespite their temporariness, metal devices could be responsible for the development of side effects such as irritative symptoms. Elevated trace metal levels, in particular nickel and chromium, have been found after MIRPE at bar removal [\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e] [\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e]. Furthermore, Fortmann et al [\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e] pointed out that elevated blood nickel levels can persist for 30 months after the bar removal.\u003c/p\u003e\u003cp\u003eSeveral studies report erosion and dissemination of the components of metallic prosthesis in the body in orthopedic surgery, however clinical consequences remain unclear [\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e] [\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e]. In general, toxic action of metals is correlated to the oxidative stress of the subject and the damage level is difficult to predict, therefore increased trace metals levels could present with a wide variety of signs and symptoms, from absence of symptoms to local effects to systemic consequences. Furthermore, it must be put in evidence that studies are discouraged by the technical issues encountered in accurately analyzing trace metal levels by inductively coupled plasma mass spectrometry (ICP-MS), a technique that is not commonly available in clinical laboratories.\u003c/p\u003e\u003cp\u003eConsidering the high incidence of pectus excavatum [\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e] and the popularity of MIRPE, increasing the available data on possible complications and side effects is crucial for improving patient outcomes and safety.\u003c/p\u003e\u003cp\u003eThe aim of this prospective, longitudinal, observational cohort study was to assess any differences in blood trace metal levels as a consequence of MIRPE by measuring metals in patients' blood longitudinally at the time of implantation and at the time of bar removal.\u003c/p\u003e"},{"header":"Materials and Methods","content":"\u003cp\u003eThe study included 54 patients undergoing MIRPE between 2017 and 2020 and consequent bar removal procedures between 2020 and 2022 at Giannina Gaslini Institute, a pediatric tertiary care institution.\u003c/p\u003e\n\u003cp\u003eThe study was approved by the institutional Internal Review Board (IRB protocol number 0015221/20) and received ethical approval (protocol number MT/IGG01/2015). For each surgical procedure a detailed written and oral informed consent was obtained by the patient or by the person or people holding parental rights.\u003c/p\u003e\n\u003cp\u003eAll patients received the same implanted metal devices that were all stainless steel manufactured by Intrauma (Intrauma, Torino, Italy). Chemical composition (ISO 5832-1:2016) is reported in Table \u003cspan class=\"InternalRef\"\u003e1\u003c/span\u003e. Bars and stabilizers are made of the same composition.\u003c/p\u003e\n\u003cp\u003e\u003c/p\u003e\n\u003ctable id=\"Tab1\" border=\"1\"\u003e\n \u003ccaption language=\"En\"\u003e\n \u003cdiv class=\"CaptionNumber\"\u003eTable 1\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003eIntrauma (Intrauma, Torino, Italy) stainless steel chemical composition for bars and stabilizers; ISO 5832-1:2016\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eElement\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eMass fraction %\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eCarbon\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.030 max\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eSilicon\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1.0 max\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eManganese\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2.0 max\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003ePhosphorus\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.025 max\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eSulfur\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.010 max\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNitrogen\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.10 max\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eChromium\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e17.0 to 19.0 max\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eMolybdenum\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2.25 to 3.00\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNickel\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e13.0 to 15.0\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eCopper\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.50 max\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eIron\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eBalance\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003c/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp\u003eAllergies to metals or other substances were investigated in patients and in their families. In patients with positive history of metal reactions a different type of device was chosen.\u003c/p\u003e\n\u003cp\u003eExclusion criteria included: differences in chemical composition of the bar, contamination of blood sample, absence of follow up after MIRPE, patient with positive history of metals allergy or adverse reaction.\u003c/p\u003e\n\u003cp\u003eMIRPE was performed via right thoracoscopy. According to patient characteristics and age, one or more bars were inserted. In order to stabilize the bar, one or more metal stabilizers were used.\u003c/p\u003e\n\u003cp\u003eFollow up was regularly scheduled at our Institute. For each patient blood metals were evaluated before the implant, and at bar removal. In particular, before starting each surgical procedure and after general anaesthesia induction, a blood sample was obtained via peripheral venous access using a syringe without a needle and then collected in metal-free tubes (Vacuette Greiner Bio-One International) after discarding the first 3 ml, to limit any possible contamination.\u003c/p\u003e\n\u003cp\u003eBlood samples were stored at -30\u0026deg;C until they were shipped to the reference laboratory (Haematology and Rare Disease Department, United Hospitals Villa Sofia-Cervello Hospital, Palermo, Italy) for analysis. Metal quantification was performed by inductively coupled plasma mass spectrometry (ICP-MS -Thermo Scientific iCAP TQe) equipped with a collision cell. Using minor modification of the previously published method [\u003cspan class=\"CitationRef\"\u003e3\u003c/span\u003e]. All chemicals used for the ICP-MS analysis were of ultrapure grade. Nitric Acid 65% w/w and hydrogen peroxide 30% were purchased from J.T.Baker. Ultra-pure water (resistivity of 18.2 MΏ) was obtained by Nano-pure Diamont-Bearnstead. Working standard solutions for each element were prepared on a daily basis using high-density polyethylene bottles by stepwise dilution of the multi-element stock standard solution (1000\u0026thinsp;\u0026plusmn;\u0026thinsp;5 g mL\u003csup\u003e\u0026minus;\u0026thinsp;1\u003c/sup\u003e) (DBH, Merck or CPI International) in a solution of HNO\u003csub\u003e3\u003c/sub\u003e 1%. Blood samples were digested and mineralized using a microwave oven (CEM, Italy) with a high-pressure rotor. A 2 ml aliquot of blood was transferred inside quartz vessels and treated with 3 mL of HNO\u003csub\u003e3\u003c/sub\u003e (69%), 2 mL of H\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e2\u003c/sub\u003e (30%) and 100 \u0026micro;L of a solution containing Au at 100 ng/L. The instrumental conditions used for the microwave digestion were: 2 min at 100\u0026deg;C, P\u0026thinsp;=\u0026thinsp;500 PSI, 1 min at 150\u0026deg;C, P\u0026thinsp;=\u0026thinsp;500 PSI and 5 min at 200\u0026deg;C P\u0026thinsp;=\u0026thinsp;500 PSI. Optimization was performed by using a a 1 \u0026micro;g L\u003csup\u003e\u0026minus;\u0026thinsp;1\u003c/sup\u003e solution of \u003csup\u003e7\u003c/sup\u003eLi, \u003csup\u003e59\u003c/sup\u003eCo, \u003csup\u003e115\u003c/sup\u003eIn, \u003csup\u003e140\u003c/sup\u003eCe and \u003csup\u003e238\u003c/sup\u003eU (in HNO\u003csub\u003e3\u003c/sub\u003e 1%). Moreover, the \u003csup\u003e140\u003c/sup\u003eCe\u003csup\u003e16\u003c/sup\u003eO\u003csup\u003e+\u003c/sup\u003e/\u003csup\u003e140\u003c/sup\u003eCe\u003csup\u003e+\u003c/sup\u003e ratio was used to check the level of oxide ions in the plasma and instrumental parameters such as RF power and carrier gas flow were optimized and the level of doubly charged ion was monitored by means of the signal Ba\u003csup\u003e2+/\u003c/sup\u003eBa\u003csup\u003e+\u003c/sup\u003e. In order to minimize polyatomic interferences, such as the chromium signal at m/z 53 that is affected by \u003csup\u003e40\u003c/sup\u003eAr\u003csup\u003e13\u003c/sup\u003eC\u003csup\u003e+\u003c/sup\u003e and \u003csup\u003e37\u003c/sup\u003eCl\u003csup\u003e16\u003c/sup\u003eO\u003csup\u003e+\u003c/sup\u003e, or the nickel signal at m/z 58 that is affected by \u003csup\u003e42\u003c/sup\u003eCa\u003csup\u003e16\u003c/sup\u003eO\u003csup\u003e+\u003c/sup\u003e. A collision cell was used. The formation of interfering polyatomic species was monitored by evaluating the ratios CeO/Ce and Ba\u003csup\u003e2+\u003c/sup\u003e/Ba\u003csup\u003e+\u003c/sup\u003e maintained less than 3% by setting of the voltages applied to the instrument lenses. The instrumental parameters used are listed in Table \u003cspan class=\"InternalRef\"\u003e1\u003c/span\u003e. A solution of HNO\u003csub\u003e3\u003c/sub\u003e 1M was run during the analysis to guarantee negligible memory effect. Blank samples were also analysed and subtracted from each determination. Each solution was measured in triplicate and ICP-MS analyses were carried out with a classical external calibration approach from 0.05 to 500 ng/ mL for each investigated element using 89Y (50 ng/ mL) as an internal standard to compensate for any signal instability, all data in cps were normalised to the internal standard. The operating conditions are shown in Table \u003cspan class=\"InternalRef\"\u003e2\u003c/span\u003e.\u003c/p\u003e\n\u003cdiv class=\"gridtable\"\u003e\n \u003ctable id=\"Tab2\" border=\"1\"\u003e\u003c/table\u003e\n\u003c/div\u003e\n\u003cp\u003e\u003cem\u003eTable 2 Parameters and operating conditions for the ICP-MS instrument\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cimg src=\"data:image/png;base64,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\"\u003e\u003c/em\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp\u003eDescriptive statistics were generated. Data were expressed as mean and standard deviation, as median and range for continuous variables and as absolute or relative frequencies for categorical variables. Data distribution was analysed using the Kolmogorov-Smirnov test and non-parametric statistics were considered.\u003c/p\u003e\n\u003cp\u003eThe paired Wilcoxon test was used to compare the trace metals levels present before inserting the bars and when removing the bars. Differences between groups were evaluated using the Mann-Whitney test for continuous variables and \u0026chi;2 or Fisher\u0026apos;s exact test for categorical variables. The Spearman correlation analysis was used to observe the correlations between interval time from bar placement to removal and increase of the trace metals levels\u003c/p\u003e\n\u003cp\u003eA P-value\u0026thinsp;\u0026lt;\u0026thinsp;0.05 was considered as statistically significant, all P values were based on two-tailed tests. Statistical analyses were performed using SPSSS for Windows version 20 (SPSS Inc, Chicago, Il, USA).\u003c/p\u003e\n\u003cp\u003eThe reference values for blood metal thresholds provided by the Italian National Institute of Health (Istituto Superiore di Sanit\u0026agrave;) were applied [\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e].\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eFifty-four patients were enrolled: 46 boys (85.2%) and 8 girls (14.8%). Mean age was 14.9 years (SD\u0026thinsp;\u0026plusmn;\u0026thinsp;3.82) at first procedure and 18.3 years (SD\u0026thinsp;\u0026plusmn;\u0026thinsp;3.27) at bar removal. The median time elapsed from bar placement to removal was 3.16 years, (range 2.15\u0026ndash;3.81 years). One patient was excluded from the analysis because of a very high Nickel value (\u0026gt;\u0026thinsp;10000 \u0026micro;g/l) recorded at the time of bar placement. The same patient had values slightly above the limit of normal at bar removal, so it was decided to consider the first sample as contaminated and to exclude the patient.\u003c/p\u003e\u003cp\u003eFor each metal of interest, differences between mean value of trace metal levels before MIRPE and at bar removal were calculated. Results are summarized in Table \u003cspan refid=\"Tab3\" class=\"InternalRef\"\u003e3\u003c/span\u003e. Chromium and molybdenum mean values were significantly increased (from 0,52\u0026thinsp;\u0026plusmn;\u0026thinsp;0,43 to 2,43\u0026thinsp;\u0026plusmn;\u0026thinsp;9,57 \u0026micro;g/l; p\u0026thinsp;\u0026lt;\u0026thinsp;0.001 and from 0,35\u0026thinsp;\u0026plusmn;\u0026thinsp;0,39 to 1,87\u0026thinsp;\u0026plusmn;\u0026thinsp;1,29 \u0026micro;g/l; p\u0026thinsp;\u0026lt;\u0026thinsp;0.001 respectively), without any correlation with interval time from placement to removal. Nickel and manganese mean values were also increased, but the differences were not statistically significant. For each metal of interest, the number of patients with value above the reference threshold before and after metal devices placement were compared. As regards chromium, the patients with value above the limits pre MIRPE were 47.2% while post MIRPE 62.3%, with no significant increase (p\u0026thinsp;\u0026gt;\u0026thinsp;0.05). No significant differences were observed also for manganese, molybdenum and nickel.\u003c/p\u003e\u003cp\u003e\u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab3\" border=\"1\"\u003e\u003ccaption language=\"En\"\u003e\u003cdiv class=\"CaptionNumber\"\u003eTable 3\u003c/div\u003e\u003cdiv class=\"CaptionContent\"\u003e\u003cp\u003eMean metal values pre and post MIRPE devices\u003c/p\u003e\u003c/div\u003e\u003c/caption\u003e\u003ccolgroup cols=\"5\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\"\u0026plusmn;\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\"\u0026plusmn;\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/th\u003e\u003cth align=\"left\" colname=\"c2\"\u003e\u003cp\u003ePatients\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c3\"\u003e\u003cp\u003ePre MIRPE\u003c/p\u003e\u003cp\u003emean\u0026thinsp;\u0026plusmn;\u0026thinsp;sd\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c4\"\u003e\u003cp\u003ePost MIRPE\u003c/p\u003e\u003cp\u003emean\u0026thinsp;\u0026plusmn;\u0026thinsp;sd\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c5\"\u003e\u003cp\u003ep value\u003c/p\u003e\u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eChromium\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e53\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e\u003cp\u003e0,52\u0026thinsp;\u0026plusmn;\u0026thinsp;0,43\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e\u003cp\u003e2,43\u0026thinsp;\u0026plusmn;\u0026thinsp;9,57\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e\u003cp\u003e\u003cb\u003e\u0026lt;\u0026thinsp;0.001\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eManganese\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e53\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e\u003cp\u003e12,69\u0026thinsp;\u0026plusmn;\u0026thinsp;7,84\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e\u003cp\u003e19,81\u0026thinsp;\u0026plusmn;\u0026thinsp;45,97\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e\u003cp\u003e0.26\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eMolybdenum\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e53\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e\u003cp\u003e0,35\u0026thinsp;\u0026plusmn;\u0026thinsp;0,39\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e\u003cp\u003e1,87\u0026thinsp;\u0026plusmn;\u0026thinsp;1,29\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e\u003cp\u003e\u003cb\u003e\u0026lt;\u0026thinsp;0.001\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eNickel\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e53\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e\u003cp\u003e4,24\u0026thinsp;\u0026plusmn;\u0026thinsp;12,50\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e\u003cp\u003e80,80\u0026thinsp;\u0026plusmn;\u0026thinsp;305,28\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e\u003cp\u003e0.31\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/colgroup\u003e\u003ctfoot\u003e\u003ctr\u003e\u003ctd colspan=\"5\"\u003e\u003cem\u003eMIRPE Minimally Invasive Repair of Pectus Excavatum\u003c/em\u003e\u003c/td\u003e\u003c/tr\u003e\u003c/tfoot\u003e\u003c/table\u003e\u003c/div\u003e\u003c/p\u003e\u003cp\u003ePatients with more than one bar did not display higher level of metals after MIRPE compared to those with one bar only (Table \u003cspan refid=\"Tab4\" class=\"InternalRef\"\u003e4\u003c/span\u003e).\u003c/p\u003e\u003cp\u003e\u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab4\" border=\"1\"\u003e\u003ccaption language=\"En\"\u003e\u003cdiv class=\"CaptionNumber\"\u003eTable 4\u003c/div\u003e\u003cdiv class=\"CaptionContent\"\u003e\u003cp\u003eMetals values according to number of bars\u003c/p\u003e\u003c/div\u003e\u003c/caption\u003e\u003ccolgroup cols=\"4\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/th\u003e\u003cth align=\"left\" colname=\"c2\"\u003e\u003cp\u003eN\u0026deg; bars\u0026thinsp;=\u0026thinsp;1\u003c/p\u003e\u003cp\u003eN\u0026thinsp;=\u0026thinsp;33\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c3\"\u003e\u003cp\u003eN\u0026deg; bars\u0026thinsp;\u0026gt;\u0026thinsp;1\u003c/p\u003e\u003cp\u003eN\u0026thinsp;=\u0026thinsp;20\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c4\"\u003e\u003cp\u003ep value\u003c/p\u003e\u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003emean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003emean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eChromium PRE\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e0.56\u0026thinsp;\u0026plusmn;\u0026thinsp;0.44\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003e0.44\u0026thinsp;\u0026plusmn;\u0026thinsp;0. 39\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e0.32\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eChromium POST\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e3.33\u0026thinsp;\u0026plusmn;\u0026thinsp;12.07\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003e0.93\u0026thinsp;\u0026plusmn;\u0026thinsp;1.09\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e0.38\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eManganese PRE\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e12.05\u0026thinsp;\u0026plusmn;\u0026thinsp;8\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003e13.76\u0026thinsp;\u0026plusmn;\u0026thinsp;7.64\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e0.44\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eManganese POST\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e24.15\u0026thinsp;\u0026plusmn;\u0026thinsp;58.09\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003e12.65\u0026thinsp;\u0026plusmn;\u0026thinsp;3.72\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e0.38\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eMolybdenum PRE\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e0.23\u0026thinsp;\u0026plusmn;\u0026thinsp;0.35\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003e0.54\u0026thinsp;\u0026plusmn;\u0026thinsp;0.39\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e\u003cb\u003e0.001\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eMolybdenum POST\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e1.92\u0026thinsp;\u0026plusmn;\u0026thinsp;1.46\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003e1.81\u0026thinsp;\u0026plusmn;\u0026thinsp;1\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e0.77\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eNickel PRE\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e3.06\u0026thinsp;\u0026plusmn;\u0026thinsp;5.65\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003e6.18\u0026thinsp;\u0026plusmn;\u0026thinsp;19.17\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e0.38\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eNickel POST\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e72.62\u0026thinsp;\u0026plusmn;\u0026thinsp;231.24\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003e94.30\u0026thinsp;\u0026plusmn;\u0026thinsp;405.83\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e0.81\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/colgroup\u003e\u003c/table\u003e\u003c/div\u003e\u003c/p\u003e\u003cp\u003eConsidering the number of stabilizers, no significant differences were found between the number of stabilizers and differences between blood levels.\u003c/p\u003e\u003cp\u003eNo significant difference based on age at first procedure or time before the second procedure could be found.\u003c/p\u003e\u003cp\u003eA higher mean value of nickel among female patients could be observed although the analysis of differences between male and female subjects didn`t reveal any significative statistical difference.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eIn recent years, interest in studying the correlation between metal surgical implants and metal levels in biological tissues has significantly grown.\u003c/p\u003e\u003cp\u003eIn particular, in orthopaedics, this issue has been widely discussed and studied for many years. Consumption and corrosion of prostheses metal components con result in tissue release of ions, particularly chromium and cobalt. Other materials such as titanium can also be released from such devices [\u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e] [\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e].\u003c/p\u003e\u003cp\u003eThis phenomenon can lead to severe local tissue reactions up to necrosis and potential systemic adverse effects due to dispersion into the bloodstream of ions. Peri-implant biological analyses can detect the presence of metals compatible with device composition and trace metals can also be found in tissues and organs far from the primary site [\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e] [\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e].\u003c/p\u003e\u003cp\u003eMIRPE technique was initially described by Nuss [\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e] and is nowadays considered as the gold standard for pectus excavatum repair and its popularity is increasing. Treated patients are in most cases young, which enhances the need in determining possible local and systemic impact of implanted metallic devices in a short and long term.\u003c/p\u003e\u003cp\u003eCundy and Kirby were the first to raise the attention to trace metal levels in the blood of patients undergoing MIRPE in 2012 [\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e] and described an increased serum chromium.\u003c/p\u003e\u003cp\u003eFortmann et al [\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e] found elevated metal values in various biological tissues, including plasma, urine, and peri-prosthetic tissue.\u003c/p\u003e\u003cp\u003eIn 2021 [\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e] we analysed blood metal levels in two groups of patients pre and post maintenance of bars and stabilizers and we found a significant increase in blood chromium values and a general upward trend in the metals studied. At the same time, stabilizers seemed to correlate to higher levels of blood of the metals, suggesting a release caused mainly by friction between the metal components.\u003c/p\u003e\u003cp\u003eIn the present paper, we performed a longitudinal evaluation in the same patient before and after bar and stabilizer maintenance, thus reducing one of the major biases of most previous studies, namely individual variability.\u003c/p\u003e\u003cp\u003eWe confirm that chromium concentrations increase in patients after MIRPE, both considering the percentage of patients above the threshold and considering the mean value pre- and post-surgical correction. Interestingly, differently from our previous findings, in this work we were not able to find any significant difference correlated to the number of stabilizers used. At least one stabilizer was always used in this population so it was not possible to perform analyses on patients without stabilizers to possibly confirm previous evidence.\u003c/p\u003e\u003cp\u003eThe clinical impact of metal release in patients after MIRPE has not been yet established. Systemic toxicity effects by metal release were never reported in PE population, to our knowledge. However, we cannot exclude potential general toxicity consequences in patients with such increased blood metal levels. Evaluating the potential risk of metal toxicity in patients operated for MIRPE, we have to consider that abnormal metal levels can be found in different biological tissues and for long time after MIRPE according to the studies of Fortmann. Also according to Seyrek and Akkus [\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e] the values of metals such as nickel have found to be increased even after devices removal, as demonstrated by studying hair samples. In our opinion, the results of our study enhance once more the need of further investigating the role of metal release in PE population. This is paramount, considering that pectus excavatum population is mainly composed by young and healthy patients, who are exposed to un unknown risk for a prolonged period.\u003c/p\u003e\u003cp\u003eMoreover, it has been hypothesized that local irritative symptoms, such as local swelling, seroma, wound healing disorders, or pleural effusion, can be associated with metal release after MIRPE. These signs must be differentiated from metal allergy which seems to appear in 0.5\u0026ndash;6.4% of MIRPE patients [\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e]. Interestingly, pre operative metal allergy testing doesn\u0026rsquo;t seem to be associated with a reduction in bar allergy symptoms [\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e].\u003c/p\u003e\u003cp\u003eFortmann et al found an increased risk of irritative symptoms of the soft tissue and pleural effusion in patients with abnormal tissue metal levels. In contrast, none of the patients described in our study presented similar symptoms.\u003c/p\u003e\u003cp\u003eSolutions to lowering the risk of metal release such as, for example, a titanium nitride coating apparently do not display any protective effect if compared with uncoated device placement [\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e]. The use of titanium bar instead of steel bars could be another attempt of reducing toxicity by metal release, however we do not have any data to support this at the present time.\u003c/p\u003e\u003cp\u003eDifferently from our previous study, in which different cohorts of patients were compared, in the present study we have analysed metal levels in the same cohort pre and post MIRPE, which represents the main point of strength. The number of patients, although higher than in other studies, remains the main limitation of this study as it cannot be excluded that results could be subjected to wider variations when considering a larger sample size. Another critical issue that should not be underestimated is the possible interference of external variables in the concentration of trace metals (e.g., diet, geographical area). Another limitation of this study is the use of reference values for the adult population.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003ePatients undergoing MIRPE displayed increased blood levels of chromium and molybdenum. At present, there was no correlation between blood levels and symptoms correlated with these findings in the short- and medium-term follow-up. However, a pathological role of these results cannot be ruled out with certainty. Although generally considered safe from the point of view of biocompatibility, future developments of MIRPE also depend on the evolution of materials.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eMIRPE, PE, ICP-MS.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003ch2\u003eConflict of interest:\u003c/h2\u003e\u003cp\u003enone declared.\u003c/p\u003e\u003c/p\u003e\u003ch2\u003eAuthor Contribution\u003c/h2\u003e\u003cp\u003eMichele Torre: Conceptualization; Writing\u0026mdash;original draft; Supervision; Project Luca Genova Gaia: Conceptualization; Data curation; Writing\u0026mdash;original draft. Federica Lena: Writing - original draft. Maria Grazia Calevo: Formal analysis; Methodology; Supervision; Writing\u0026mdash;review \u0026amp; editing. Maria Raso: Formal analysis. Sebastiano Barco: Data curation. Francesca Di Gaudio: Formal analysis; Methodology; Supervision; Writing\u0026mdash;review \u0026amp; editing. Giuliana Cangemi: Conceptualization; Methodology; Supervision; Writing\u0026mdash;review \u0026amp; editingFrancesca Di Gaudio and Giuliana Cangemi contributed equally to this manuscript.\u003c/p\u003e\u003ch2\u003eData Availability\u003c/h2\u003e\u003cp\u003eThe data underlying this article will be shared on reasonable request to the corresponding author.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e\u003cspan\u003eJaroszewski DE, Ewais MAM, Chao CJ, Gotway MB, Lackey JJ, Myers KM et al (2016) Success of Minimally Invasive Pectus Excavatum Procedures (Modified Nuss) in Adult Patients (\u0026ge;\u0026thinsp;30 Years). Ann Thorac Surg. ;102(3):993\u0026ndash;1003.Available from: \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttp://dx.doi.org/10.1016/j.athoracsur.2016.03.105\u003c/span\u003e\u003cspan address=\"10.1016/j.athoracsur.2016.03.105\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eNuss D, Kelly RE (2008) Minimally Invasive Surgical Correction of Chest Wall Deformities in Children (Nuss Procedure). Adv Pediatr 55(1):395\u0026ndash;410\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eTorre M, Genova Gaia L, Calevo MG, Wong M, Raso M, Barco S et al (2021) Blood metal levels after minimally invasive repair of pectus excavatum. Interact Cardiovasc Thorac Surg 33(1):76\u0026ndash;81\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eFortmann C, G\u0026ouml;en T, Kr\u0026uuml;ger M, Ure BM, Petersen C, K\u0026uuml;bler JF (2017) Trace metal release after minimally-invasive repair of pectus excavatum. PLoS ONE 12(10):1\u0026ndash;11\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eFortmann C, Goeen T, Zinne N, Wiesner S, Ure BM, Petersen C et al (2022) Nickel contamination after minimally-invasive repair of pectus excavatum persists after bar removal. PLoS One. ;17(10 October):1\u0026ndash;13. Available from: \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttp://dx.doi.org/10.1371/journal.pone.0275567\u003c/span\u003e\u003cspan address=\"10.1371/journal.pone.0275567\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eDas KK, Reddy RC, Bagoji IB, Das S, Bagali S, Mullur L et al (2019) Primary concept of nickel toxicity - An overview. J Basic Clin Physiol Pharmacol 30(2):141\u0026ndash;152\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eMurthy MK, Khandayataray P, Padhiary S, Samal D (2023) A review on chromium health hazards and molecular mechanism of chromium bioremediation. Rev Environ Health. ;38(3):461\u0026ndash;78. Available from: \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://doi.org/10.1515/reveh-2021-0139\u003c/span\u003e\u003cspan address=\"10.1515/reveh-2021-0139\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eObermeyer RJ, Goretsky MJ (2012) Chest Wall Deformities in Pediatric Surgery. Surg Clin North Am. ;92(3):669\u0026ndash;84. Available from: \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttp://dx.doi.org/10.1016/j.suc.2012.03.001\u003c/span\u003e\u003cspan address=\"10.1016/j.suc.2012.03.001\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eAlimonti A, Bocca B, Mattei D, Pino A (2010) Biomonitoraggio della popolazione italiana per l\u0026rsquo;esposizione ai metalli: valori di riferimento 1990\u0026ndash;2009. Rapp ISTISAN. ;8\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eWitzleb WC, Ziegler J, Krummenauer F, Neumeister V, Guenther KP (2006) Exposure to chromium, cobalt and molybdenum from metal-on-metal total hip replacement and hip resurfacing arthroplasty. Acta Orthop 77(5):697\u0026ndash;705\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eSunderman FW, Hopfer SM, Swift T, Rezuke WN, Ziebka L, Highman P et al (1989) Cobalt, chromium, and nickel concentrations in body fluids of patients with porous-coated knee or hip prostheses. J Orthop Res 7(3):307\u0026ndash;315\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eHo JH, Leikin JB, Dargan PI, Archer JRH, Wood DM, Brent J (2017) Metal-on-Metal Hip Joint Prostheses: a Retrospective Case Series Investigating the Association of Systemic Toxicity with Serum Cobalt and Chromium Concentrations. J Med Toxicol 13(4):321\u0026ndash;328\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eMatusiewicz H (2014) Potential release of in vivo trace metals from metallic medical implants in the human body: From ions to nanoparticles - A systematic analytical review. Acta Biomater. ;10(6):2379\u0026ndash;403. Available from: \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttp://dx.doi.org/10.1016/j.actbio.2014.02.027\u003c/span\u003e\u003cspan address=\"10.1016/j.actbio.2014.02.027\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eNuss D, Kelly RE, Croitoru DP, Katz ME (1998) A 10-year review of a minimally invasive technique for the correction of pectus excavatum. J Pediatr Surg 33(4):545\u0026ndash;552\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eCundy TP, Kirby CP (2012) Serum metal levels after minimally invasive repair of pectus excavatum. J Pediatr Surg. ;47(8):1506\u0026ndash;11. Available from: \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttp://dx.doi.org/10.1016/j.jpedsurg.2012.02.005\u003c/span\u003e\u003cspan address=\"10.1016/j.jpedsurg.2012.02.005\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eSeyrek Y, Akkuş M (2021) A prospective study on long-term trace metal accumulation in hair: Is there any difference between minimally invasive repair of pectus excavatum and carinatum? J Pediatr Surg 56(12):2253\u0026ndash;2257\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eGałązka P, Leis K, Kroczek K, Baska A, Kazik J, Czajkowski R (2021) Metal allergy after the Nuss procedure for pectus excavatum: a review. Postep Dermatologii i Alergol 37(6):848\u0026ndash;852\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eOchoa B, Lai K, Eldredge RS, Viswanath V, Bae JO, Lee J, McMahon LE, Notrica DMPB (2024) Preoperative Metal Allergy Testing for Pectus Excavatum Repair Does Not Effectively Identify Patients Who Develop Metal bar Allergy. J Pediatr Surg May; 59(5):956\u0026ndash;961\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eFortmann C, Goen T, Wiesner S, Hegermann J, Kiblawi R, Dohna M et al (2023) Titanium nitride coating of pectus bar increases metal contamination after minimally-invasive repair of pectus excavatum. PLoS ONE 18(10 October):1\u0026ndash;14\u003c/span\u003e\u003c/li\u003e\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"pediatric-surgery-international","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"pesi","sideBox":"Learn more about [Pediatric Surgery International](http://link.springer.com/journal/383)","snPcode":"383","submissionUrl":"https://submission.nature.com/new-submission/383/3","title":"Pediatric Surgery International","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"thoracic surgery, pediatric surgery, pectus excavatum, minimally invasive surgery, blood metal levels","lastPublishedDoi":"10.21203/rs.3.rs-7918550/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7918550/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cb\u003eObjectives\u003c/b\u003e\u003c/p\u003e\u003cp\u003eMinimally Invasive Repair of Pectus Excavatum (MIRPE) is the most popular technique to repair pectus excavatum in young patients. One or more metallic bars are inserted and maintained for at least 2\u0026ndash;3 years. Few reports about possible metal release in these patients were published recently. The study aimed to search for an increase in blood metal levels in patients after MIRPE and to investigate if surgical details (number of bars and stabilizers) were correlated with metal release.\u003c/p\u003e\u003cp\u003e\u003cb\u003eMethods\u003c/b\u003e\u003c/p\u003e\u003cp\u003eWe have prospectively studied blood levels of chromium, nickel, molybdenum and manganese before bar implant in a group of patients undergoing MIRPE between 2017 and 2019 and, in the same patients, at the moment of bar removals between 2020 and 2022. All our patients had the same stainless-steel bar. Blood samples were analysed using inductively coupled plasma mass spectrometry.\u003c/p\u003e\u003cp\u003e\u003cb\u003eMain results\u003c/b\u003e\u003c/p\u003e\u003cp\u003eWe enrolled a total of 53 (10 females) patients. Median age at MIRPE was 15.4 years. After a bar maintenance median time of 3.1 years, we found significantly (p\u0026thinsp;\u0026lt;\u0026thinsp;.05) higher mean levels of chromium (2.43 versus 0.52 \u0026micro;g/l) and molybdenum (1.87 versus 0.35 \u0026micro;g/l), and higher mean levels of nickel (4.24 versus 80.80 \u0026micro;g/l) and manganese (12.69 versus 19.81 \u0026micro;g/l) without statistical significance. No differences were found regarding the number of bars, stabilizers implanted or gender. No patients had clinical symptoms of metallosis.\u003c/p\u003e\u003cp\u003e\u003cb\u003eConclusions\u003c/b\u003e\u003c/p\u003e\u003cp\u003eWe demonstrated that metal blood levels increase in patients with retrosternal bars after MIRPE. Clinical implications of our finding are still unknown.\u003c/p\u003e","manuscriptTitle":"Increased chromium and molybdenum blood levels after minimally-invasive repair of pectus excavatum","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-11-06 13:52:51","doi":"10.21203/rs.3.rs-7918550/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2025-12-29T16:23:53+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-12-29T09:36:27+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-12-19T10:00:45+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"195128719411106571758174474277398743275","date":"2025-12-19T08:56:56+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"105808620256456269971015078626995298353","date":"2025-12-09T09:26:43+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2025-10-27T18:07:49+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-10-25T11:25:45+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2025-10-24T02:31:31+00:00","index":"","fulltext":""},{"type":"submitted","content":"Pediatric Surgery International","date":"2025-10-21T21:42:12+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"pediatric-surgery-international","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"pesi","sideBox":"Learn more about [Pediatric Surgery International](http://link.springer.com/journal/383)","snPcode":"383","submissionUrl":"https://submission.nature.com/new-submission/383/3","title":"Pediatric Surgery International","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false}}],"origin":"","ownerIdentity":"b63ec471-dca1-4d37-87ff-4080cfad0bd2","owner":[],"postedDate":"November 6th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[],"tags":[],"updatedAt":"2026-02-16T16:05:15+00:00","versionOfRecord":{"articleIdentity":"rs-7918550","link":"https://doi.org/10.1007/s00383-026-06303-y","journal":{"identity":"pediatric-surgery-international","isVorOnly":false,"title":"Pediatric Surgery International"},"publishedOn":"2026-02-09 15:59:24","publishedOnDateReadable":"February 9th, 2026"},"versionCreatedAt":"2025-11-06 13:52:51","video":"","vorDoi":"10.1007/s00383-026-06303-y","vorDoiUrl":"https://doi.org/10.1007/s00383-026-06303-y","workflowStages":[]},"version":"v1","identity":"rs-7918550","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7918550","identity":"rs-7918550","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}