A Performance Comparison of Heterostructure Surface Plasmon Resonance Biosensor for the Diagnosis of Novel Coronavirus SARS-CoV-2

This paper presents a performance comparison of heterostructure surface plasmon resonance (SPR) biosensors for the application of Novel Coronavirus SARS-CoV-2 diagnosis. The comparison is performed and compared with the existing literature based on the performance parameters in terms of several prisms such as BaF 2 , BK 7 , CaF 2 , CsF, SF 6 , and SiO 2 , several adhesion layers such as TiO 2 , Chromium, plasmonic metals such as Ag, Au, and two-dimensional (2D) transition metal dichalcogenides (TMDs) materials such as BP, Graphene, PtSe 2 MoS 2 , MoSe 2 , WS 2 , WSe 2 . To study the performance of the heterostructure SPR sensor, the transfer matrix method (TMM) is applied, and to analyses, the electric field intensity (EFI) near the graphene-sensing layer contact, the finite-difference time-domain (FDTD) approach is utilized. Numerical results show that the heterostructure comprised of CaF 2 /TiO 2 /Ag/BP/Graphene/Sensing-layer has the best sensitivity and detection accuracy. The proposed sensor has an angle shift sensitivity of 390°/refractive index unit (RIU). Furthermore, the sensor achieved a detection accuracy (DA) of 0.464, a quality factor (QF) of 92.86/RIU, a figure of merit (FOM) of 87.95, and a combined sensitive factor (CSF) of 85.28. Furthermore, varied concentrations (0nM to 1000nM) of biomolecule binding interactions between ligands and analytes have been observed for the prospects of diagnosis of the SARS-CoV-2 virus. Results demonstrate that the proposed sensor is well suited for real-time and label-free detection particularly SARS-CoV-2 virus detection.