Clinical Values and Functional Analysis Of KMT2A/B/C/D/E/F in Gastric Cancer by Integrated Bioinformatics Analysis

KMT2A/B/C/D/E/F have been identified be involved in the tumor progression of gastric cancer (GC). However, the clinical significance and function of the 6 KMT2s have not yet been analyzed. Here, we investigated the transcriptional and survival data of KMT2s family genes in GC based on integrated bioinformatics analysis. cBioPortal was used to analyze the alteration frequency and functional networks of KMT2s in GC. And GO and KEGG pathways were also identified. Gene enrichment analysis was performed to investigate the networks of kinase, miRNAs and transcription factor target. We found that KMT2s were highly expressed in GC, and associated with tumor stages and grades. Besides, higher KMT2s expression were significantly associated with shorter overall survival (OS), progression-free survival (FP) and post-progression survival (PPS). Also, promoter methylation levels of KMT2s were positively associated with KMT2s expression and clinical data. Moreover, high mutation rate of KMT2s (40%) was also observed in GC patients. Functional networks analysis suggested that KMT2s might regulate histone lysine methylation and chromatin organization via PI3K/AKT and MAPK signaling pathways involving in some kinase, miRNA and transcription factor. Taken together, these findings suggested that KMT2A/B/C/D/E/F may be prognostic and therapeutic biomarkers of patients with GC.