Effects of prostaglandin E2 and vascular endothelial growth factor on sperm might lead to endometriosis-associated infertility

Lee TC, Te-Ching Lee, Han-Chen Ho, Ho HC
Fertility and sterility · 2011 · doi:10.1016/j.fertnstert.2010.08.040 · PMID:20864099
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Abstract

Significantly higher levels of prostaglandin E2 and vascular endothelial growth factor were associated with the severity of endometriosis. In this study, pathologic concentrations of prostaglandin E2 and vascular endothelial growth factor found in endometriotic women significantly inhibited sperm motility, acrosome reaction, and sperm-oocyte interaction, which might result in endometriosis-associated subfertility/infertility.

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Condition tags

endometriosisinfertility

MeSH descriptors

Dinoprostone Endometriosis Infertility, Female Sperm Motility Vascular Endothelial Growth Factor A Acrosome Reaction Acrosome Reaction Acrosome Reaction Animals Cricetinae Dinoprostone Dinoprostone Endometriosis Female Humans Infertility, Female In Vitro Techniques Male Neovascularization, Physiologic Neovascularization, Physiologic

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