Review and screening of key genes in esophageal squamous cell carcinoma

Review and screening of key genes in esophageal squamous cell carcinoma | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Review and screening of key genes in esophageal squamous cell carcinoma Xizi Sun This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-498257/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Esophageal squamous cell carcinoma (ESCC) is the most common type of human esophageal cancer with high mortality due to late stage diagnosis. Efforts have been made to figure out the genetic events underlying its carcinogenesis and progression, but the molecular mechanisms of these processes remain elusive. To identify the candidate genes involved in ESCC, literature about significantly mutated genes (SMGs) was extensively reviewed and gene expression profiles of GSE161533, GSE20347 and GSE77861 were downloaded from the Gene Expression Omnibus (GEO) database. Following the identification of 230 differentially expressed genes (DEGs), hub gene identification was performed by the plug-in MCODE in Cytoscape software. 14 hub genes were identified which were enriched in cell cycle, DNA replication and p53 signaling pathway. In summary, genes mentioned in this study may provide potential targets for treatment and diagnosis of ESCC and help us better understand the pathogenesis and progression of ESCC from genetic perspective. Cancer Biology Oncology Bioinformatics Computational Biology esophageal squamous cell carcinoma (ESCC) cancer genetics mutated genes Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Introduction Esophageal cancer is the eighth most common cancer and the sixth leading cause of cancer-related mortality in the world 1,2 . ESCC is the major histological type accounting for about 90% of the 456,000 incident esophageal cancers each year 3 . The 5-year survival rate for ESCC is about 18%, a number that reflects limited approaches of early diagnosis and treatment of ESCC 4 . Thus, there is a great need to further figure out the molecular mechanisms and to develop better diagnostic and therapeutic methods for ESCC. The pathogenesis of ESCC is believed to be a multi-step process and the genetic determinants remain elusive. Increasing evidence shows that gene mutation plays a key role in ESCC tumorigenesis and tumor progression. These genes include upregulated genes ADAM29 , AJUBA , CBX4/8, CCND1(BCL1/PRAD1), EGFR(ERBB1), ERBB2(HER-2), FAM135B, FGFR1, KMT2D(MLL2/MLL4/ALR), MMP14, MYC, NOTCH, NRF2(NFE2L2), PIK3CA, RB1, SOX2, TP53, XPO1, YAP1 and downregulated genes CDKN2A, CREBBP/EP300, CUL3, FAT1, FBXW7, KMT2C(MLL3), PTEN, TET2, TGFBR2, ZFP36L2, ZNF750 5-11 (Table 1). Genes involved in cell cycle, the Notch signaling pathway, epigenetic processes and RTK/PI3K/AKT circuit are frequently altered 12 . Cell cycle progression is changed mostly by TP53 mutation, CDKN2A deletion/mutation and CCND1 amplification 5 . TP53 is the most significantly mutated genes (SMGs) in ESCC with mutation frequency reaching 93% 12 . NOTCH plays a dual role as both a tumor suppressor pathway and an oncogenic pathway, for which further studies are warranted 13 . Abudureheman et al. have shown that overexpression of KMT2D facilitates ESCC tumor progression, and that it may exert oncogenic role via activation of epithelial-to-mesenchymal transition (EMT) 14 . In a large-sample study with ESCC in China 15 , PIK3CA was significantly overexpressed in cancer tissue and its overexpression was independently associated with higher risk of local recurrence 15 . EGFR and FGFR1 were the most often amplified RTK/RAS-related genes in ESCC 9 , of which the inhibitors have been under therapeutic evaluation 16,17 . It’s worth noting that conflicting results were found in studies about prognostic value of TP53 overexpression in ESCC 18-21 , of which the biological functions were undoubted. In general, there are still significant gaps to fill to figure out the exact mechanism of carcinogenesis and to develop precision treatment means of ESCC. Gene chip or gene profile is an advanced gene detection technique that can quickly detect all the genes within the same sample at one time 22 . Last two decades have seen more and more studies of genetic alterations in cancers via microarray technology and bioinformatics analysis, which have helped us identify the differentially expressed genes (DEGs) and related pathways in ESCC. However, the results were always limited or inconsistent because of tissue or sample heterogeneity in independent studies, or the results were produced from a single cohort study. Thus, integrated bioinformatics analysis combined with gene profiling technique might be innovative and solve this disadvantage. In this work, we downloaded three microarray datasets GSE161533, GSE20347, GSE77861 from NCBI-Gene Expression Omnibus database (NCBI-GEO) (Available online: https://www.ncbi.nlm.nih.gov/geo ) followed by DEGs identification via GEO2R analysis. Subsequently, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and protein-protein interaction (PPI) network analysis were conducted to help us understand the molecular mechanisms of carcinogenesis and progression of ESCC. In summary, 230 DEGs and 14 hub genes were found in this study, which may serve as potential biomarkers for individualized prevention, early diagnosis and precise treatment. Table1. Expression of significantly mutated genes (SMGs) and their functions in ESCC Gene Symbol Expression in ESCC Function of the Product Reference ADAM29 upregulated a member of ADAM family which plays an important role in regulating cell-to-cell or cell-matrix interactions 6,23 AJUBA upregulated functions as a regulator of the Hippo pathway 7,24 BAP1 lack study a deubiquitinating enzyme involved in the regulation of cell growth 25 CBX4/8 upregulated promotes cell proliferation, colony formation,and cell invasion 8 CCND1 (BCL1/PRAD1) upregulated regulation of cell cycle 7,26 CDKN2A downregulated regulation of cell cycle 9 CREBBP lack study Serves as global transcriptional coactivators and integrators of numerous signaling pathways 7 CUL3 downregulated core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes 10,11 DCDC1 lack study microtubule-binding protein which plays an important role in mediating dynein-dependent transport 11 EGFR(ERBB1) upregulated stimulates proliferation of different cell types 27,28 EP300 upregulated functions as histone acetyltransferase and regulates transcription via chromatin remodeling 29 ERBB2 (HER-2/NEU/NGL/MLN19) upregulated regulates cell growth and differentiation 30 FAM135B upregulated promotes cell proliferation likely through its direct interaction with growth factor GRN 6,23,31 FAT1 downregulated inhibits cell proliferation and migration 32 FBXW7 downregulated one of the F-box proteins inducing the degradation of positive cell-cycle regulators 33-35 FGFR1 upregulated regulation of cell proliferation, differentiation, migration, and angiogenesis 5,36 KDM6A(UTX) lack study a histone demethylase essential for cellular reprogramming 37 KMT2C(MLL3) downregulated regulation of expression of genes involved in cell growth and migration 38 KMT2D (MLL2/MLL4/ALR) upregulated histone methyltransferase 7,14 MMP14 upregulated endopeptidase that degrades various components of the extracellular matrix 24 MYC upregulated transcription factor that binds DNA in a non-specific manner 39 NOTCH upregulated regulation of squamous differentiation 13 NRF2(NFE2L2) upregulated transcription factor that plays a key role in the response to oxidative stress 40,41 PIK3CA upregulated the p110α catalytic subunit of PI3K 15,42,43 PTCH lack study a key modulator of signaling in the Hh pathway 44 PTEN downregulated a phosphatase which inhibits cell migration, spreading and focal adhesions 45 RB1 upregulated inhibits cell migration and invasion 46 SOX2 upregulated transcriptional regulator having crucial roles in maintenance of progenitor and neural stem cells and neuroendocrine differentiation 8,47 TET2 downregulated dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) 48,49 TGFBR2 downregulated a key mediator of TGF-β signaling 50,51 TP53 upregulated regulation of cell cycle, apoptosis and DNA damage repairing 18-21 XPO1 upregulated mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs 5 YAP1 upregulated the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression 24,52 ZFP36L2 downregulated zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts 10 ZNF750 downregulated transcription factor involved in epidermis differentiation 53 Results Identification of DEGs in ESCC After analyzing with GEO2R with adj. P value 1, DEGs (1504 in GSE161533 , 1680 in GSE20347 and 972 in GSE77861 ) were identified. The intersection of three gene sets of DEGs contains 230 genes as shown in venn diagram (Fig.1), which consists of 144 upregulated genes and 86 downregulated genes between normal and ESCC tissues. GO and KEGG enrichment analysis of DEGs To annotate the DEGs, GO and KEGG enrichment analysis were performed using DAVID, with P value<0.05 considered significant. GO analysis results (Fig.2) showed that changes in biological processes (BP) were mainly enriched in oxidation-reduction process, positive regulation of cell proliferation, cell-cell adhesion and inflammatory response. Changes in cellular components (CC) of DEGs were significantly enriched in cytoplasm, extracellular exosome, cytosol and extracellular space. Changes in molecular function (MF) of DEGs were enriched in calcium ion binding, protein homodimerization activity, cadherin binding involved in cell-cell adhesion and actin binding. And KEGG analysis showed that DEGs mainly enriched in transcriptional misregulation in cancer and p53 signaling pathway. PPI network construction and hub genes identification Prediction of the functional interaction was conducted by STRING online and the PPI network of DEGs was constructed by Cytoscape (Fig.3). Subsequently, 14 hub genes were identified with MCODE score > 10 (Fig.4). Hub gene analysis Among all hub genes, only ESPL1 is down-regulated. GO and KEGG analysis network of hub genes was performed using ClueGO (Fig.5). Result showed that hub genes were mainly enriched in positive regulation of mitotic cell cycle phase transition, regulation of cytokinesis and DNA replication origin binding. Subsequently, we conducted an extensive literature search on the hub genes. AURKA, which is significantly overexpressed in various cancers including ESCC 54 has been reported to contribute to the malignant development of ESCC 55 and Jin et al. have revealed part of the mechanism underlying this process 56 . Ke et al. showed that downregulated CDC6 functioned as downstream molecule of RYBP in the inhibition of cell proliferation in ESCC 57 . An association between overexpression of DTL and detrimental outcome in basal-like and luminal breast cancer and non-small cell lung adenocarcinomas but not esophagus-stomach cancer was found in another bioinformatic analysis 58 . The gene ECT2 encoding guanine nucleotide exchange factor (GEF) functions as an oncogene in a wide spectrum of cancers 59 . Sun et al. 60 showed that ECT2 promoted proliferation and metastasis of ESCC via the RhoA-ERK signaling pathway. And the overexpression of ECT2 often suggests a poor outcome in cancers, especially in breast cancer 61,62 , gastric cancer 63 , non-small-cell lung cancer 64,65 , and ESCC 65 . ESPL1 , the dysregulation of which plays an important role in the development of aneuploidy 66 , is a candidate oncogene in luminal B breast cancers 67 . Studies have revealed the significant association between high expression of FOXM1 and poor outcome of ESCC 68,69 . GTSE1 was found to promote malignant behavior in hepatocellular carcinoma (HCC) 70 , confer to cisplatin resistance in gastric cancer cells 71 and to be involved in breast cancer progression 72 . Overexpression of KIF14 in ESCC was validated in a study, in which KIF14 was a downstream gene regulated by the miR-375/MMP13 axis 73 . The overexpression of MCM10 in ESCC has been confirmed in an experiment using semiquantitative reverse transcription-PCR 74 . MCM2, of which the diagnostic value has been confirmed in different types of cancers 75-77 was found to be a more reliable and useful marker than Ki67 in assessing tumor growth and tumor aggressiveness in patients with ESCC 78 and in screening patients at high risk of ESCC in mass surveys 79 . RFC4 has been found to be overexpressed in several cancers 80 , while study about its role in ESCC remains blank. RRM1 has been found to be an oncogene in lung cancer 81 , the overexpression of which is involved in tumor progression 82 and is transforming to the therapeutic target 83,84 . A large-scale, long-term follow-up retrospective analysis 85 showed that TOP2A expression was not only associated with perineural invasion and poorer differentiation, but it could be also an independent prognostic factor. Additionally, as TOP2A is a specific marker for the use of chemotherapeutic drugs such as anthracycline, therapy targeting TOP2A protein may be an appropriate way of individualized treatment and improving the prognosis of ESCC patients. Studies 86,87 using immunohistochemical analysis confirmed that UBE2C protein expression was upregulated in all ESCC cases, but absent in the histologically normal tumor surrounding tissues, pointing out its role as a diagnostic biomarker for ESCC. Besides, high expression of UBE2C is a marker of poor prognosis in ESCC 87 . Table2. Fuction and clinical significance of 14 hub genes with MCODE score ≥10. “→” indicates “was significantly associated with” Additional Declarations No competing interests reported. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-498257","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":26344187,"identity":"e342e3ed-3416-49c1-89dc-5ad88bc3e80c","order_by":0,"name":"Xizi Sun","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA10lEQVRIiWNgGAWjYJCCAxDqYOODhAobYrUkgLU0Gzw4k0asPWAtDGySD9sOEVYsPyP94eHCHzZ58o6H2yoS2A4w8Ld3J+DVYnDmQMLhGQlpxYYHDrbdSOC5wyBx5uwG/FrYGw4c5kk4nLixAaRF4hmDgUQufi3yzYwNcC0FCQaHCWthON7MANYyn+FgG0NCAhFaDM4cA2pJS0vcAAxkiYQDaTwE/QIMscefeWxsEufPOP7w489/NnL87b0EHAa37sYBMM1DnHKwdf0NxCseBaNgFIyCkQUAg4FUNYYlEUwAAAAASUVORK5CYII=","orcid":"","institution":"Huazhong University of Science and Technology","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Xizi","middleName":"","lastName":"Sun","suffix":""}],"badges":[],"createdAt":"2021-05-06 05:44:09","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-498257/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-498257/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":9117020,"identity":"3c9be219-bfb9-42cf-995b-dcd7ce3c3e3b","added_by":"auto","created_at":"2021-05-13 00:18:33","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":560083,"visible":true,"origin":"","legend":"Venn Diagram","description":"","filename":"Fig1.Vennresult.png","url":"https://assets-eu.researchsquare.com/files/rs-498257/v1/f5c2dbce096d7855a4fc9a0a.png"},{"id":9116575,"identity":"2a4ffcdb-d88f-466b-a2cf-974a77de1039","added_by":"auto","created_at":"2021-05-13 00:15:32","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":41414,"visible":true,"origin":"","legend":"GO enrichment analysis of DEGs in ESCC samples.","description":"","filename":"Fig2.GOofDEGs.png","url":"https://assets-eu.researchsquare.com/files/rs-498257/v1/1bbbfb7036a0e6183198004e.png"},{"id":9117018,"identity":"339560e7-36ab-4b9d-bd70-a27d34f83a07","added_by":"auto","created_at":"2021-05-13 00:18:32","extension":"jpg","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":22808,"visible":true,"origin":"","legend":"PPI network of DEGs.\nUpregulated genes are marked in yellow; downregulated genes are marked in blue.\n","description":"","filename":"3.jpg","url":"https://assets-eu.researchsquare.com/files/rs-498257/v1/6a842e54081c85efa608b7d1.jpg"},{"id":9116578,"identity":"c8191c0c-5a23-45b1-98a8-de44a025762b","added_by":"auto","created_at":"2021-05-13 00:15:32","extension":"jpg","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":28961,"visible":true,"origin":"","legend":"Hub genes.","description":"","filename":"4.jpg","url":"https://assets-eu.researchsquare.com/files/rs-498257/v1/036044446399c53e35e44bc6.jpg"},{"id":9117019,"identity":"da27fcb9-eabd-416a-93a0-f41ac1a83240","added_by":"auto","created_at":"2021-05-13 00:18:32","extension":"jpg","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":29884,"visible":true,"origin":"","legend":"GO of hub genes.","description":"","filename":"5.jpg","url":"https://assets-eu.researchsquare.com/files/rs-498257/v1/fb7c68b41ed15934abe0ad7a.jpg"},{"id":13692539,"identity":"fd169fa1-3b30-4291-82cf-b31772b91cb3","added_by":"auto","created_at":"2021-09-17 12:43:59","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":532578,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-498257/v1/3d494e41-8a80-4af8-912b-c7e5e45cf3c5.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Review and screening of key genes in esophageal squamous cell carcinoma","fulltext":[{"header":"Introduction","content":"\u003cp\u003eEsophageal cancer is the eighth most common cancer and the sixth leading cause of cancer-related mortality in the world \u003csup\u003e1,2\u003c/sup\u003e. ESCC is the major histological type accounting for about 90% of the 456,000 incident esophageal cancers each year \u003csup\u003e3\u003c/sup\u003e. The 5-year survival rate for ESCC is about 18%, a number that reflects limited approaches of early diagnosis and treatment of ESCC \u003csup\u003e4\u003c/sup\u003e. Thus, there is a great need to further figure out the molecular mechanisms and to develop better diagnostic and therapeutic methods for ESCC. The pathogenesis of ESCC is believed to be a multi-step process and the genetic determinants remain elusive. Increasing evidence shows that gene mutation plays a key role in ESCC tumorigenesis and tumor progression. These genes include upregulated genes \u003cem\u003eADAM29\u003c/em\u003e, \u003cem\u003eAJUBA\u003c/em\u003e, \u003cem\u003eCBX4/8, CCND1(BCL1/PRAD1), EGFR(ERBB1), ERBB2(HER-2), FAM135B, FGFR1, KMT2D(MLL2/MLL4/ALR), MMP14, MYC, NOTCH, NRF2(NFE2L2), PIK3CA, RB1, SOX2, TP53, XPO1, YAP1 \u003c/em\u003eand downregulated genes \u003cem\u003eCDKN2A, CREBBP/EP300, CUL3, FAT1, FBXW7, KMT2C(MLL3), PTEN, TET2, TGFBR2, ZFP36L2, ZNF750\u003c/em\u003e \u003csup\u003e5-11\u003c/sup\u003e(Table 1). Genes involved in cell cycle, the Notch signaling pathway, epigenetic processes and RTK/PI3K/AKT circuit are frequently altered \u003csup\u003e12\u003c/sup\u003e. Cell cycle progression is changed mostly by\u0026nbsp;\u003cem\u003eTP53\u003c/em\u003e mutation, \u003cem\u003eCDKN2A\u003c/em\u003e deletion/mutation and \u003cem\u003eCCND1\u003c/em\u003e\u0026nbsp;amplification \u003csup\u003e5\u003c/sup\u003e. TP53 is the most significantly mutated genes (SMGs) in ESCC with mutation frequency reaching 93% \u003csup\u003e12\u003c/sup\u003e. NOTCH plays a dual role as both a tumor suppressor pathway and an oncogenic pathway, for which further studies are warranted \u003csup\u003e13\u003c/sup\u003e. Abudureheman et al. have shown that overexpression of \u003cem\u003eKMT2D\u003c/em\u003e facilitates ESCC tumor progression, and that it may exert oncogenic role via activation of epithelial-to-mesenchymal transition (EMT) \u003csup\u003e14\u003c/sup\u003e. In a large-sample study with ESCC in China \u003csup\u003e15\u003c/sup\u003e, \u003cem\u003ePIK3CA\u003c/em\u003e was significantly overexpressed in cancer tissue and its overexpression was independently associated with higher risk of local recurrence \u003csup\u003e15\u003c/sup\u003e. EGFR and FGFR1 were the most often amplified RTK/RAS-related genes in ESCC \u003csup\u003e9\u003c/sup\u003e, of which the inhibitors have been under therapeutic evaluation \u003csup\u003e16,17\u003c/sup\u003e. It\u0026rsquo;s worth noting that conflicting results were found in studies about prognostic value of TP53 overexpression in ESCC \u003csup\u003e18-21\u003c/sup\u003e, of which the biological functions were undoubted. In general, there are still significant gaps to fill to figure out the exact mechanism of carcinogenesis and to develop precision treatment means of ESCC.\u003c/p\u003e\n\u003cp\u003eGene chip or gene profile is an advanced gene detection technique that can quickly detect all the genes within the same sample at one time \u003csup\u003e22\u003c/sup\u003e. Last two decades have seen more and more studies of genetic alterations in cancers via microarray technology and bioinformatics analysis, which have helped us identify the differentially expressed genes (DEGs) and related pathways in ESCC. However, the results were always limited or inconsistent because of tissue or sample heterogeneity in independent studies, or the results were produced from a single cohort study. Thus, integrated bioinformatics analysis combined with gene profiling technique might be innovative and solve this disadvantage. In this work, we downloaded three microarray datasets GSE161533, GSE20347, GSE77861 from NCBI-Gene Expression Omnibus database (NCBI-GEO) (Available online: \u003ca href=\"https://www.ncbi.nlm.nih.gov/geo\"\u003ehttps://www.ncbi.nlm.nih.gov/geo\u003c/a\u003e) followed by DEGs identification via GEO2R analysis. Subsequently, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and protein-protein interaction (PPI) network analysis were conducted to help us understand the molecular mechanisms of carcinogenesis and progression of ESCC. In summary, 230 DEGs and 14 hub genes were found in this study, which may serve as potential biomarkers for individualized prevention, early diagnosis and precise treatment.\u003c/p\u003e\u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eTable1. Expression of significantly mutated genes (SMGs) and their functions in ESCC\u003c/span\u003e\u003c/p\u003e\u003cdiv align=\"center\" style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\n \u003ctable style=\"border: none;width:489.5pt;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif; color: black;\"\u003eGene Symbol\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cstrong\u003e\u003cspan style=\"color: black;\"\u003eExpression in ESCC\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cstrong\u003e\u003cspan style=\"color: black;\"\u003eFunction of the Product\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 20.25pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cstrong\u003e\u003cspan style=\"color: black;\"\u003eReference\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eADAM29\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eupregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003ea member of ADAM family which plays an important role in regulating cell-to-cell or cell-matrix interactions\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 19.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e6,23\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:18.75pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eAJUBA\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:18.75pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eupregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:18.75pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003efunctions as a regulator of the Hippo pathway\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 18.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003csup\u003e7,24\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:24.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eBAP1\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:24.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003elack study\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:24.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: rgb(33, 33, 33);\"\u003ea deubiquitinating enzyme involved in the regulation of cell growth\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 24pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: rgb(33, 33, 33);\"\u003e\u003csup\u003e25\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:31.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eCBX4/8\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:31.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eupregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:31.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003epromotes cell proliferation, colony formation,and cell invasion\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 31.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e8\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:35.9pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eCCND1\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003e(BCL1/PRAD1)\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:35.9pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eupregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:35.9pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eregulation of cell cycle\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 35.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e7,26\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eCDKN2A\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003edownregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eregulation of cell cycle\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 19.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e9\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:24.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eCREBBP\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:24.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003elack study\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:24.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eServes as global transcriptional coactivators and integrators of numerous signaling pathways\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 24pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e7\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:24.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eCUL3\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:24.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003edownregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:24.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003ecore component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 24pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e10,11\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:24.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eDCDC1\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:24.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003elack study\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:24.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003emicrotubule-binding protein which plays an important role in mediating dynein-dependent transport\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 24pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e11\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:21.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eEGFR(ERBB1)\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:21.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eupregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:21.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003estimulates proliferation of different cell types\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 21pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e27,28\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:21.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eEP300\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:21.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eupregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:21.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003efunctions as histone acetyltransferase and regulates transcription via chromatin remodeling\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 21pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e29\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:41.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eERBB2\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003e(HER-2/NEU/NGL/MLN19)\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:41.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eupregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:41.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eregulates cell growth and differentiation\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 41.7pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e30\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eFAM135B\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eupregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003epromotes cell proliferation likely through its direct interaction with growth factor GRN\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 19.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e6,23,31\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eFAT1\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003edownregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003einhibits cell proliferation and migration\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 19.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e32\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:24.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eFBXW7\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:24.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003edownregulated\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:24.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eone of the F-box proteins inducing the degradation of positive cell-cycle regulators\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 24pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e33-35\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:24.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eFGFR1\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:24.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eupregulated\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:24.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eregulation of cell proliferation, differentiation, migration, and angiogenesis\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 24pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e5,36\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:43.95pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eKDM6A(UTX)\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:43.95pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003elack study\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:43.95pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003ea histone demethylase essential for cellular reprogramming\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 43.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e37\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:28.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eKMT2C(MLL3)\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:28.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003edownregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:28.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eregulation of expression of genes involved in cell growth and migration\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 28.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e38\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:45.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eKMT2D\u003cbr\u003e\u0026nbsp;(MLL2/MLL4/ALR)\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:45.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eupregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:45.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003ehistone methyltransferase\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e7,14\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:45.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eMMP14\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:45.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eupregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:45.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eendopeptidase that degrades various components of the extracellular matrix\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e24\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:45.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eMYC\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:45.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eupregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:45.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003etranscription factor that binds DNA in a non-specific manner\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e39\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eNOTCH\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eupregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eregulation of squamous differentiation\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 19.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e13\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eNRF2(NFE2L2)\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eupregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003etranscription factor that plays a key role in the response to oxidative stress\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 19.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e40,41\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003ePIK3CA\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eupregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003ethe p110\u0026alpha; catalytic subunit of PI3K\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 19.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e15,42,43\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003ePTCH\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003elack study\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003ea key modulator of signaling in the Hh pathway\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 19.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e44\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003ePTEN\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003edownregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003ea phosphatase which inhibits cell migration, spreading and focal adhesions\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 19.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e45\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eRB1\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eupregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003einhibits cell migration and invasion\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 19.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e46\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:.5in;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eSOX2\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:.5in;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eupregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:.5in;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003etranscriptional regulator having crucial roles in maintenance of progenitor and neural stem cells and neuroendocrine differentiation\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 0.5in;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e8,47\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:.5in;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eTET2\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:.5in;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003edownregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:.5in;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003edioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 0.5in;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e48,49\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:24.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eTGFBR2\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:24.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003edownregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:24.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003ea key mediator of TGF-\u0026beta; signaling\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 24pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e50,51\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:30.75pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eTP53\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:30.75pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eupregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:30.75pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eregulation of cell cycle, apoptosis and DNA damage repairing\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 30.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e18-21\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:30.75pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eXPO1\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:30.75pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eupregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:30.75pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003emediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 30.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e5\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:30.75pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eYAP1\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:30.75pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003eupregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:30.75pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003ethe critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 30.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e24,52\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:30.75pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eZFP36L2\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:30.75pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003edownregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:30.75pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003ezinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 30.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e10\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:131.85pt;padding:0in 5.4pt 0in 5.4pt;height:33.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cem\u003e\u003cspan style=\"color: black;\"\u003eZNF750\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:101.95pt;padding:0in 5.4pt 0in 5.4pt;height:33.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003edownregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.4pt;padding:0in 5.4pt 0in 5.4pt;height:33.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan style=\"color: black;\"\u003etranscription factor involved in epidermis differentiation\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.3pt;padding: 0in 5.4pt;height: 33pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-family: Calibri, sans-serif; font-size: 15px;\"\u003e\u003cspan style=\"color: black;\"\u003e\u003csup\u003e53\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\u003cbr\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cstrong\u003eIdentification of DEGs in ESCC\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAfter analyzing with GEO2R with adj. P value \u0026lt; 0.01, |log FC| \u0026gt; 1, DEGs (1504 in \u003ca href=\"https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE161533\"\u003eGSE161533\u003c/a\u003e, 1680 in \u003ca href=\"https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi\"\u003eGSE20347\u003c/a\u003e and 972 in \u003ca href=\"https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi\"\u003eGSE77861\u003c/a\u003e) were identified. The intersection of three gene sets of DEGs contains 230 genes as shown in venn diagram (Fig.1), which consists of 144 upregulated genes and 86 downregulated genes between normal and ESCC tissues.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eGO and KEGG enrichment analysis of DEGs\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTo annotate the DEGs, GO and KEGG enrichment analysis were performed using DAVID, with P value\u0026lt;0.05 considered significant. GO analysis results (Fig.2) showed that changes in biological processes (BP) were mainly enriched in oxidation-reduction process, positive regulation of cell proliferation, cell-cell adhesion and inflammatory response. Changes in cellular components (CC) of DEGs were significantly enriched in cytoplasm, extracellular exosome, cytosol and extracellular space. Changes in molecular function (MF) of DEGs were enriched in calcium ion binding, protein homodimerization activity, cadherin binding involved in cell-cell adhesion and actin binding. And KEGG analysis showed that DEGs mainly enriched in transcriptional misregulation in cancer and p53 signaling pathway.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePPI network construction and hub genes identification\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003ePrediction of the functional interaction was conducted by STRING online and the PPI network of DEGs was constructed by Cytoscape (Fig.3). Subsequently, 14 hub genes were identified with MCODE score \u0026gt; 10 (Fig.4).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eHub gene analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAmong all hub genes, only ESPL1 is down-regulated. GO and KEGG analysis network of hub genes was performed using ClueGO (Fig.5). Result showed that hub genes were mainly enriched in positive regulation of mitotic cell cycle phase transition, regulation of cytokinesis and DNA replication origin binding. Subsequently, we conducted an extensive literature search on the hub genes.\u003c/p\u003e\n\u003cp\u003eAURKA, which is significantly overexpressed in various cancers including ESCC \u003csup\u003e54\u003c/sup\u003e has been reported to contribute to the malignant development of ESCC \u003csup\u003e55\u003c/sup\u003e and Jin et al. have revealed part of the mechanism underlying this process \u003csup\u003e56\u003c/sup\u003e. Ke et al. showed that downregulated CDC6 functioned as downstream molecule of RYBP in the inhibition of cell proliferation in ESCC \u003csup\u003e57\u003c/sup\u003e. An association between overexpression of \u003cem\u003eDTL\u003c/em\u003e and detrimental outcome in basal-like and luminal breast cancer and non-small cell lung adenocarcinomas but not esophagus-stomach cancer was found in another bioinformatic analysis \u003csup\u003e58\u003c/sup\u003e. The gene \u003cem\u003eECT2 \u003c/em\u003eencoding guanine nucleotide exchange factor (GEF) functions as an oncogene in a wide spectrum of cancers \u003csup\u003e59\u003c/sup\u003e. Sun et al. \u003csup\u003e60\u003c/sup\u003e showed that ECT2 promoted proliferation and metastasis of ESCC via the RhoA-ERK signaling pathway. And the overexpression of ECT2 often suggests a poor outcome in cancers, especially in breast cancer \u003csup\u003e61,62\u003c/sup\u003e , gastric cancer \u003csup\u003e63\u003c/sup\u003e, non-small-cell lung cancer \u003csup\u003e64,65\u003c/sup\u003e, and ESCC \u003csup\u003e65\u003c/sup\u003e. \u003cem\u003eESPL1\u003c/em\u003e, the dysregulation of which plays an important role in the development of aneuploidy \u003csup\u003e66\u003c/sup\u003e, is a candidate oncogene in luminal B breast cancers \u003csup\u003e67\u003c/sup\u003e. Studies have revealed the significant association between high expression of FOXM1 and poor outcome of ESCC \u003csup\u003e68,69\u003c/sup\u003e. GTSE1 was found to promote malignant behavior in hepatocellular carcinoma (HCC) \u003csup\u003e70\u003c/sup\u003e, confer to cisplatin resistance in gastric cancer cells \u003csup\u003e71\u003c/sup\u003e and to be involved in breast cancer progression \u003csup\u003e72\u003c/sup\u003e. Overexpression of \u003cem\u003eKIF14\u003c/em\u003e in ESCC was validated in a study, in which \u003cem\u003eKIF14\u003c/em\u003e was a downstream gene regulated by the\u0026nbsp;\u003cem\u003emiR-375/MMP13\u003c/em\u003e\u0026nbsp;axis \u003csup\u003e73\u003c/sup\u003e. The overexpression of MCM10 in ESCC has been confirmed in an experiment using semiquantitative reverse transcription-PCR \u003csup\u003e74\u003c/sup\u003e. MCM2, of which the diagnostic value has been confirmed in different types of cancers \u003csup\u003e75-77\u003c/sup\u003e was found to be a more reliable and useful marker than Ki67 in assessing tumor growth and tumor aggressiveness in patients with ESCC \u003csup\u003e78\u003c/sup\u003e and in screening patients at high risk of ESCC in mass surveys \u003csup\u003e79\u003c/sup\u003e. RFC4 has been found to be overexpressed in several cancers \u003csup\u003e80\u003c/sup\u003e, while study about its role in ESCC remains blank. \u003cem\u003eRRM1\u003c/em\u003e has been found to be an oncogene in lung cancer \u003csup\u003e81\u003c/sup\u003e, the overexpression of which is involved in tumor progression \u003csup\u003e82\u003c/sup\u003e and is transforming to the therapeutic target \u003csup\u003e83,84\u003c/sup\u003e. A large-scale, long-term follow-up retrospective analysis \u003csup\u003e85\u003c/sup\u003e showed that TOP2A expression was not only associated with perineural invasion and poorer differentiation, but it could be also an independent prognostic factor. Additionally, as TOP2A is a specific marker for the use of chemotherapeutic drugs such as anthracycline, therapy targeting TOP2A protein may be an appropriate way of individualized treatment and improving the prognosis of ESCC patients. Studies \u003csup\u003e86,87\u003c/sup\u003e using immunohistochemical analysis confirmed that UBE2C protein expression was upregulated in all ESCC cases, but absent in the histologically normal tumor surrounding tissues, pointing out its role as a diagnostic biomarker for ESCC. Besides, high expression of UBE2C is a marker of poor prognosis in ESCC \u003csup\u003e87\u003c/sup\u003e.\u003c/p\u003e\u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eTable2. Fuction and clinical significance of 14 hub genes with MCODE score \u0026ge;10.\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026ldquo;\u0026rarr;\u0026rdquo; indicates \u0026ldquo;was significantly associated with\u0026rdquo;\u003c/span\u003e\u003c/p\u003e\u003cp\u003e\u003cimg 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Efforts have been made to figure out the genetic events underlying its carcinogenesis and progression, but the molecular mechanisms of these processes remain elusive. To identify the candidate genes involved in ESCC, literature about significantly mutated genes (SMGs) was extensively reviewed and gene expression profiles of GSE161533, GSE20347 and GSE77861 were downloaded from the Gene Expression Omnibus (GEO) database. Following the identification of 230 differentially expressed genes (DEGs), hub gene identification was performed by the plug-in MCODE in Cytoscape software. 14 hub genes were identified which were enriched in cell cycle, DNA replication and p53 signaling pathway. In summary, genes mentioned in this study may provide potential targets for treatment and diagnosis of ESCC and help us better understand the pathogenesis and progression of ESCC from genetic perspective.","manuscriptTitle":"Review and screening of key genes in esophageal squamous cell carcinoma","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2021-05-13 00:15:30","doi":"10.21203/rs.3.rs-498257/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"b6474916-6d2d-461c-af6e-6dfdfe6f3ce1","owner":[],"postedDate":"May 13th, 2021","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":4270536,"name":"Cancer Biology"},{"id":4270537,"name":"Oncology"},{"id":4270538,"name":"Bioinformatics"},{"id":4270539,"name":"Computational Biology"}],"tags":[],"updatedAt":"2021-06-24T11:59:08+00:00","versionOfRecord":[],"versionCreatedAt":"2021-05-13 00:15:30","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-498257","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-498257","identity":"rs-498257","version":["v1"]},"buildId":"cBFmMYwuxLRRLfASyISRj","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}