TPE and conventional treatment in the management of hyperlipidemic acute pancreatitis: a Meta Analysis

Abstract Background The proportion of hypertriglyceridemic acute pancreatitis (HTG-AP) in acute pancreatitis is increasing year by year. The risk of AP occurrence and recurrence is positively related to triglyceride levels. At present, the application of therapeutic plasma exchange (TPE) in HTG-AP is gradually popularized, but there is no consensus on whether it can improve the mortality and prognosis of HTG-AP. Therefore, we aimed to compare the differences between TPE and conventional therapy in the treatment of HTG-AP. Methods Our study collected nearly 5 years of literature and analyzed the differences between TPE and conventional therapy in HTG-AP management by meta. Results The results show that TG could get a higher clearance rate within the first 24 hours by TPE, compared with conventional treatment (P = 0.001). However, TPE can not improve the prognosis of HTG-AP (P = 0.13), and even make patients suffer more time (P = 0.03) and money costs (P = 0.004). Discussion Conventional treatments can effectively manage HTG-AP without the need for TPE.