Development and Validation of a Nomogram for Evaluating the Prognosis of Immunotherapy plus Antiangiogenic Therapy in Non-small Cell Lung Cancer

Background: With the combination therapy of PD-1/PD-L1 antibody and antiangiogenic drugs used widely in clinic, a novel method to estimate the prognosis of patients is needed. We aimed to develop a nomogram to examine prognosis of anti-PD-1/PD-L1 antibody plus bevacizumab in non-small cell lung cancer (NSCLC) patients. Methods: : We developed a nomogram using the cohort involving 204 NSCLC patients who treated with immunotherapy and anti-angiogenesis therapy. The nomogram was validated under the same conditions in another cohort with 69 patients. Prognostic factors were assessed using Cox regression analysis. The nomogram was internally validated using bootstrap resampling and then externally validated. Performance was assessed using concordance index, calibration curve and decision curve analysis. Clinical utility was evaluated using receiver operation characteristic curve. Results: : Pleural metastasis (P=0.001, HR=2.980, 95%CI=1.521-5.837), ANC (P<0.001, HR=5.139, 95%CI=2.081-12.691), ALC (P=0.010, HR=0.331, 95%CI=0.142-0.771), B cells (P=0.005, HR=0.329, 95%CI=0.151-0.714), Treg cells (P=0.002, HR=2.934, 95%CI=1.478-5.826) were independent prognostic factors. The calibration curves showed a good consistency and the C-index of nomogram were 0.808, 0.741 in training and external validation cohort, respectively. The area under the curve (AUC) in receiver operation characteristic curves (ROC) are 0.833 (P<0.001) and 0.908 (P<0.001), respectively. Conclusion: We build an accurate and convenient nomogram to predict long-time overall survival (OS) of NSCLC patients treated with PD-1/PD-L1 antibody and antiangiogenic drugs and validated this nomogram. The nomogram might be helpful to clinicians to estimate long-time OS of NSCLC patients treated with PD-1/PD-L1 antibody and antiangiogenic drugs.