PRINCIPLES OF CONSERVATIVE THERAPY TAKING INTO ACCOUNT LOCALIZATION OF ENDOMETRIOITIC GETHEROTOPIAS

Н. А. Щербина, E. P. Gnatko, Liliya Potapova, Ирина Николаевна Щербина, Оксана Петрівна Ліпко
In: Neonatology, surgery and perinatal medicine · 2018 · vol. 8(3(29)) , pp. 55–61 · doi:10.24061/2413-4260.viii.3.29.2018.10 · W2899303508
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Differentiated hormonal and immunological treatment of endometriosis based on localization and disease severity, compared to traditional therapy, showed faster pain reduction, earlier reproductive function restoration, and reduced relapses.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

The paper examines mechanisms of pathogenesis and proposes a rational conservative treatment strategy for genital endometriosis that accounts for the localization of endometrioid heterotopias, as well as features of immune and hormonal homeostasis. The authors studied 115 patients with external and internal endometriosis stages I–II and III–IV, comparing traditional conservative treatment in 57 patients versus differentiated hormonal and immunologic treatment guided by lesion localization in 58 patients. They report that immune alterations appear secondary, with changes increasing alongside disease spread, and that both immune reactivity and local hormonal homeostasis differ depending on lesion localization and severity. The differentiated conservative approach was associated with faster pain reduction and earlier recovery of reproductive function, and with fewer recurrences (claimed 1.5–2-fold reduction) versus traditional therapy. This paper is centrally about endometriosis — conservative therapy is designed around localization of endometrioid heterotopias and corresponding immune and hormonal homeostasis.

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Abstract

Introduction. In work the principles of conservative therapy of patients taking into account localization of endometriotic heterotopias, features of immune and hormonal homeostasis are represented.The study of the mechanisms genital endometriosis of pathogenic of different forms and degrees distribution was the purpose of work and development of rational medical tactic of the efficiency of medical treatment and rehabilitation of patients directed on the increase.Materials and methods. 115 patients with I-II outward and internal endometriosis are inspected, III-IV degrees of distribution. to 57 (49,6%) patients traditional conservative medical treatment of endometriosis was conducted. 58 (50,4%) patients got the differentiated hormonal and immunological medical treatment taking into account localization of endometriosis.Research results. The conducted researches showed that violations in a state of general immunity at patients with different clinical forms of endometriosis carried the second character, what the dynamics of growth of changes in immune status specifies on by a patient with growth of degree of distribution of disease, and also presence of substantial differences in general immunological reactivity depending on localization of endometriosis. Hormonal local homeostasis also has certain differences depending on localization and degree of weight of process, and it is needed to take into account during conducting of pathogenesis medical treatment of endometriosis with different localization.Conclusions. The conducted study of therapeutic efficiency of the differentiated medical treatment taking into account localization and degree of distribution of process showed more rapid decline of pain syndrome, and also more early renewal of reproductive function. Conservative therapy of endometriosis was conducted taking into account localization of endometriotic heterotopias of features of homeostasis (immune and hormonal) results in a clinical effect more early and stable, on comparison with traditional therapy, is instrumental in reduction of relapses of endometriosis in 1,5-2 times.

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endometriosis

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last seen: 2026-06-10T17:14:06.276822+00:00
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