False-positive diagnosis of uterine malignancy with raised 18F-fluorodeoxyglucose activity in adenomyosis: A case report

Wong, Wu Shun Felix, Kwok To Thomas Li
2022 · doi:10.5281/zenodo.6349819 · W6931730755
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This case report describes a patient with adenomyosis who received a false-positive diagnosis of uterine malignancy due to elevated 18F-fluorodeoxyglucose uptake on PET-CT, highlighting the need for clinical awareness.

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⚙ AI-generated deep summary by qwen3.7-flash, 2026-09-02 · read from full text ⓘ

This case report describes a patient with adenomyosis who presented with elevated 18F-fluorodeoxyglucose uptake on PET-CT imaging, initially mimicking uterine malignancy. The authors highlight that benign conditions like adenomyosis can cause significant FDG activity, potentially leading to false-positive diagnoses and unnecessary surgical interventions. The paper emphasizes the importance of clinical awareness regarding this diagnostic pitfall to avoid misinterpretation of imaging results in patients with known or suspected benign uterine pathology. Relevance to endometriosis: This paper is centrally about adenomyosis, which is often considered part of the same spectrum of disorders as endometriosis, though it does not explicitly discuss endometriosis lesions.

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Abstract

Positron Emission Tomography - Computed Tomography (PET-CT) has been used to diagnose malignancy before surgery. However, there may be an increase in 18F-fluorodeoxyglucose (FDG) uptake in PET scans in benign conditions, leading to a false-positive diagnosis of malignancy and unnecessary surgery. This PET-CT investigation is expensive and is not without risk, including radiation and drug or contrast hypersensitivity. Although variable uterine uptakes of FDG activities in PET-CT had been reported in the literature, unawareness of its possibility in benign conditions could lead to a false alarm of malignancy. This paper reported a patient with a false-positive FDG finding presenting as a malignant uterine lesion for surgery, aiming to raise the clinical awareness of this finding.
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False-positive diagnosis of uterine malignancy with raised 18F-fluorodeoxyglucose activity in adenomyosis: A case report Authors/Creators - 1. Department of Obstetrics and Gynaecology, School of Women's and Children's Health, The University of New South Wales, Sydney, Australia. - 2. Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, China. Description Positron Emission Tomography - Computed Tomography (PET-CT) has been used to diagnose malignancy before surgery. However, there may be an increase in 18F-fluorodeoxyglucose (FDG) uptake in PET scans in benign conditions, leading to a false-positive diagnosis of malignancy and unnecessary surgery. This PET-CT investigation is expensive and is not without risk, including radiation and drug or contrast hypersensitivity. Although variable uterine uptakes of FDG activities in PET-CT had been reported in the literature, unawareness of its possibility in benign conditions could lead to a false alarm of malignancy. This paper reported a patient with a false-positive FDG finding presenting as a malignant uterine lesion for surgery, aiming to raise the clinical awareness of this finding. Files WJARR-2022-0178.pdf Files (960.9 kB) | Name | Size | Download all | |---|---|---| | md5:53440d2936a7f9b6ad8c7992edad0a55 | 960.9 kB | Preview Download |

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