Risk factors of dermatomyositis complicated with interstitial pneumonia

Aim: To investigate the clinical characteristics and related risk factors of dermatomyositis(DM) complicated with interstitial pneumonia(ILD). Methods The clinical data of 105 patients with dermatomyositis were hospitalized in the respiratory department or rheumatic Immunology Department of the First Affiliated Hospital of Harbin Medical University from January 2018 to December 2021 and underwent pulmonary imaging examination were retrospectively analyzed. The hospital medical record room records were used as the data source, including 55 cases in the DM-ILD group and 50 cases in DM without the ILD group as the control group. Results there were significant differences in ESR, C-reactive protein, KL-6, cough, chest tightness/shortness of breath, and Velcro rale between the two groups (P < 0.05); Multivariate logistic regression analysis showed that the increase of KL-6 was an independent risk factor for DM-ILD. Conclusion the increase of KL-6 in patients with dermatomyositis should be vigilant against ILD occurrence.