Genomic analyses identify biological processes of pancreatic cancer after radiotherapy

Radiotherapy is a crucial component in the treatment of pancreatic cancer such as pancreatic ductal adenocarcinoma (PDAC). However, the key molecules and mechanisms are not fully understood. In this study, our objective is to identify the significant molecules and potential signaling pathways in the processes of PDAC after radiotherapy by analyzing the RNA sequence. The GSE185311 dataset was created by using the Illumina NovaSeq 6000 (Homo sapiens). The KEGG and GO analyses indicated that "apoptosis", "TNF signaling", and "NF-κB signaling" are the main functional processes during radiotherapy. Moreover, we determined numerous genes including FDXR, DDB2, LY6H, ZMAT3, GPR174, LYNX1, CD300C, SPATA18, HLA-DQB1, and CEND1 by using the String and PPI network. Thus, our study may guide the clinical work on the treatment of PDAC through radiotherapy.