Knowledge Mapping of Clec9a on dendritic cells: A Review and Bibliometric Study (2008–2024)

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Background: Clec9a (also named as DNGR-1), is a restricted DAMPs (Damage-Associated Molecular Patterns) receptor that recognizes cell death signals expressed on human BDCA3 + DC and mouse CD8α + and CD103 + DC. With the rapid advancement of immunology, numerous studies of Clec9a have been published. However, no relevant bibliometric studies have been published to date. This study aims to provide a comprehensive understanding of the current state of research and identify potential new research directions via a bibliometric analysis of Clec9a. Methods: : Publications related to Clec9a from 2008 to 2024 were retrieved by the Web of Science Core Collection (WoSCC). The three software (VOSviewer, CiteSpace and Bibliometrix) are to assess the contribution and co-occurrence relationships of various countries, institutions, journals and authors, and to explore research hotspots and future trends in this field. Results: : A total of 240 English articles from various countries published between 2008-2024 were identified, with an increasing trend in the number of publications each year. The top three contributing countries were USA, Australia, and UK, accounting for 22.50%, 21.25%, and 20.00%, Respectively. The University of Melbourne contributed the most with 32 papers (13.33%). Lahoud, Mireille H, with 32 articles, ranked first amongst authors in terms of publications and Sancho, D. with 188 co-citations, was the amongst co-cited authors. Frontiers in Immunology was influential academic journal in Clec9a research. The aggregation and identification of key nodes in the co-citation network revealed a shift in the focus of Clec9a research. Initially, the hotspot areas were primarily ”antibody formation,” ”systems biology,” ”BDCA3,” and ”langerin,” while in recent years, the focus has shifted to ”vaccines” and ”autophagy.” Conclusion: This is the first bibliometric study to provide a comprehensive summary of the research trends and developments of Clec9a. Currently, the most active frontiers focus on better understanding the role and clinical applications of Clec9a in tumor immunotherapy and DC-targeted vaccination in viral diseases.
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Knowledge Mapping of Clec9a on dendritic cells: A Review and Bibliometric Study (2008–2024) | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 25 April 2025 V1 Latest version Share on Knowledge Mapping of Clec9a on dendritic cells: A Review and Bibliometric Study (2008–2024) Authors : Liu Fang , Yang Xingkai , Sun Yixuan , Zhao Wei , and Zhongyi Yan 0000-0002-9835-5875 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174559699.95505486/v1 259 views 133 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background: Clec9a (also named as DNGR-1), is a restricted DAMPs (Damage-Associated Molecular Patterns) receptor that recognizes cell death signals expressed on human BDCA3 + DC and mouse CD8α + and CD103 + DC. With the rapid advancement of immunology, numerous studies of Clec9a have been published. However, no relevant bibliometric studies have been published to date. This study aims to provide a comprehensive understanding of the current state of research and identify potential new research directions via a bibliometric analysis of Clec9a. Methods: Publications related to Clec9a from 2008 to 2024 were retrieved by the Web of Science Core Collection (WoSCC). The three software (VOSviewer, CiteSpace and Bibliometrix) are to assess the contribution and co-occurrence relationships of various countries, institutions, journals and authors, and to explore research hotspots and future trends in this field. Results: A total of 240 English articles from various countries published between 2008-2024 were identified, with an increasing trend in the number of publications each year. The top three contributing countries were USA, Australia, and UK, accounting for 22.50%, 21.25%, and 20.00%, Respectively. The University of Melbourne contributed the most with 32 papers (13.33%). Lahoud, Mireille H, with 32 articles, ranked first amongst authors in terms of publications and Sancho, D. with 188 co-citations, was the amongst co-cited authors. Frontiers in Immunology was influential academic journal in Clec9a research. The aggregation and identification of key nodes in the co-citation network revealed a shift in the focus of Clec9a research. Initially, the hotspot areas were primarily ”antibody formation,” ”systems biology,” ”BDCA3,” and ”langerin,” while in recent years, the focus has shifted to ”vaccines” and ”autophagy.” Conclusion: This is the first bibliometric study to provide a comprehensive summary of the research trends and developments of Clec9a. Currently, the most active frontiers focus on better understanding the role and clinical applications of Clec9a in tumor immunotherapy and DC-targeted vaccination in viral diseases. Supplementary Material File (ms-bibliometric analysis of research on clec9a.docx) Download 207.80 KB File (table.docx) Download 87.56 KB Information & Authors Information Version history V1 Version 1 25 April 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords dendritic cells tumour immunology vaccination Authors Affiliations Liu Fang Henan University School of Basic Medical Sciences View all articles by this author Yang Xingkai Henan University School of Basic Medical Sciences View all articles by this author Sun Yixuan Henan University School of Basic Medical Sciences View all articles by this author Zhao Wei Henan University School of Basic Medical Sciences View all articles by this author Zhongyi Yan 0000-0002-9835-5875 [email protected] Henan University School of Basic Medical Sciences View all articles by this author Metrics & Citations Metrics Article Usage 259 views 133 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Liu Fang, Yang Xingkai, Sun Yixuan, et al. Knowledge Mapping of Clec9a on dendritic cells: A Review and Bibliometric Study (2008–2024). Authorea . 25 April 2025. 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