Relation between Bcl-2/FasL gene and pathogenesis of endometriosis

Objective:To research whether the endometriosis is associated with Bc1-2 and FasL gene.Methods:Immunohistochemistry method (streptavidin-peroxidase method) was used to detect the expression of Bcl-2 and FasL gene in 19 specimens of normal endometrium tissue,33 specimens of endometriosis tissue and eutopic endometrium from patients with endometriosis (11 cases).Results:①The control group : the expression of Bcl-2 and FasL predominated in the glandular cytoplasm and/or on the plasma membrane. The expressions of Bcl-2 in proliferative phase was higher than that in secretory phase significantly (P0. 05). The expressions of FasL in proliferative phase was less than that in secretory phase significantly (P0. 05). So the expressions of Bcl-2 and FasL obviously cyclic changes throughtout the menstrual cycle in nomal endometrium tissue. ②The endometriosis group: The expressions of Bcl-2 and FasL also predominated in the glandular cytoplasm and/or on the plasma membrane. Both Bcl-2 and FasL expression in proliferative phase was the same as secretory phase (P0.05). So Bcl-2 and FasL expression in adenomyosis had no cyclic change and their staining had remained in the whole menstrual cycle. The expressions of Bcl-2 and FasL in endometriosis was higher than that in normal endometrium significantly (P0.000 1).Conclusion:The retrograding of these active anti-apoptotic endometrial cells may play a key role in the pathogenesis of endometriosis.