Route Efficiency Assessment and Review of the Synthesis of β-Nucleosides via N-Glycosylation of Nucleobases

2020 · doi:10.26434/chemrxiv.12753413.v1
preprint OA: closed CC-BY-NC-ND-4.0
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Abstract

Instead of focusing on maximizing glycosylation yield, future syntheses of nucleosides via N-glycosylation should aim to use shorter routes, fewer protecting groups and less chromatography to achieve more efficient and sustainable processes, as this E-factor analysis reveals.

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License: CC-BY-NC-ND-4.0