The Effect of Helicobacter Pylori Eradication On Prognosis Of Postoperative Early Gastric Cancer: A Multicenter Study

Abstract Objective: To investigate the effect of Helicobacter pylori (H. pylori) eradication on the prognosis of postoperative early gastric cancer (EGC).Methods: This is a retrospective study based on data from 6 hospitals. We identified patients with EGC who underwent curative gastrectomy from January 2010 to December 2016. All of the patients were tested for H. pylori. Patients were divided into two groups, the successful H. pylori eradication group (Group A) and the non-H. pylori eradication group (Group B), for calculating the disease-free survival (DFS) and overall survival (OS) of each group.Result: Non-H. pylori eradication were statistically significant independent risk factors of overall survival (hazard ratio (HR), 1.760; 95% confidence interval (CI), 1.067-2.902; P=0.027) and disease-free survival (HR, 1.728; 95% CI, 1.077-2.772; P=0.023).Conclusion: Eradication treatment for H. pylori can prevent the recurrence of postoperative early gastric cancer.