Diagram of experimental protocols.

Annelyn Torres-Reverón (5650028), Maahrose Rana (8298858), Varesh Gorabi (8298861), Leslie L. Rivera-Lopez (5963024), Caroline B. Appleyard (5650037)
2020 · doi:10.1371/journal.pone.0227456.g001 · W6904641063
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This study utilized two cohorts of rats to investigate the effects of short-term antalarmin treatment on adrenal gland receptors within an experimental model of endometriosis. The first cohort underwent either endometriosis-inducing or sham surgery and was observed for seven days, while the second cohort received antalarmin or a vehicle following endometriosis surgery with observation extending to day sixty. Baseline comparisons were established using untreated sham rats from the second group to ensure accurate assessment of receptor alterations. This paper is centrally about endometriosis — specifically examining the impact of antalarmin on adrenal gland receptors in a rat model of the condition.

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Abstract

The protocol for tissue collection used in the current manuscript is similar to the one previously published [22]. Two separate cohorts of rats were used: one that received endometriosis or sham surgery and allowed to progress until 7 days after surgery, and one that received antalarmin or vehicle with endometriosis surgery which was allowed to progress until day 60. Sham rats in group 2 did not receive any treatment and were used for baseline comparisons.
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Short treatment with antalarmin alters adrenal gland receptors in the rat model of endometriosis Fig 1 Diagram of experimental protocols. The protocol for tissue collection used in the current manuscript is similar to the one previously published [22]. Two separate cohorts of rats were used: one that received endometriosis or sham surgery and allowed to progress until 7 days after surgery, and one that received antalarmin or vehicle with endometriosis surgery which was allowed to progress until day 60. Sham rats in group 2 did not receive any treatment and were used for baseline comparisons.

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endometriosis

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