Analysis of the Correlation Between Pregnancy Complications and Placental Histopathology: A Study of Samples from Shahid Sadoughi Hospital, Yazd, Iran (2013-2022)

Analysis of the Correlation Between Pregnancy Complications and Placental Histopathology: A Study of Samples from Shahid Sadoughi Hospital, Yazd, Iran (2013-2022) | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Analysis of the Correlation Between Pregnancy Complications and Placental Histopathology: A Study of Samples from Shahid Sadoughi Hospital, Yazd, Iran (2013-2022) Alireza Torki This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5863899/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Aims : This study aimed to investigate the correlation between pregnancy complications and placental histopathology in samples collected at Shahid Sadoughi Hospital in Yazd from 2013 to 2022. Method : A census sampling approach was utilized to examine all placental samples submitted to the pathology department at Shahid Sadoughi Hospital between 2012 and 2014. Following approval from the Research Council of the Faculty of Medicine at Shahid Sadoughi University of Medical Sciences in Yazd and clearance from the ethics committee, the study commenced. Stakeholders were briefed on the study objectives, methodology, and 15 data confidentiality. Patient records were scrutinized based on predefined criteria, and relevant information was extracted. Results : The retrospective analysis included 210 subjects with an average age of 28.78±5.51 years. The average gestational age in the sampled cases was 32.98±4.09 weeks. The highest incidence of pregnancy-related pathologies was attributed to IUGR at 20.0% and IUFD at 18.1%. The predominant placental histopathological findings were categorized as no significant abnormalities (26.2%) and multifocal ischemic changes (21.0%). Conclusion : The study findings establish a significant association between pregnancy complications like IUGR and IUFD and specific placental histopathological patterns. Notably, a substantial proportion of cases exhibited diverse placental histopathologies, particularly those with unremarkable findings and multiple ischemic changes. These results underscore the importance of diligent placental histopathological assessments in the investigation of pregnancy complications, aiding in enhanced clinical decision-making. The study recommends comprehensive placental histopathological evaluations in suspected high-risk pregnancies to improve clinical management strategies Pathology Pregnancy complications Placental histopathology Pathology IUGR IUFD Full Text Additional Declarations The authors declare no competing interests. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-5863899","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":408653398,"identity":"e56f8576-2540-432f-bdcf-da92fa3d3491","order_by":0,"name":"Alireza Torki","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAyElEQVRIiWNgGAWjYBACAwYeMC1n397AwEyClgQGYwOeAyRqSTSQSCBSizl778HHvD8YEswl3xh+LqiwYeBv707Aq8Wy51yyMU8CQ57l7Bxj6Rln0hgkzpzdgN9hN3LMpIFaihlu5xhI87YdZjCQyCVOS2LDzTPGv0nTsuEGjxmRtpw5l2w4J43BWLInrcya50waD2G/HO89+OCNDYMcP/vhzbd5Kmzk+Nt78WuBgv9AzGEAYvEQoxwG2B+QonoUjIJRMApGEAAAu35CGaJRuSYAAAAASUVORK5CYII=","orcid":"","institution":"Iran university of medical scinse","correspondingAuthor":true,"prefix":"","firstName":"Alireza","middleName":"","lastName":"Torki","suffix":""}],"badges":[],"createdAt":"2025-01-20 08:22:31","currentVersionCode":1,"declarations":{"humanSubjects":false,"vertebrateSubjects":true,"conflictsOfInterestStatement":false,"humanSubjectEthicalGuidelines":false,"humanSubjectConsent":false,"humanSubjectClinicalTrial":false,"humanSubjectCaseReport":false,"vertebrateSubjectEthicalGuidelines":true},"doi":"10.21203/rs.3.rs-5863899/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-5863899/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":75061785,"identity":"8be94bb9-5fca-42e4-861c-a0a210d91341","added_by":"auto","created_at":"2025-01-30 04:35:45","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":245314,"visible":true,"origin":"","legend":"","description":"","filename":"Manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-5863899/v1_covered_e65221cf-92d3-44e6-a195-0c8f6e54ca51.pdf"}],"financialInterests":"The authors declare no competing interests.","formattedTitle":"\u003cp\u003eAnalysis of the Correlation Between Pregnancy Complications and Placental Histopathology: A Study of Samples from Shahid Sadoughi Hospital, Yazd, Iran (2013-2022)\u003c/p\u003e","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"Iran University of Medical Sciences","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Pregnancy complications, Placental histopathology, Pathology, IUGR, IUFD ","lastPublishedDoi":"10.21203/rs.3.rs-5863899/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-5863899/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eAims\u003c/strong\u003e: This study aimed to investigate the correlation between pregnancy complications and placental histopathology in samples collected at Shahid Sadoughi Hospital in Yazd from 2013 to 2022.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethod\u003c/strong\u003e: A census sampling approach was utilized to examine all placental samples submitted to the pathology department at Shahid Sadoughi Hospital between 2012 and 2014. Following approval from the Research Council of the Faculty of Medicine at Shahid Sadoughi University of Medical Sciences in Yazd and clearance from the ethics committee, the study commenced. Stakeholders were briefed on the study objectives, methodology, and 15 data confidentiality. Patient records were scrutinized based on predefined criteria, and relevant information was extracted.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults\u003c/strong\u003e: The retrospective analysis included 210 subjects with an average age of 28.78±5.51 years. The average gestational age in the sampled cases was 32.98±4.09 weeks. The highest incidence of pregnancy-related pathologies was attributed to IUGR at 20.0% and IUFD at 18.1%. The predominant placental histopathological findings were categorized as no significant abnormalities (26.2%) and multifocal ischemic changes (21.0%).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion\u003c/strong\u003e: The study findings establish a significant association between pregnancy complications like IUGR and IUFD and specific placental histopathological patterns. Notably, a substantial proportion of cases exhibited diverse placental histopathologies, particularly those with unremarkable findings and multiple ischemic changes. These results underscore the importance of diligent placental histopathological assessments in the investigation of pregnancy complications, aiding in enhanced clinical decision-making. 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