Effects of 400 Hz cortico-cerebellar transcranial pulsed current stimulation montages on brain excitability and hand dexterity: a double-blind single-session trial

Effects of 400 Hz cortico-cerebellar transcranial pulsed current stimulation montages on brain excitability and hand dexterity: a double-blind single-session trial | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 30 April 2025 V1 Latest version Share on Effects of 400 Hz cortico-cerebellar transcranial pulsed current stimulation montages on brain excitability and hand dexterity: a double-blind single-session trial Authors : Shapour Jaberzadeh 0000-0003-2957-4510 [email protected] , Renming Liu , Mona Malekahmad 0000-0003-1546-2817 , and Maryam Zoghi Authors Info & Affiliations https://doi.org/10.22541/au.174599868.88597001/v1 250 views 129 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract backend=biber, style=alphabetic, sorting=ynt ]biblatex Objectives: This study compares the effects of two bifocal single session 400 Hz pulsed current stimulation (tPCS) montages, anodal tPCS over M1 with cathodal tPCS over the CB (a-tPCS M1 –c-tPCS CB ; Montage 1) and cathodal tPCS over M1 with anodal tPCS over the CB (c-tPCS M1 –a-tPCS CB ; Montage 2), on corticospinal excitability (CSE), corticocortical excitability (CCE), and hand dexterity. The findings aim to inform neuromodulation strategies for motor rehabilitation. Methods This double-blinded, randomized, counterbalanced crossover trial included 26 healthy young participants, each completing three sessions: Montage 1, Montage 2, and sham stimulation. Data were collected before and immediately after each stimulation session, with a minimum 48-hour washout period to prevent carryover effects. CSE and CCE were assessed using transcranial magnetic stimulation (TMS), while hand dexterity was evaluated using the Purdue Pegboard Test (PPT). Results A single session of Montage 1 (a-tPCS M1 –c-tPCS CB ) significantly enhanced CSE and improved motor performance, as demonstrated by faster completion times on the PPT (p 0.05). Conclusions These findings suggest that Montage 1 enhances CSE and hand dexterity, supporting its potential application in motor rehabilitation. The primary mechanisms underlying this increase in CSE were enhanced facilitation and reduced inhibition. In contrast, Montage 2 decreased CSE but did not lead to significant changes in hand dexterity, emphasizing the need for further investigation into its neuromodulatory mechanisms and potential clinical applications. The reduction in facilitation and increased inhibition were the key factors contributing to the decrease in CSE. Supplementary Material File (400 hz tpcs_anodal and cathodal m1-cb stimulation_final 28th march.docx) Download 1.37 MB Information & Authors Information Version history V1 Version 1 30 April 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Authors Affiliations Shapour Jaberzadeh 0000-0003-2957-4510 [email protected] Monash University Department of Physiotherapy View all articles by this author Renming Liu Monash University Department of Physiotherapy View all articles by this author Mona Malekahmad 0000-0003-1546-2817 Monash University Department of Physiotherapy View all articles by this author Maryam Zoghi Federation University Australia - Gippsland Campus View all articles by this author Metrics & Citations Metrics Article Usage 250 views 129 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Shapour Jaberzadeh, Renming Liu, Mona Malekahmad, et al. Effects of 400 Hz cortico-cerebellar transcranial pulsed current stimulation montages on brain excitability and hand dexterity: a double-blind single-session trial. Authorea . 30 April 2025. 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