Synthesis, Characterization, Antimicrobial Assessments, Potential Antioxidant and Molecular Docking Studies of Polyfunctional Substituted Azoles, Azines, and their Analogs linked Sulfamethoxazole moiety

Synthesis, Characterization, Antimicrobial Assessments, Potential Antioxidant and Molecular Docking Studies of Polyfunctional Substituted Azoles, Azines, and their Analogs linked Sulfamethoxazole moiety | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Synthesis, Characterization, Antimicrobial Assessments, Potential Antioxidant and Molecular Docking Studies of Polyfunctional Substituted Azoles, Azines, and their Analogs linked Sulfamethoxazole moiety I. A. Mousa, A. M. Elmaghraby, Hatem E. Gaffer, M. E. Yahya, Abdallah. M. A Hassane, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4674628/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract A new series of substituted azoles, azines, and their analogs linked sulfamethoxazole moiety was designed and synthesized. The antioxidant activity study of our synthesized compounds and molecular docking enhancement were achieved. Moreover, the antimicrobial assay indicated that compound 1 is the most active compound against all the strains compared to the reference drugs. So, reactions of β-oxobutanamide derivative 1 with different reagents afforded compounds 2a,b, 5, 7, 8, 12 and 14. Coupling of 1 with diazonium salt yield aryl hydrazones 10a,b which reacts with ethyl chloroformate to yield the triazinediones 11a,b. Reactions of enaminone 12 with some electrophilic and nucleophilic reagents to yield compounds 16, 21, 22, 23, 24 and 25 respectively. The structures of newly synthesized compounds were characterized by spectral and elemental analyses. Biological sciences/Molecular biology Physical sciences/Chemistry Full Text Additional Declarations No competing interests reported. Supplementary Files syblementrydataeltybfinalrevised1.docx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4674628","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":332723405,"identity":"7ef0a472-3893-472b-a072-f61fd78e0378","order_by":0,"name":"I. A. 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