Inhibitory Effect of Domestic Nafarelin on Endometrial Explant in Rats and Rabbits

The inhibitory effect of domestic nafarelin(Naf) on the growth of endometrial explant was studied, and compared with leuprolide (Leu) and danazol in rat and rabbit model of endometriosis. The results showed that subcutaneous injection of Naf 0.5, 1.5, 5 μg/kg and intranasal administration of Naf 30, 100 μg/kg could produce dose dependent inhibitory effect on the growth of endometrial explant in rats and rabbits. The inhibitory effect was more potent than that of Leu and danazol. The relative potency of inhibitory effect of Naf to Leu on the growth of endometrial explant were 5.47∶1 in rats, and 10.5∶1 in rabbits, respectively.