Sensitivity to direction and velocity of fast frequency chirps in the inferior colliculus of awake rabbit

Neurons in the mammalian inferior colliculus (IC) are sensitive to the velocity (speed and direction) of fast frequency chirps contained in Schroeder-phase harmonic complexes (SCHR). However, IC neurons are also sensitive to stimulus periodicity, a prominent feature of SCHR stimuli. Here, to disentangle velocity sensitivity from periodicity tuning, we introduced a novel stimulus consisting of aperiodic random chirps. Extracellular, single-unit recordings were made in the IC of Dutch-belted rabbits in response to both SCHR and aperiodic chirps. Rate-velocity functions were constructed from aperiodic-chirp responses and compared to SCHR rate profiles, revealing interactions between stimulus periodicity and neural velocity sensitivity. A generalized linear model analysis demonstrated that periodicity tuning influences SCHR response rates more strongly than velocity sensitivity. Principal component analysis of rate-velocity functions revealed that neurons were more often sensitive to the direction of lower-velocity chirps and were less often sensitive to the direction of higher-velocity chirps. Overall, these results demonstrate that sensitivity to chirp velocity is common in the IC. Harmonic sounds with complex phase spectra, such as speech and music, contain chirps, and velocity sensitivity would shape IC responses to these sounds. Highlights IC neurons had diverse sensitivity to chirp velocity (speed and direction) of periodic and aperiodic-chirp stimuli. Both velocity and periodicity sensitivity were necessary to predict neural responses to Schroeder-phase harmonic complexes. Neurons were more commonly sensitive to the direction of chirps at lower-speeds (e.g., 2 kHz/ms) in the tested range. The chirp speeds for which IC neurons were most sensitive are present in common harmonic sounds with realistic phase spectra, such as speech and music.