Sex chromosome mechanisms in cardiac development and disease

Many human diseases show differences between men and women in pathology and treatment outcomes. In cardiac disease, sex differences occur in the frequency of specific types of congenital and adult-onset heart disease. Clinical studies have suggested that gonadal hormones are a factor in sex bias. However, recent research has shown that gene and protein networks under non-hormonal control also account for cardiac sex differences. In this review, we describe the sex chromosome pathways that lead to sex differences in the development and function of the heart and highlight how these findings affect future care and treatment of cardiac disease.