Ionically Complexed Nanoparticles for Heparin Oral Delivery

Abstract Ionically complexed nanoparticles were prepared from an anionic polysaccharide drug, heparin, entrapped by a positively charged chitosan polysaccharide. In this study, the encapsulation of heparin was studied to optimize properties needed for its oral drug delivery. Chitosan, used in a variety of biomedical applications, was selected as a cationic polymer for heparin encapsulation. These particles were prepared with a slightly positive charge and an appropriate size for oral drug delivery. The release profiles of these ionically complexed nanoparticles were improved by using FDA approved stabilizers, such as pluronic non-ionic surfactant and polyvinyl alcohol. These results obtained in vitro suggest that these stabilized, ionically complexed nanoparticles may be well-suited for the oral drug delivery of heparin into the gastrointestinal tract.