[Drug therapy of endometriosis]

H Husslein, Husslein H
Archiv fur Gynakologie · 1969 · doi:10.1007/BF00683070 · PMID:5819947
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This review discusses the hormonal treatment of endometriosis in women of reproductive age, citing various studies on progestogens and ovulation inhibitors.

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This 1969 review article by Husslein synthesizes existing literature on the pharmacological management of endometriosis, focusing primarily on hormonal interventions for women of reproductive age. The author evaluates the efficacy of various treatments, including conservative surgical approaches combined with androgen-gestagen combinations, progestogens like medroxyprogesterone acetate, and ovulation inhibitors that induce hypoestrogenic amenorrhea. Key findings highlight the therapeutic potential of creating artificial menopause or suppressing ovulation to alleviate symptoms and reduce lesion size, while noting the importance of long-term follow-up to assess treatment durability. This paper is centrally about endometriosis — specifically reviewing historical drug therapies such as progestins and androgens used to manage the condition prior to the widespread adoption of GnRH agonists.

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Literatur Bayer, R.: Die Behandlung der Endometriose bei Frauen im Fertilitätsalter. Konservative Operation, Androgen-Gestagenkombinationen. Zbl. Gynäk.86, 537–548 (1964). Casper, D. J.: Progestional changes in areas of adenomyosis. Report of 4 cases. Obstet. and Gynec.24, 111–115 (1964). Dapunt, O.: Erfahrungen mit der therapeutischen Amenorrhoe. Zbl. Gynäk.87, 896–903 (1965). Gunning, J. E., andD. Mayer: The effect of medroxyprogesterone acetate on endometriosis in the human female. Fertil. and Steril.18, 759–774 (1967). Kistner, R. W.: The effects of new synthetic progestogens on endometriosis in the human female. Fertil. and Steril.16, 61–80 (1965). —: Current status of the hormonal treatment of endometriosis. Clin. Obstet. Gynec.9, 271–292 (1966). Peeters, F., u.R. Oeyen: Zyklische Behandlung der Endometriose durch Ovulationshemmer. Bibl. gynaec. (Basel)32, 221–228 (1965). Richter, K.: Die konservative Behandlung der Endometriose. Geburtsh. u. Frauenheilk.24, 737–760 (1964). —: Die Bedeutung der mit Lynoestrenol (Orgametril) erzeugten hypoöstrogenen Amenorrhoe für die Therapie der Endometriosis externa. Wien. klin. Wschr.80, 432–435 (1968). Thomassen, H., andH. G. Berthelsen: Treatment of endometriosis with progestogenes. Dan. med. Bull.13, 33–35 (1966). Williams, B. F. P.: Conservative management of endometriosis: Follow-up observations of progestin therapie. Obstet. and Gynec.30, 76–82 (1967). Author information Authors and Affiliations Rights and permissions About this article Cite this article Husslein, H. Die medikamentöse Behandlung der Endometriose. Arch. Gynak. 207, 265–271 (1969). https://doi.org/10.1007/BF00683070 Issue date: DOI: https://doi.org/10.1007/BF00683070

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Lynestrenol Androgens Androgens Endometriosis Endometriosis Estrogens Estrogens Female Humans Lynestrenol Progestins Progestins

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