A retrospective study of risk factors for calf venous thrombosis in patients with cerebral hemorrhage

Abstract Purpose：To investigate the risk factors for calf venous thrombosis in patients with cerebral hemorrhage, so as to provide a reference for customized clinical decision.Methods：396 intracerebral hemorrhage (ICH) patients were enrolled in this retrospective study from January 2017 to December 2019. Risk factors and predictors of occurrence for Muscle calf venous thrombosis (MCVT) were summarized and analyzed by Chi-square test and logistic regression analysis.Results: 128 ICH patients with MCVT and 268 without ones were included. Demographic features comparison showed that ICH with MCVT patients showed older average age than those without ones (p=0.039). Co-morbid diseases analysis showed that patients with MCVT tend to complicate with Diabetes Mellitus (DM) (p=0.040). The comparison of laboratory examinations showed serum level of glucose (p=0.011), Fibrinogen (p=0.046) and D-Dimer (p=0.007) was significantly different. For clinical manifestations, the coma degree (GCS score) and muscle strength level were related to occurring of MCVT. Multivariate logistic regression identified higher age (OR=1.036, 95%CI =1.009-1.064, P= 0.008), higher D-Dimer level (OR=2.379, 95%CI =1.338-4.231, P= 0.003), low GCS (OR=0.932, 95%CI =0.868-0.998, P= 0.044) and lower affected side muscle strength (0-3 grade) (OR=1.624, 95%CI =1.009-2.614, P= 0.046) will predict higher incidence of MCVT in ICH patients.Conclusion: According to our study, higher age, higher D-Dimer level, lower GCS score and lower affected side muscle strength were associated with higher incidence of MCVT in ICH patients. Clinical doctors should pay more attention to prevent MCVT in ICH patients which coincide with those risk factors.