Innovative photothermal therapy strategies for melanoma utilizing MXene photothermal fiber membranes

Innovative photothermal therapy strategies for melanoma utilizing MXene photothermal fiber membranes | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 17 March 2025 V1 Latest version Share on Innovative photothermal therapy strategies for melanoma utilizing MXene photothermal fiber membranes Authors : Lili Dong , Shuting Li , Xinlei Yang , Lin Lv , Jingfei Wang , Xiaozhou Xin , and Fukai Liu 0009-0004-1416-6391 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174223534.41115840/v1 255 views 133 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Photothermal therapy (PTT) employs photoabsorbing nanomaterials to convert near-infrared (NIR) light into localized hyperthermia for targeted tumor ablation. In this study, biocompatible and stable MXene photothermal fiber membranes were synthesized by integrating metal carbide MXene with the biodegradable polymer polylactic acid (PLA) through electrospinning techniques. The photothermal efficiency of these membranes was assessed via NIR laser irradiation experiments. For PTT treatment evaluation, a melanoma model was developed using C57BL/6J mice, into which the innovative MXene photothermal fiber membranes(MXene-PEG/PLA fiber membranes) was implanted. The findings indicated that the MXene-PEG/PLA fiber membranes significantly diminished both the volume and weight of tumors. Furthermore, there was a notable reduction in tumor cell apoptosis and vascular density, alongside a marked improvement in the integrity of the heart, spleen, lungs, and kidneys in the treated mice. These results suggest that the MXene-PEG/PLA fiber membranes represent a safe and effective molecular material for use in photothermal therapy. Supplementary Material File (manuscript.docx) Download 4.42 MB Information & Authors Information Version history V1 Version 1 17 March 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords h&e staining masson staining melanoma mxene photothermal fiber membranes photothermal therapy Authors Affiliations Lili Dong First Affiliated Hospital of Harbin Medical University View all articles by this author Shuting Li First Affiliated Hospital of Harbin Medical University View all articles by this author Xinlei Yang First Affiliated Hospital of Harbin Medical University View all articles by this author Lin Lv First Affiliated Hospital of Harbin Medical University View all articles by this author Jingfei Wang Harbin Institute of Technology View all articles by this author Xiaozhou Xin Harbin Institute of Technology View all articles by this author Fukai Liu 0009-0004-1416-6391 [email protected] First Affiliated Hospital of Harbin Medical University View all articles by this author Metrics & Citations Metrics Article Usage 255 views 133 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Lili Dong, Shuting Li, Xinlei Yang, et al. Innovative photothermal therapy strategies for melanoma utilizing MXene photothermal fiber membranes. Authorea . 17 March 2025. DOI: https://doi.org/10.22541/au.174223534.41115840/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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