Recurrent clear cell carcinoma of the ovary changing into producing parathyroid hormone-related protein (PTH-rP) with hypercalcemia

M Koshiyama, Koshiyama M, H Fujii, Fujii H, Konishi M, M Konishi, Nanno H, H Nanno, M Hayashi, Hayashi M, K Tauchi, Tauchi K, M. Yoshida, Yoshida M
European journal of obstetrics, gynecology, and reproductive biology · 1999 · doi:10.1016/s0301-2115(98)00165-1 · PMID:10206422
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This case study reports a recurrent ovarian clear cell carcinoma that developed parathyroid hormone-related protein (PTH-rP) production, leading to hypercalcemia, unlike the primary tumor which was immunonegative for PTH-rP.

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Abstract

We experienced the case of a clear cell carcinoma of the ovary arising from an endometrial cyst, which started to produce parathyroid hormone-related protein (PTH-rP) in a recurrent tumor, thus inducing hypercalcemia. Using immunohistochemical analysis, we demonstrated that the primary carcinoma was immunonegative for PTH-rP, but that the recurrent carcinoma was strongly immunopositive for PTH-rP.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell Hypercalcemia Ovarian Neoplasms Protein Biosynthesis Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Endometriosis Endometriosis Female Humans Hypercalcemia Immunohistochemistry Middle Aged Neoplasm Recurrence, Local Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Parathyroid Hormone-Related Protein Proteins

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europepmc
last seen: 2026-09-20T09:27:46.357103+00:00
pubmed
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License: public-domain-us · commercial use OK · attribution required
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