Clinical study on treatment of intrauterine insemination for endometriosis complicated with infertility

Objective:To explore the relative factors affecting the clinical pregnancy rate of intrauterine insemination(IUI)for the treatment of infertility caused by endometriosis.Methods:The clinical data of 100 endometriosis patients complicated with infertility undergoing 205 IUI cycles during Jan.2008 to Jan.2014 were analyzed.The influences of endometriosis fertility index(EFI),gonadotropin releasing hormone analogues(GnRH-a)and the different regimen for ovulation on the clinical pregnancy rate of IUI were investigated.Results:The clinical pregnancy rate and the cumulative pregnancy rate were 21.1%and 40.0%in patients with EFI≥9,significantly higher than those of patients with EFI≤8(9.3%and 20.0%,respectively,P0.05);The clinical pregnancy rate was 14.4%in ovarian stimulation cycles and 0in natural cycles;The clinical pregnancy rates of patients receiving and no receiving GnRH-a therapy before IUI were 16.1%and 10.8%,respectively(P0.05);The clinical and twin pregnancy rates of patients with gonadotropin(Gn)ovulation were 15.8%and 13.6%respectively,which was 10.9%and 16.7% with other regimen for ovulation,showing no statistically significant differences(Pall0.05).Conclusions:The patients with EFI≥9should receive IUI therapy after laparoscopic operation as soon as possible,GnRH-a pretreatment before IUI is not recommended,and the combination of ovulation and IUI could increase the pregnancy rate.