Application of Ultrasound-guided Intercostal Nerve Block in Retroperitoneal Laparoscopic Nephrectomy

Application of Ultrasound-guided Intercostal Nerve Block in Retroperitoneal Laparoscopic Nephrectomy | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Application of Ultrasound-guided Intercostal Nerve Block in Retroperitoneal Laparoscopic Nephrectomy Lamei Zheng, Chuang Wei, Rong Lv, Tongxuan Wang This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-1020294/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Purpose: Surgical stimulation causes many pathophysiological changes which are not conducive to the recovery of patients, this trail aims to investigate whether intercostal nerve block can reduce the perioperative stress response and postoperative pain in patients undergoing elective retroperitoneal laparoscopic nephrectomy. Patients and methods: 40 patients were recruited and randomly assigned to Test groupand Blank group. Results: Our study found that the catecholamine and cortisol levels in two groups were higher than the baseline value after pneumoperitoneum, (P＜0.05), while the catecholamine level was lower in Test groupthan in Blank group (P＜0.05), and there is no differences of cortisol levels was observed in two groups. The catecholamines and cortisol levels of two groups were basically restored to the preoperative level after 24 hours surgery, The concentration of IL-6 and IL-10 in two groups increased at 24 hours after surgery, but there was no differences was observed between the two groups at the same point. And the usage of analgesic during operation was less in the Test group than Blank group (P＜0.05). Conclusion : Intercostal nerve block can reduce the stress response of patients undergoing retroperitoneal laparoscopic nephrectomy and reduce the usage of perioperative analgesics. Tial registration statement : This trial has been applied by the ethics Association of Chongqing cancer hospital. Anesthesiology & Pain Medicine stress catecholamine cortisol atelectasis Full Text Additional Declarations No competing interests reported. Supplementary Files CONSORT2010Checklist1.doc Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-1020294","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":63701185,"identity":"efe8d550-b524-4a41-9b08-abe1414cf07e","order_by":0,"name":"Lamei Zheng","email":"","orcid":"","institution":"Affiliated Cancer Hospital of Chongqing University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Lamei","middleName":"","lastName":"Zheng","suffix":""},{"id":63701186,"identity":"ee910b4a-166c-414e-a745-41e9d25f8321","order_by":1,"name":"Chuang 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atelectasis","lastPublishedDoi":"10.21203/rs.3.rs-1020294/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-1020294/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003ePurpose: \u003c/strong\u003eSurgical stimulation causes many pathophysiological changes which are not conducive to the recovery of patients, this trail aims to investigate whether intercostal nerve block can reduce the perioperative stress response and postoperative pain in patients undergoing elective retroperitoneal laparoscopic nephrectomy.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003ePatients and methods:\u003c/strong\u003e40 patients were recruited and randomly assigned to Test groupand Blank group.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults: \u003c/strong\u003eOur study found that the catecholamine and cortisol levels in two groups were higher than the baseline value after pneumoperitoneum, (P＜0.05), while the catecholamine level was lower in Test groupthan in Blank group (P＜0.05), and there is no differences of cortisol levels was observed in two groups. 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And the usage of analgesic during operation was less in the Test group than Blank group (P＜0.05).\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eConclusion : \u003c/strong\u003eIntercostal nerve block can reduce the stress response of patients undergoing retroperitoneal laparoscopic nephrectomy and reduce the usage of perioperative analgesics.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eTial registration statement : \u003c/strong\u003eThis trial has been applied by the ethics Association of Chongqing cancer hospital.\u003c/p\u003e","manuscriptTitle":"Application of Ultrasound-guided Intercostal Nerve Block in Retroperitoneal Laparoscopic Nephrectomy","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2021-11-30 15:20:01","doi":"10.21203/rs.3.rs-1020294/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"c1408800-b1ed-4f3d-a27b-e546285866ce","owner":[],"postedDate":"November 30th, 2021","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":8725093,"name":"Anesthesiology \u0026 Pain Medicine"}],"tags":[],"updatedAt":"2022-03-29T03:29:16+00:00","versionOfRecord":[],"versionCreatedAt":"2021-11-30 15:20:01","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-1020294","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-1020294","identity":"rs-1020294","version":["v1"]},"buildId":"FbvkV6FR0MCFSLy54lSbu","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}